CXCR5 also known as Burkitt lymphoma receptor 1 (BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family. The BLR1 gene is specifically expressed in Burkitt's lymphoma and lymphatic tissues, such as follicles in lymph nodes as well as in spleen. The gene plays an essential role in B cell migration.cite journal | author = Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M | title = A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen | journal = Cell | volume = 87 | issue = 6 | pages = 1037–47 | year = 1996 | pmid = 8978608 | doi = 10.1016/S0092-8674(00)81798-5 | issn = ]

CXCR5 has also recently been designated CD185 (cluster of differentiation 185).


Further reading

citations =
*cite journal | author=Lipp M, Müller G |title=Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking. |journal=Verhandlungen der Deutschen Gesellschaft für Pathologie |volume=87 |issue= |pages= 90–101 |year= 2006 |pmid= 16888899 |doi=
*cite journal | author=Dobner T, Wolf I, Emrich T, Lipp M |title=Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma. |journal=Eur. J. Immunol. |volume=22 |issue= 11 |pages= 2795–9 |year= 1992 |pmid= 1425907 |doi=
*cite journal | author=Barella L, Loetscher M, Tobler A, "et al." |title=Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation. |journal=Biochem. J. |volume=309 ( Pt 3) |issue= |pages= 773–9 |year= 1995 |pmid= 7639692 |doi=
*cite journal | author=Legler DF, Loetscher M, Roos RS, "et al." |title=B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. |journal=J. Exp. Med. |volume=187 |issue= 4 |pages= 655–60 |year= 1998 |pmid= 9463416 |doi=
*cite journal | author=Gunn MD, Ngo VN, Ansel KM, "et al." |title=A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. |journal=Nature |volume=391 |issue= 6669 |pages= 799–803 |year= 1998 |pmid= 9486651 |doi= 10.1038/35876
*cite journal | author=Müller G, Lipp M |title=Signal transduction by the chemokine receptor CXCR5: structural requirements for G protein activation analyzed by chimeric CXCR1/CXCR5 molecules. |journal=Biol. Chem. |volume=382 |issue= 9 |pages= 1387–97 |year= 2002 |pmid= 11688722 |doi=
*cite journal | author=Schaerli P, Loetscher P, Moser B |title=Cutting edge: induction of follicular homing precedes effector Th cell development. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6082–6 |year= 2002 |pmid= 11714765 |doi=
*cite journal | author=Kim CH, Johnston B, Butcher EC |title=Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity. |journal=Blood |volume=100 |issue= 1 |pages= 11–6 |year= 2002 |pmid= 12070001 |doi= 10.1182/blood-2001-12-0196
*cite journal | author=Carlsen HS, Baekkevold ES, Johansen FE, "et al." |title=B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue. |journal=Gut |volume=51 |issue= 3 |pages= 364–71 |year= 2002 |pmid= 12171958 |doi=
*cite journal | author=Battle TE, Yen A |title=Ectopic expression of CXCR5/BLR1 accelerates retinoic acid- and vitamin D(3)-induced monocytic differentiation of U937 cells. |journal=Exp. Biol. Med. (Maywood) |volume=227 |issue= 9 |pages= 753–62 |year= 2002 |pmid= 12324654 |doi=
*cite journal | author=Lisignoli G, Toneguzzi S, Piacentini A, "et al." |title=Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release. |journal=J. Cell. Physiol. |volume=194 |issue= 1 |pages= 71–9 |year= 2003 |pmid= 12447991 |doi= 10.1002/jcp.10188
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chan CC, Shen D, Hackett JJ, "et al." |title=Expression of chemokine receptors, CXCR4 and CXCR5, and chemokines, BLC and SDF-1, in the eyes of patients with primary intraocular lymphoma. |journal=Ophthalmology |volume=110 |issue= 2 |pages= 421–6 |year= 2003 |pmid= 12578791 |doi= 10.1016/S0161-6420(02)01737-2
*cite journal | author=Flynn G, Maru S, Loughlin J, "et al." |title=Regulation of chemokine receptor expression in human microglia and astrocytes. |journal=J. Neuroimmunol. |volume=136 |issue= 1-2 |pages= 84–93 |year= 2003 |pmid= 12620646 |doi=
*cite journal | author=Lisignoli G, Piacentini A, Toneguzzi S, "et al." |title=Age-associated changes in functional response to CXCR3 and CXCR5 chemokine receptors in human osteoblasts. |journal=Biogerontology |volume=4 |issue= 5 |pages= 309–17 |year= 2004 |pmid= 14618028 |doi=
*cite journal | author=Aust G, Sittig D, Becherer L, "et al." |title=The role of CXCR5 and its ligand CXCL13 in the compartmentalization of lymphocytes in thyroids affected by autoimmune thyroid diseases. |journal=Eur. J. Endocrinol. |volume=150 |issue= 2 |pages= 225–34 |year= 2004 |pmid= 14763921 |doi=
*cite journal | author=Qiuping Z, Jie X, Youxin J, "et al." |title=Selectively frequent expression of CXCR5 enhances resistance to apoptosis in CD8(+)CD34(+) T cells from patients with T-cell-lineage acute lymphocytic leukemia. |journal=Oncogene |volume=24 |issue= 4 |pages= 573–84 |year= 2005 |pmid= 15580304 |doi= 10.1038/sj.onc.1208184
*cite journal | author=Howard OM, Dong HF, Su SB, "et al." |title=Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate. |journal=Blood |volume=105 |issue= 11 |pages= 4207–14 |year= 2005 |pmid= 15713799 |doi= 10.1182/blood-2004-07-2697
*cite journal | author=Steinmetz OM, Panzer U, Kneissler U, "et al." |title=BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection. |journal=Kidney Int. |volume=67 |issue= 4 |pages= 1616–21 |year= 2005 |pmid= 15780119 |doi= 10.1111/j.1523-1755.2005.00244.x
*cite journal | author=Hu C, Xiong J, Zhang L, "et al." |title=PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19+CD34+ B cells from patients with B cell lineage acute and chronic lymphocytic leukemia. |journal=Cell. Mol. Immunol. |volume=1 |issue= 4 |pages= 280–94 |year= 2006 |pmid= 16225771 |doi=

G protein-coupled receptors

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