Granulocyte colony-stimulating factor receptor

The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114), is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF).cite web | title = Entrez Gene: CSF3R colony stimulating factor 3 receptor (granulocyte)| url =| accessdate = ] The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.

The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction.

Th G-CSF receptors belongs to a family of cytokine receptors known as the "hematopoietin receptor family". Mutations in the intracellular part of this receptor are associated with certain types of leukemia.

GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2.


The class IV isoform defective for both internalization and differentiation signaling.


ee also

* Cluster of differentiation

Further reading

citations =
*cite journal | author=Tsuji K, Ebihara Y |title=Expression of G-CSF receptor on myeloid progenitors. |journal=Leuk. Lymphoma |volume=42 |issue= 6 |pages= 1351–7 |year= 2002 |pmid= 11911419 |doi=
*cite journal | author=Kimura A, Sultana TA |title=Granulocyte colony-stimulating factor receptors on CD34++ cells in patients with myelodysplastic syndrome (MDS) and MDS-acute myeloid leukemia. |journal=Leuk. Lymphoma |volume=45 |issue= 10 |pages= 1995–2000 |year= 2005 |pmid= 15370243 |doi= 10.1080/10428190410001714034
*cite journal | author=Tweardy DJ, Anderson K, Cannizzaro LA, "et al." |title=Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34. |journal=Blood |volume=79 |issue= 5 |pages= 1148–54 |year= 1992 |pmid= 1371413 |doi=
*cite journal | author=Seto Y, Fukunaga R, Nagata S |title=Chromosomal gene organization of the human granulocyte colony-stimulating factor receptor. |journal=J. Immunol. |volume=148 |issue= 1 |pages= 259–66 |year= 1992 |pmid= 1530796 |doi=
*cite journal | author=Fukunaga R, Seto Y, Mizushima S, Nagata S |title=Three different mRNAs encoding human granulocyte colony-stimulating factor receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 8702–6 |year= 1991 |pmid= 1701053 |doi=
*cite journal | author=Fukunaga R, Ishizaka-Ikeda E, Pan CX, "et al." |title=Functional domains of the granulocyte colony-stimulating factor receptor. |journal=EMBO J. |volume=10 |issue= 10 |pages= 2855–65 |year= 1991 |pmid= 1717255 |doi=
*cite journal | author=Inazawa J, Fukunaga R, Seto Y, "et al." |title=Assignment of the human granulocyte colony-stimulating factor receptor gene (CSF3R) to chromosome 1 at region p35-p34.3. |journal=Genomics |volume=10 |issue= 4 |pages= 1075–8 |year= 1991 |pmid= 1833306 |doi=
*cite journal | author=Larsen A, Davis T, Curtis BM, "et al." |title=Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains. |journal=J. Exp. Med. |volume=172 |issue= 6 |pages= 1559–70 |year= 1991 |pmid= 2147944 |doi=
*cite journal | author=Uzumaki H, Okabe T, Sasaki N, "et al." |title=Identification and characterization of receptors for granulocyte colony-stimulating factor on human placenta and trophoblastic cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 23 |pages= 9323–6 |year= 1990 |pmid= 2480598 |doi=
*cite journal | author=Nicholson SE, Oates AC, Harpur AG, "et al." |title=Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 2985–8 |year= 1994 |pmid= 7512720 |doi=
*cite journal | author=Dong F, Hoefsloot LH, Schelen AM, "et al." |title=Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 10 |pages= 4480–4 |year= 1994 |pmid= 7514305 |doi=
*cite journal | author=Dong F, Brynes RK, Tidow N, "et al." |title=Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. |journal=N. Engl. J. Med. |volume=333 |issue= 8 |pages= 487–93 |year= 1995 |pmid= 7542747 |doi=
*cite journal | author=Shimoda K, Okamura S, Harada N, "et al." |title=Identification of a functional receptor for granulocyte colony-stimulating factor on platelets. |journal=J. Clin. Invest. |volume=91 |issue= 4 |pages= 1310–3 |year= 1993 |pmid= 7682568 |doi=
*cite journal | author=Zhao Y, Wagner F, Frank SJ, Kraft AS |title=The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain. |journal=J. Biol. Chem. |volume=270 |issue= 23 |pages= 13814–8 |year= 1995 |pmid= 7775438 |doi=
*cite journal | author=Corey SJ, Burkhardt AL, Bolen JB, "et al." |title=Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 11 |pages= 4683–7 |year= 1994 |pmid= 8197119 |doi=
*cite journal | author=Haniu M, Horan T, Arakawa T, "et al." |title=Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region. |journal=Arch. Biochem. Biophys. |volume=324 |issue= 2 |pages= 344–56 |year= 1996 |pmid= 8554326 |doi= 10.1006/abbi.1995.0047
*cite journal | author=Horan T, Wen J, Narhi L, "et al." |title=Dimerization of the extracellular domain of granuloycte-colony stimulating factor receptor by ligand binding: a monovalent ligand induces 2:2 complexes. |journal=Biochemistry |volume=35 |issue= 15 |pages= 4886–96 |year= 1996 |pmid= 8664280 |doi= 10.1021/bi9525841
*cite journal | author=McCracken S, Layton JE, Shorter SC, "et al." |title=Expression of granulocyte-colony stimulating factor and its receptor is regulated during the development of the human placenta. |journal=J. Endocrinol. |volume=149 |issue= 2 |pages= 249–58 |year= 1996 |pmid= 8708536 |doi=
*cite journal | author=Haniu M, Horan T, Arakawa T, "et al." |title=Disulfide structure and N-glycosylation sites of an extracellular domain of granulocyte-colony stimulating factor receptor. |journal=Biochemistry |volume=35 |issue= 40 |pages= 13040–6 |year= 1996 |pmid= 8855939 |doi= 10.1021/bi960213u
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=

