Only one member belongs to the CX3C sub-family of chemokine receptors - CX3CR1. As the name suggests, this receptor binds the chemokine CX3CL1 (also called neurotactin or fractalkine).

Expression of this receptor appears to be associated with lymphocytes. [Imai et al. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91: 521-530, 1997. ]


Further reading

citations =
*cite journal | author=Robertson MJ |title=Role of chemokines in the biology of natural killer cells. |journal=J. Leukoc. Biol. |volume=71 |issue= 2 |pages= 173–83 |year= 2002 |pmid= 11818437 |doi=
*cite journal | author=Raport CJ, Schweickart VL, Eddy RL, "et al." |title=The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues. |journal=Gene |volume=163 |issue= 2 |pages= 295–9 |year= 1995 |pmid= 7590284 |doi=
*cite journal | author=Combadiere C, Ahuja SK, Murphy PM |title=Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene. |journal=DNA Cell Biol. |volume=14 |issue= 8 |pages= 673–80 |year= 1995 |pmid= 7646814 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Imai T, Hieshima K, Haskell C, "et al." |title=Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. |journal=Cell |volume=91 |issue= 4 |pages= 521–30 |year= 1997 |pmid= 9390561 |doi=
*cite journal | author=Combadiere C, Salzwedel K, Smith ED, "et al." |title=Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1. |journal=J. Biol. Chem. |volume=273 |issue= 37 |pages= 23799–804 |year= 1998 |pmid= 9726990 |doi=
*cite journal | author=Mizoue LS, Bazan JF, Johnson EC, Handel TM |title=Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1. |journal=Biochemistry |volume=38 |issue= 5 |pages= 1402–14 |year= 1999 |pmid= 9931005 |doi= 10.1021/bi9820614
*cite journal | author=Maho A, Bensimon A, Vassart G, Parmentier M |title=Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 265–8 |year= 2000 |pmid= 10702689 |doi=
*cite journal | author=Faure S, Meyer L, Costagliola D, "et al." |title=Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1. |journal=Science |volume=287 |issue= 5461 |pages= 2274–7 |year= 2000 |pmid= 10731151 |doi=
*cite journal | author=Yoneda O, Imai T, Goda S, "et al." |title=Fractalkine-mediated endothelial cell injury by NK cells. |journal=J. Immunol. |volume=164 |issue= 8 |pages= 4055–62 |year= 2000 |pmid= 10754298 |doi=
*cite journal | author=Meucci O, Fatatis A, Simen AA, Miller RJ |title=Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 8075–80 |year= 2000 |pmid= 10869418 |doi= 10.1073/pnas.090017497
*cite journal | author=Papadopoulos EJ, Fitzhugh DJ, Tkaczyk C, "et al." |title=Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane-bound chemokine expressed constitutively in diverse cells of the skin. |journal=Eur. J. Immunol. |volume=30 |issue= 8 |pages= 2355–61 |year= 2000 |pmid= 10940926 |doi=
*cite journal | author=Moatti D, Faure S, Fumeron F, "et al." |title=Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease. |journal=Blood |volume=97 |issue= 7 |pages= 1925–8 |year= 2001 |pmid= 11264153 |doi=
*cite journal | author=Foussat A, Bouchet-Delbos L, Berrebi D, "et al." |title=Deregulation of the expression of the fractalkine/fractalkine receptor complex in HIV-1-infected patients. |journal=Blood |volume=98 |issue= 6 |pages= 1678–86 |year= 2001 |pmid= 11535497 |doi=
*cite journal | author=Dichmann S, Herouy Y, Purlis D, "et al." |title=Fractalkine induces chemotaxis and actin polymerization in human dendritic cells. |journal=Inflamm. Res. |volume=50 |issue= 11 |pages= 529–33 |year= 2002 |pmid= 11766992 |doi=
*cite journal | author=Brand S, Sakaguchi T, Gu X, "et al." |title=Fractalkine-mediated signals regulate cell-survival and immune-modulatory responses in intestinal epithelial cells. |journal=Gastroenterology |volume=122 |issue= 1 |pages= 166–77 |year= 2002 |pmid= 11781291 |doi=
*cite journal | author=Utaipat U, Duerr A, Rudolph DL, "et al." |title=Coreceptor utilization of HIV type 1 subtype E viral isolates from Thai men with HIV type 1-infected and uninfected wives. |journal=AIDS Res. Hum. Retroviruses |volume=18 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11804551 |doi= 10.1089/088922202753394664
*cite journal | author=Fong AM, Alam SM, Imai T, "et al." |title=CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesion. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19418–23 |year= 2002 |pmid= 11909868 |doi= 10.1074/jbc.M201396200

External links


update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • CX3CL1 — Chemokine (C X3 C motif) ligand 1 PDB rendering based on 1b2t …   Wikipedia

  • Microglia — Code TH H2. Microglia are a type of glial cell that are the resident macrophages of the brain and spinal cord, and thus act as the first and main form of active immune defense in the central nervous system (CNS). Microglia constitute …   Wikipedia

  • Chemokine — Small cytokines (intecrine/chemokine), interleukin 8 like Solution structure of interleukin 8, a chemokine of the CXC subfamily Identifiers Symbol IL8 …   Wikipedia

  • Chemokine receptor — Typical structure of a chemokine receptor, with seven transmembrane domains and a characteristic DRY motif in the second intracellular domain. Chemokine receptors are usually linked to a G protein through which they signal. Chemokine receptors… …   Wikipedia

  • Interleukin 8 receptor, beta — Chemokine (C X C motif) receptor 2 Identifiers Symbols CXCR2; CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB External IDs …   Wikipedia

  • Interleukin 8 receptor, alpha — Chemokine (C X C motif) receptor 1 Rendering of 1ILP …   Wikipedia

  • CX3CL1 — Saltar a navegación, búsqueda quimioquina (C X3 C motif) ligando 1 Identificadores Símbolo CX3CL1 Símbolos alt. SCYD1, NTN, C3Xkine, ABCD 3, CXC3C, CXC3, fractalquina, neurotactina Entrez …   Wikipedia Español

  • Grégoire Lauvau — Grégoire Lauvau, né en 1970, est un chercheur à l Institut de pharmacologie Moléculaire et Cellulaire de l INSERM. En tant que Directeur de recherche, il s est spécialisé en immunologie[1]. Sommaire 1 Carrière 2 Annexes …   Wikipédia en Français

  • Osteoprotegerin — Tumor necrosis factor receptor superfamily, member 11b Identifiers Symbols TNFRSF11B; MGC29565; OCIF; OPG; TR1 External IDs …   Wikipedia

  • CCR5 — Chemokine (C C motif) receptor 5 Rendering based on PDB 1ND8 …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.