TGF beta receptors
Name=transforming growth factor beta, receptor type I (activin A receptor type II-like kinase, 53kDa)
Name=transforming growth factor beta, receptor type II (70/80kDa)
Name=transforming growth factor beta, receptor type III
TGFβ receptors are single pass
serine/threonine kinasereceptors. They exist in several different isoforms that can be homo- or heterodimeric. [Heteromeric and homomeric transforming growth factor-beta receptors show distinct signaling and endocytic responses in epithelial cells. "J Biol Chem. 1998 Nov 27; 273(48): 31770-7; PMID|9822641" [http://www.jbc.org/cgi/content/full/273/48/31770 Free text] ] The number of characterized ligands in the TGFβ superfamily far exceeds the number of known receptors, suggesting the promiscuity that exists between the ligandand receptor interactions.
TGF can be found in many different tissue types, including brain,
heart, kidney, liverand testes. Over-expression of TGF can induce renal fibrosis, causing kidney disease, as well as diabetes, and ultimately end-stage renal disease(ESRD). Recent developments have found that, using certain types of protein antagonists against TGFβ receptors, can halt and in some cases reverse the effects of renal fibrosis.
Three TGF-β receptor types can be distinguished by their structural and functional properties. Receptor types I and II have similar ligand binding affinities and can only be distinguished from each other by
peptide mapping, both receptor types I and II have a high affinity for TGF-β1 and low affinity for TGF-β2. TGF-β receptor type III has a high affinity for both TGF-β1 and -β2 and in addition TGF-β1.2. [cite journal | author = Cheifetz S, Andres JL and Massague J. | title = The transforming growth factor-beta receptor type III is a membrane proteoglycan. | journal = J. Biol. Chem. | year= 1988 | volume=263 | issue=32 | pages=16984–16991 | pmid = 2903157]
TGF beta receptor 1
TGF beta receptor 2
* "TGF beta receptor 3"
Wikimedia Foundation. 2010.
Look at other dictionaries:
TGF beta receptor 2 — Transforming growth factor, beta receptor II (70/80kDa) PDB rendering based on 1ktz … Wikipedia
TGF-beta 1 — Factor de crecimiento transformante beta 1 Estructura tridimensional de la proteína TGF β1. HUGO … Wikipedia Español
TGF beta receptor 1 — Transforming growth factor, beta receptor I (activin A receptor type II like kinase, 53kDa) is a TGF beta receptor. TGFBR1 is its human gene. PBB Summary section title = summary text = The protein encoded by this gene forms a heteromeric complex… … Wikipedia
TGF beta signaling pathway — The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other… … Wikipedia
TGF beta — Transforming growth factor beta (TGF β) controls proliferation, cellular differentiation, and other functions in most cells. It plays a role in immunity, cancer, heart disease and Marfan syndrome.Some cells secrete TGF β, and also have receptors… … Wikipedia
TGF beta 1 — protein name=transforming growth factor, beta 1 caption= width= HGNCid=11766 Symbol=TGFB1 AltSymbols=TGFB, DPD1 EntrezGene=7040 OMIM=190180 RefSeq= UniProt= PDB= ECnumber= Chromosome=19 Arm=q Band=13.1 LocusSupplementaryData=Transforming growth… … Wikipedia
TGF beta 2 — Transforming growth factor beta 2 (TGF β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development (alternative names: Glioblastoma derived T cell suppressor factor, G TSF … Wikipedia
Transforming growth factor beta superfamily — Pfam box Symbol = TGF beta Name = Transforming growth factor beta like domain width = caption = Pfam= PF00019 InterPro= IPR001839 SMART= PROSITE= PDOC00223 SCOP = 1tfg TCDB = OPM family= OPM protein= PDB=PDB3|1ktzA:312 412 PDB3|1tgjA:312 412… … Wikipedia
Interleukin 8 receptor, beta — Chemokine (C X C motif) receptor 2 Identifiers Symbols CXCR2; CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB External IDs … Wikipedia
Transforming growth factor, beta 3 — Transforming growth factor, beta 3, also known as TGFB3, is a human gene.cite web | title = Entrez Gene: TGFB3 transforming growth factor, beta 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7043|… … Wikipedia