Annexin A1

Annexin A1

Annexin A1 (or Lipocortin I) is a human protein encoded by the ANXA1 gene. PBB_Summary
section_title =
summary_text = Annexin I belongs to a family of Ca(2+)-dependent phospholipid-binding proteins that have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins, and leukotrienes, annexin I may have potential anti-inflammatory activity. [cite web | title = Entrez Gene: ANXA1 annexin A1| url =| accessdate = ]
The gene for annexin A1 (ANXA1) is upregulated in hairy cell leukemia.

ANXA1 protein expression is specific to hairy cell leukemia.

Detection of ANXA1 (by immunocytochemical means) reportedly provides a simple, highly-sensitive and specific assay for the diagnosis of hairy cell leukemia.

Glucocorticoid stimulate production of lipocortin.

ee also



Further reading

citations =
*cite journal | author=Crompton MR, Moss SE, Crumpton MJ |title=Diversity in the lipocortin/calpactin family. |journal=Cell |volume=55 |issue= 1 |pages= 1–3 |year= 1988 |pmid= 2971450 |doi=
*cite journal | author=Lim LH, Pervaiz S |title=Annexin 1: the new face of an old molecule. |journal=FASEB J. |volume=21 |issue= 4 |pages= 968–75 |year= 2007 |pmid= 17215481 |doi= 10.1096/fj.06-7464rev
*cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=
*cite journal | author=Ando Y, Imamura S, Owada MK, Kannagi R |title=Calcium-induced intracellular cross-linking of lipocortin I by tissue transglutaminase in A431 cells. Augmentation by membrane phospholipids. |journal=J. Biol. Chem. |volume=266 |issue= 2 |pages= 1101–8 |year= 1991 |pmid= 1670773 |doi=
*cite journal | author=Kovacic RT, Tizard R, Cate RL, "et al." |title=Correlation of gene and protein structure of rat and human lipocortin I. |journal=Biochemistry |volume=30 |issue= 37 |pages= 9015–21 |year= 1991 |pmid= 1832554 |doi=
*cite journal | author=Varticovski L, Chahwala SB, Whitman M, "et al." |title=Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C. |journal=Biochemistry |volume=27 |issue= 10 |pages= 3682–90 |year= 1988 |pmid= 2457390 |doi=
*cite journal | author=Pepinsky RB, Sinclair LK, Chow EP, O'Brine-Greco B |title=A dimeric form of lipocortin-1 in human placenta. |journal=Biochem. J. |volume=263 |issue= 1 |pages= 97–103 |year= 1990 |pmid= 2532504 |doi=
*cite journal | author=Wallner BP, Mattaliano RJ, Hession C, "et al." |title=Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. |journal=Nature |volume=320 |issue= 6057 |pages= 77–81 |year= 1986 |pmid= 2936963 |doi= 10.1038/320077a0
*cite journal | author=Kaplan R, Jaye M, Burgess WH, "et al." |title=Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein. |journal=J. Biol. Chem. |volume=263 |issue= 17 |pages= 8037–43 |year= 1988 |pmid= 2967291 |doi=
*cite journal | author=Huebner K, Cannizzaro LA, Frey AZ, "et al." |title=Chromosomal localization of the human genes for lipocortin I and lipocortin II. |journal=Oncogene Res. |volume=2 |issue= 4 |pages= 299–310 |year= 1988 |pmid= 2969496 |doi=
*cite journal | author=Biemann K, Scoble HA |title=Characterization by tandem mass spectrometry of structural modifications in proteins. |journal=Science |volume=237 |issue= 4818 |pages= 992–8 |year= 1987 |pmid= 3303336 |doi=
*cite journal | author=Arcone R, Arpaia G, Ruoppolo M, "et al." |title=Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli. |journal=Eur. J. Biochem. |volume=211 |issue= 1-2 |pages= 347–55 |year= 1993 |pmid= 8425544 |doi=
*cite journal | author=Weng X, Luecke H, Song IS, "et al." |title=Crystal structure of human annexin I at 2.5 A resolution. |journal=Protein Sci. |volume=2 |issue= 3 |pages= 448–58 |year= 1993 |pmid= 8453382 |doi=
*cite journal | author=Mailliard WS, Haigler HT, Schlaepfer DD |title=Calcium-dependent binding of S100C to the N-terminal domain of annexin I. |journal=J. Biol. Chem. |volume=271 |issue= 2 |pages= 719–25 |year= 1996 |pmid= 8557678 |doi=
*cite journal | author=Morgan RO, Fernández MP |title=A BC200-derived element and Z-DNA as structural markers in annexin I genes: relevance to Alu evolution and annexin tetrad formation. |journal=J. Mol. Evol. |volume=41 |issue= 6 |pages= 979–85 |year= 1996 |pmid= 8587144 |doi=
*cite journal | author=Almawi WY, Saouda MS, Stevens AC, "et al." |title=Partial mediation of glucocorticoid antiproliferative effects by lipocortins. |journal=J. Immunol. |volume=157 |issue= 12 |pages= 5231–9 |year= 1997 |pmid= 8955167 |doi=
*cite journal | author=Croxtall JD, Wu HL, Yang HY, "et al." |title=Lipocortin 1 co-associates with cytokeratins 8 and 18 in A549 cells via the N-terminal domain. |journal=Biochim. Biophys. Acta |volume=1401 |issue= 1 |pages= 39–51 |year= 1998 |pmid= 9459484 |doi=
*cite journal | author=Gao J, Li Y, Yan H |title=NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit. |journal=J. Biol. Chem. |volume=274 |issue= 5 |pages= 2971–7 |year= 1999 |pmid= 9915835 |doi=
*cite journal | author=Manda R, Kohno T, Matsuno Y, "et al." |title=Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. |journal=Genomics |volume=61 |issue= 1 |pages= 5–14 |year= 1999 |pmid= 10512675 |doi= 10.1006/geno.1999.5939

External links


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