Chlorpropamide


Chlorpropamide
Chlorpropamide
Systematic (IUPAC) name
4-chloro-N-(propylcarbamoyl)benzenesulfonamide
Clinical data
Trade names Diabinese
AHFS/Drugs.com monograph
MedlinePlus a682479
Licence data US FDA:link
Pregnancy cat.  ?
Legal status  ?
Pharmacokinetic data
Half-life 36 hours
Identifiers
CAS number 94-20-2 YesY
ATC code A10BB02
PubChem CID 2727
DrugBank APRD00029
ChemSpider 2626 YesY
UNII WTM2C3IL2X YesY
KEGG D00271 YesY
ChEBI CHEBI:3650 YesY
ChEMBL CHEMBL498 YesY
Chemical data
Formula C10H13ClN2O3S 
Mol. mass 276.74 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Chlorpropamide is a drug in the sulphonylurea class used to treat type 2 diabetes mellitus. It is a long-acting sulphonylurea. It has more side effects than other sulphonylureas and its use is no longer recommended.

Mechanism of action

Like other sulfonylureas, chlorpropamide acts to increase the secretion of insulin, so it is only effective in patients who have some pancreatic beta cell function. It can cause relatively long episodes of hypoglycemia; this is one reason why shorter-acting sulfonylureas such as gliclazide or tolbutamide are used instead. The risk of hypoglycemia makes this drug a poor choice for the elderly and patients with mild to moderate hepatic and renal impairment. Chlorpropamide is also used in Partial Central Diabetes Insipidus.

Cautions and contraindications

Chlorpropamide and other sulphonylureas encourage weight gain, so they are generally not favored for use in very obese patients. Metformin (Glucophage) is considered a better drug for these patients. Sulfonylureas should be avoided in patients with hepatic and renal impairment, patients with porphyria, patients who are breastfeeding, and patients with ketoacidosis. Not indicated for patients more than 65 years of age.

Other side effects

Other side effects of chlorpropamide include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation. It may cause facial flushing after the ingestion of alcohol. It may increase secretion of antidiuretic hormone (ADH), which can lead to hyponatremia. It also markedly raises the serum level of alkaline phosphatase.


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • chlorpropamide — ● chlorpropamide nom masculin Sulfamide doué de propriétés hypoglycémiantes, employé dans le traitement du diabète sucré …   Encyclopédie Universelle

  • chlorpropamide — n. an oral hypoglycaemic drug (see sulphonylurea) used in the treatment of type 2 diabetes and diabetes insipidus. Because it is very long acting, chlorpropamide has more side effects than other sulphonylureas and carries a risk of hypoglycaemia; …   The new mediacal dictionary

  • chlorpropamide — noun Etymology: chlor + propane + amide Date: 1960 a sulfonylurea drug C10H13ClN2O3S used orally to reduce blood sugar in the treatment of mild diabetes …   New Collegiate Dictionary

  • chlorpropamide — /klawr prop euh muyd , proh peuh , klohr /, n. Pharm. an oral hypoglycemic substance, C10H13ClN2O3S, used to augment insulin secretion in the treatment of certain kinds of diabetes mellitus. [1955 60; CHLOR 2 + PROP(ANE) + AMIDE] * * * …   Universalium

  • chlorpropamide — noun A sulfonylurea antidiabetic drug …   Wiktionary

  • chlorpropamide — An orally effective hypoglycemic agent related chemically and pharmacologically to tolbutamide; used in controlling hyperglycemia in selected patients with adult onset (type II) diabetes mellitus. * * * chlor·prop·amide präp ə .mīd, prōp n a… …   Medical dictionary

  • chlorpropamide — chlor·prop·amide …   English syllables

  • chlorpropamide — ˈpräpəˌmīd, prōp , mə̇d noun Etymology: chlor + propane + amide : a sulfonylurea drug C10H13ClN2O3S used to reduce blood sugar in the treatment of mild diabetes * * * /klawr prop euh muyd , proh peuh , klohr /, n. Pharm. an oral hypoglycemic… …   Useful english dictionary

  • Хлорпропамид (Chlorpropamide) — лекарственное вещество, снижающее содержание сахара в крови. Применяется для лечения инсулино независимого диабета у взрослых людей. Назначается внутрь; возможные побочные эффекты: кожные аллергические реакции и расстройства пищеварения. Торговое …   Медицинские термины

  • Sulfonylurée — Chlorpropamide Tolbutamide …   Wikipédia en Français


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.