TGF beta 3

protein
name=transforming growth factor, beta 3
caption=


width=
HGNCid=11769
Symbol=TGFB3
AltSymbols=
EntrezGene=7043
OMIM=190230
RefSeq=NM_003239
UniProt=
PDB=
ECnumber=
Chromosome=14
Arm=q
Band=24
LocusSupplementaryData=

Transforming growth factor-beta 3 (TGF-β3) is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and development. It belongs to a large family of cytokines called the Transforming growth factor beta superfamily, which includes the TGF-β family, Bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), inhibins and activins.cite journal |author=Herpin A, Lelong C, Favrel P |title=Transforming growth factor-beta-related proteins: an ancestral and widespread superfamily of cytokines in metazoans |journal=Dev Comp Immunol |volume=28 |issue=5 |pages=461–85 |year=2004 |pmid=15062644 |doi=10.1016/j.dci.2003.09.007]

TGF-β3 is believed to regulate molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate. [cite journal |author=Taya Y, O'Kane S, Ferguson M |title=Pathogenesis of cleft palate in TGF-beta3 knockout mice |journal=Development |volume=126 |issue=17 |pages=3869–79 |year=1999 |pmid=10433915] [cite journal |author=Dudas M, Nagy A, Laping N, Moustakas A, Kaartinen V |title=Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway |journal=Dev Biol |volume=266 |issue=1 |pages=96–108 |year=2004 |pmid=14729481 |doi=10.1016/j.ydbio.2003.10.007] This is caused by failure of epithelial cells in both sides of the developing palate to fuse. TGF-β3 also plays an essential role in controlling the development of lungs in mammals, by also regulating cell adhesion and ECM formation in this tissue, [cite journal |author=Kaartinen V, Voncken J, Shuler C, Warburton D, Bu D, Heisterkamp N, Groffen J |title=Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction |journal=Nat Genet |volume=11 |issue=4 |pages=415–21 |year=1995 |pmid=7493022 |doi=10.1038/ng1295-415] and controls wound healing by regulating the movements of epidermal and dermal cells in injured skin. [cite journal |author=Bandyopadhyay B, Fan J, Guan S, Li Y, Chen M, Woodley DT, Li W |title=A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing|journal=J Cell Biol. |volume=172 |issue=7 |pages=1093–105 |year=2006 |pmid=16549496 |doi=10.1083/jcb.200507111]

References


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • TGF-beta 1 — Factor de crecimiento transformante beta 1 Estructura tridimensional de la proteína TGF β1. HUGO …   Wikipedia Español

  • TGF beta — Transforming growth factor beta (TGF β) controls proliferation, cellular differentiation, and other functions in most cells. It plays a role in immunity, cancer, heart disease and Marfan syndrome.Some cells secrete TGF β, and also have receptors… …   Wikipedia

  • TGF beta 1 — protein name=transforming growth factor, beta 1 caption= width= HGNCid=11766 Symbol=TGFB1 AltSymbols=TGFB, DPD1 EntrezGene=7040 OMIM=190180 RefSeq= UniProt= PDB= ECnumber= Chromosome=19 Arm=q Band=13.1 LocusSupplementaryData=Transforming growth… …   Wikipedia

  • TGF beta 2 — Transforming growth factor beta 2 (TGF β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development (alternative names: Glioblastoma derived T cell suppressor factor, G TSF …   Wikipedia

  • TGF-Beta — Der Transforming Growth Factor (Abk. TGF, deut. Transformierender Wachstumsfaktor) gehört zu den Zytokinen zählenden Signalmolekülen. Sie sind namensgebend für die TGF Signalwege. TGF spielen eine sehr wichtige Rolle bei der embryonalen… …   Deutsch Wikipedia

  • TGF beta receptor 2 — Transforming growth factor, beta receptor II (70/80kDa) PDB rendering based on 1ktz …   Wikipedia

  • TGF beta signaling pathway — The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other… …   Wikipedia

  • TGF beta receptors — protein Name=transforming growth factor beta, receptor type I (activin A receptor type II like kinase, 53kDa) caption= width= HGNCid=11772 Symbol=TGFBR1 AltSymbols= EntrezGene=7046 OMIM=190181 RefSeq=NM 004612 UniProt=P36897 PDB= ECnumber=… …   Wikipedia

  • TGF beta receptor 1 — Transforming growth factor, beta receptor I (activin A receptor type II like kinase, 53kDa) is a TGF beta receptor. TGFBR1 is its human gene. PBB Summary section title = summary text = The protein encoded by this gene forms a heteromeric complex… …   Wikipedia

  • Трансформирующий ростовой фактор бета (TGF-beta) — В этой статье не хватает ссылок на источники информации. Информация должна быть проверяема, иначе она может быть поставлена под сомнение и удалена. Вы можете …   Википедия

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.