Oxprenolol

Oxprenolol
Systematic (IUPAC) name
(RS)-1-[2-(allyloxy)phenoxy]-3-(isopropylamino)propan-2-ol
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat. C(AU)
Legal status Prescription only
Routes oral
Pharmacokinetic data
Bioavailability 20-70%
Metabolism Hepatic
Half-life 1-2hours
Excretion Renal
Lactic (In lactiferous females)
Identifiers
CAS number 6452-71-7 YesY
ATC code C07AA02
PubChem CID 4631
DrugBank DB01580
ChemSpider 4470 YesY
UNII 519MXN9YZR YesY
KEGG D08318 YesY
ChEMBL CHEMBL546 YesY
Chemical data
Formula C15H23NO3 
Mol. mass 265.348
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Oxprenolol (Trasacor, Trasicor, Coretal, Laracor, Slow-Pren, Captol, Corbeton, Slow-Trasicor, Tevacor, Trasitensin, Trasidex) is a non-selective beta blocker with some intrinsic sympathomimetic activity. It is used for the treatment of angina pectoris, abnormal heart rhythms and high blood pressure.

Oxprenolol is a lipophilic beta blocker which passes the blood-brain barrier more easily than water soluble beta blockers. As such, it is associated with a higher incidence of CNS-related side effects than hydrophilic ligands such as atenolol, sotalol and nadolol.[1]

General Practitioners may sometimes be confused by its contrary nature as a beta agonist, but oxprenolol is a potent beta-blocker and should not be administered to asthmatics under any circumstances due to their low beta levels as a result of depletion due to other asthma medication, and because it can cause irreversible; often fatal; airway failure and inflammation.[2]

References

  1. ^ McDevitt DG (1987). "Comparison of pharmacokinetic properties of beta-adrenoceptor blocking drugs". Eur. Heart J.. 8 Suppl M: 9–14. PMID 2897304. 
  2. ^ I P Williams and F J Millard (1980). "Severe asthma after inadvertent ingestion of oxprenolol". Thorax 35 (2): 160. doi:10.1136/thx.35.2.160. PMC 471246. PMID 7376124. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=471246.