Cyclin-dependent kinase 6

Cyclin-dependent kinase 6

PDB rendering based on 1bi7.
Symbols CDK6; MGC59692; PLSTIRE
External IDs OMIM603368 MGI1277162 HomoloGene963 GeneCards: CDK6 Gene
EC number
RNA expression pattern
PBB GE CDK6 207143 at tn.png
More reference expression data
Species Human Mouse
Entrez 1021 12571
Ensembl ENSG00000105810 ENSMUSG00000040274
UniProt Q00534 n/a
RefSeq (mRNA) NM_001145306.1 NM_009873.2
RefSeq (protein) NP_001138778.1 NP_034003.1
Location (UCSC) Chr 7:
92.23 – 92.47 Mb
Chr 5:
3.34 – 3.52 Mb
PubMed search [1] [2]

Cell division protein kinase 6 is an enzyme that in humans is encoded by the CDK6 gene.[1][2]

It is regulated by Cyclin D.

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.[2]



Cyclin-dependent kinase 6 has been shown to interact with CDKN2C,[3][4][5] P16,[6][7][8] PPM1B,[9] Cyclin D3,[10][11] Cyclin D1[12][10] and PPP2CA.[9]


  1. ^ Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (Aug 1992). "A family of human cdc2-related protein kinases". EMBO J 11 (8): 2909–17. PMC 556772. PMID 1639063. 
  2. ^ a b "Entrez Gene: CDK6 cyclin-dependent kinase 6". 
  3. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  4. ^ Guan, K L; Jenkins C W, Li Y, Nichols M A, Wu X, O'Keefe C L, Matera A G, Xiong Y (Dec. 1994). "Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function". Genes Dev. (UNITED STATES) 8 (24): 2939–52. doi:10.1101/gad.8.24.2939. ISSN 0890-9369. PMID 8001816. 
  5. ^ Jeffrey, P D; Tong L, Pavletich N P (Dec. 2000). "Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors". Genes Dev. (UNITED STATES) 14 (24): 3115–25. doi:10.1101/gad.851100. ISSN 0890-9369. PMC 317144. PMID 11124804. 
  6. ^ Fåhraeus, R; Paramio J M, Ball K L, Laín S, Lane D P (Jan. 1996). "Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A". Curr. Biol. (ENGLAND) 6 (1): 84–91. doi:10.1016/S0960-9822(02)00425-6. ISSN 0960-9822. PMID 8805225. 
  7. ^ Russo, A A; Tong L, Lee J O, Jeffrey P D, Pavletich N P (Sep. 1998). "Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a". Nature (ENGLAND) 395 (6699): 237–43. doi:10.1038/26155. ISSN 0028-0836. PMID 9751050. 
  8. ^ Kaldis, P; Ojala P M, Tong L, Mäkelä T P, Solomon M J (Dec. 2001). "CAK-independent activation of CDK6 by a viral cyclin". Mol. Biol. Cell (United States) 12 (12): 3987–99. ISSN 1059-1524. PMC 60770. PMID 11739795. 
  9. ^ a b Cheng, A; Kaldis P, Solomon M J (Nov. 2000). "Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms". J. Biol. Chem. (UNITED STATES) 275 (44): 34744–9. doi:10.1074/jbc.M006210200. ISSN 0021-9258. PMID 10934208. 
  10. ^ a b Lin, J; Jinno S, Okayama H (Apr. 2001). "Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence". Oncogene (England) 20 (16): 2000–9. doi:10.1038/sj.onc.1204375. ISSN 0950-9232. PMID 11360184. 
  11. ^ Meyerson, M; Harlow E (Mar. 1994). "Identification of G1 kinase activity for cdk6, a novel cyclin D partner". Mol. Cell. Biol. (UNITED STATES) 14 (3): 2077–86. ISSN 0270-7306. PMC 358568. PMID 8114739. 
  12. ^ Sugimoto, M; Nakamura T, Ohtani N, Hampson L, Hampson I N, Shimamoto A, Furuichi Y, Okumura K, Niwa S, Taya Y, Hara E (Nov. 1999). "Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)". Genes Dev. (UNITED STATES) 13 (22): 3027–33. doi:10.1101/gad.13.22.3027. ISSN 0890-9369. PMC 317153. PMID 10580009. 

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