Low grade squamous intraepithelial lesion

Low grade squamous intraepithelial lesion or LSIL or LGSIL is the medical term for a Pap test result indicating possible cervical dysplasia. LSIL usually indicates mild dysplasia (CIN 1), more than likely caused by a human papillomavirus infection.

CIN 1 is the most common and most benign form of cervical intraepithelial neoplasia and usually resolves spontaneously in two years. Because of this, LSIL results can be managed with a simple "watch and wait" philosophy. However, because there is a 12-16% chance of progression to more severe dysplasia, the physician may want to follow the results more aggressively by performing a colposcopy with biopsy. [Wright TC Jr; Massad LS; Dunton CJ; Spitzer M; Wilkinson EJ; Solomon D. "2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests." Am J Obstet Gynecol. 2007 Oct;197(4):346-55.] If the dysplasia progresses, treatment may be necessary. Treatment involves removal of the affected tissue, which can be accomplished by LEEP, cryosurgery, cone biopsy, or laser ablation.

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