External links


update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Granulocyte colony-stimulating factor — Not to be confused with granulocyte macrophage colony stimulating factor. Colony stimulating factor 3 (granulocyte) Crystal structure of 3 molecules of human G CSF. From PDB …   Wikipedia

  • Granulocyte macrophage colony-stimulating factor receptor — The granulocyte macrophage colony stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte macrophage colony stimulating factor, which stimulates the production of white blood cells. The… …   Wikipedia

  • Colony-stimulating factor — Colony stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate… …   Wikipedia

  • Granulocyte macrophage colony-stimulating factor — Not to be confused with granulocyte colony stimulating factor. Colony stimulating factor 2 (granulocyte macrophage) PDB rendering based on 2gmf …   Wikipedia

  • granulocyte-macrophage colony-stimulating factor — n a colony stimulating factor produced by T cells, macrophages, endothelial cells, and fibroblasts that promotes the differentiation of bone marrow stem cells, stimulates the maturation of precursor cells into granulocytes and macrophages, and… …   Medical dictionary

  • Macrophage colony-stimulating factor — Colony stimulating factor 1 (macrophage) PDB rendering based on 1hmc …   Wikipedia

  • Factor de crecimiento — Saltar a navegación, búsqueda Los factores de crecimiento o GF (degrowth factor) son un conjunto de sustancias, la mayoría de naturaleza proteica que junto con las hormonas y los neurotransmisores desempeñan una importante función en la… …   Wikipedia Español

  • Fibroblast growth factor — Fibroblast growth factors, or FGFs, are a family of growth factors involved in angiogenesis, wound healing, and embryonic development. The FGFs are heparin binding proteins and interactions with cell surface associated heparan sulfate… …   Wikipedia

  • Growth factor — The term growth factor refers to a naturally occurring protein capable of stimulating cellular growth, [DorlandsDict|three/000038554|growth factor] proliferation and cellular differentiation. Growth factors are important for regulating a variety… …   Wikipedia

  • Type I cytokine receptor — Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α helical strands. These receptors are also known under the name hemopoietin receptors, and share a common… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.