Eticyclidine

Drugbox
IUPAC_name = N-ethyl-1-phenylcyclohexylamine


width= 120
CAS_number= 2201-15-2
ATC_prefix=
ATC_suffix=
PubChem= 16622
DrugBank=
C=14 | H=21 | N=1
molecular_weight = 203.323 g/mol
bioavailability=
metabolism =
elimination_half-life=
excretion =
pregnancy_category =
legal_status = Schedule I / Class A
routes_of_administration=

Eticyclidine (PCE) is a dissociative anesthetic drug with hallucinogenic effects. It is similar in effects to phencyclidine but is slightly more potent. PCE was developed by Parke-Davis in the 1970s and evaluated for anesthetic potential under the code name CI-400, but research into PCE was not continued after the development of ketamine, a similar drug with more favourable properties. [ Kalir A, Edery H, Pelah Z, Balderman D, Porath G. 1-Phenylcycloalkylamine derivatives. II. Synthesis and pharmacological activity. Journal of Medicinal Chemistry. 1969. 12(3):473-477 ] PCE is slightly more potent than PCP and has similar effects, but its unpleasant taste and tendency to cause nausea made it less accepted by users. [ [http://www.erowid.org/archive/rhodium/chemistry/pcp/sar.html Structure Activity of PCP analogs ] ] Due to its similarity in effects to PCP, PCE was placed into the Schedule 1 list of illegal drugs in the 1970s, although it was only briefly abused in the 1970s and 1980s and is now little known.

ee also

*Phencyclidine
*Ketamine
*Tiletamine
*Rolicyclidine
*Tenocyclidine

References


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