Rimantadine

drugbox
IUPAC_name = 1-(1-adamantyl)ethanamine



CAS_number = 13392-28-4
ATC_prefix = J05
ATC_suffix = AC02
PubChem = 5071
DrugBank = APRD01219
C = 12 |H = 21 |N = 1
molecular_weight = 179.302 g/mol
bioavailability = well absorbed
protein_bound = 40%
metabolism = Hepatic hydroxylation and glucuronidation
elimination_half-life = 25.4 ± 6.3 hours
excretion = Renal
pregnancy_category = C (U.S.)
legal_status = ℞-only (U.S.)
routes_of_administration = Oral

Rimantadine (INN, sold under the trade name Flumadine) is an orally administered antiviral drug used to treat, and in rare cases prevent, Influenzavirus A infection. When taken within one to two days of developing symptoms, rimantadine can shorten the duration and moderate the severity of influenza. It is a derivate of adamantane, like a similar drug amantadine. It was approved by the Food and Drug Administration (FDA) in 1994.

Mechanics

Scientists do not understand why rimantadine works, but believe it inhibits influenza's viral replication, possibly by preventing the uncoating of the virus's protective shells, which are the envelope and capsid. Genetic studies suggest that the virus M2 protein, an ion channel specified by virion M2 gene, plays an important role in the susceptibility of influenza A virus to inhibition by rimantadine. Resistance to rimantadine can occur as a result of an amino acid substitutions at certain locations in the transmembrane region of M2. This prevents binding of the antiviral to the channel.Facts|date=June 2007

Drug interactions

Taking paracetamol (acetaminophen e.g. Tylenol) or acetylsalicylic acid (aspirin) while taking rimantadine is known to reduce the body's uptake of rimantadine by approximately 12%. [http://www.fda.gov/cder/drug/antivirals/influenza/flumadine.htm] Cimetidine also affects the body's uptake of rimantadine.

Adverse effects

Rimantadine can produce gastrointestinal and central nervous system adverse effects. Studies have shown it produces fewer side effects than other anti-viral influenza treatments. Approximately 6% of patients (compared to 6% of patients taking a placebo) reported side effects. [http://www.cdc.gov/flu/professionals/treatment/side-effects.htm] Common side effects include:

*nausea
*upset stomach
*nervousness
*tiredness
*lightheadedness
*trouble sleeping
*difficulty concentrating

Other Uses

Rimantadine, like its antiviral cousin amantadine, possesses some NMDA antagonistic properties and is used as an antiparkinsonic drug (ie, in the treatment of Parkinson's Disease). However, neither rimantadine nor amantadine are preferred agents for this therapy and are generally reserved for cases of the disease which are less responsive to front-line treatments.

External links

* [http://www.fda.gov/bbs/topics/ANSWERS/ANS00530.html U.S. FDA press release announcing rimantadine's approval]
* [http://www.fda.gov/cder/drug/antivirals/influenza/flumadine.htm U.S. Center for Drug Evaluation and Research rimantadine description]
* [http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a698029.html U.S. NIH rimantadine description]
* [http://www.cdc.gov/flu/professionals/treatment/index.htm U.S. CDC flu anti-viral treatment information]


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