Name = Aase syndrome
DiseasesDB = 29332
OMIM = 147800
Aase syndrome or Aase-Smith syndrome is a rare
inherited disordercharacterized by anemiawith some joint and skeletal deformities. Aase syndrome is thought to be an autosomal dominant inherited disorder. The genetic basis of the disease is not known. The anemia is caused by underdevelopment of the bone marrow, which is where blood cells
It is named after the American paediatricians
Jon Morton Aaseand David Weyhe Smith.
* Mildly slowed growth
* Pale skin
* Delayed closure of fontanelles (soft spots)
* Narrow shoulders
* Triple jointed thumbs, absent or small knuckles, decreased skin creases at finger joints
* Inability to fully extend the joints from birth (congenital contractures)
* Deformed ears
* Droopy eye lids
igns and tests
* A CBC (
complete blood count) will show anemia and a decrease in the white blood cellcount.
echocardiogrammay reveal heart defects (ventricular septal defect is most common).
* X-rays will show skeletal abnormalities as described above.
* A bone marrow
biopsymay be performed.
blood transfusions are given in the first year of life to treat anemia. Prednisone may be given, although this should be avoided in infancy because of side effects on growth and brain development. A bone marrow transplantmay be necessary if other treatment fails.
Anemia usually resolves over the years.
* Complications related to anemia include weakness, fatigue, and decreased oxygenation of the blood.
* Decreased white blood cells alter the body's ability to fight infection.
* If a heart defect exists, it may cause multiple complications (depending on the specific defect).
* Severe cases have been associated with still birth or early death.
As with most genetic diseases there is no way to prevent the entire disease. With prompt recognition and treatment of infections in childhood, the complications of low white blood cell counts may be limited.
* PMID 5678002
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Look at other dictionaries:
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