Befuraline

Drugbox
IUPAC_name = 1-benzofuran-2-yl- [4-(phenylmethyl)piperazin-1-yl] methanone


CAS_number = 41716-84-1
CAS_supplemental = 41717-30-0
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PubChem = 68664
DrugBank =
chemical_formula =
C=20 | H=20 | N=2 | O=2
molecular_weight = 320.38 g/mol
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Befuraline is a piperazine derivative drug invented in Germany in the 1970s. [ Boksay IJ, Popendiker K, Weber RO, Soder A. Synthesis and pharmacological activity of befuraline (N-benzo [b] furan-2-ylcarbonyl-N'-benzylpiperazine), a new antidepressant compound. Arzneimittel-Forschung. 1979;29(2):193-204. ] Befuraline has stimulant and antidepressant effects and has seen some use in Germany and France, although it has never become widely used. [ Gastpar M, Gastpar G, Gilsdorf U. Befuraline, its safety and efficacy in depressed inpatients. Pharmacopsychiatry. 1985 Nov;18(6):351-5. ] Befuraline has an active metabolite benzylpiperazine, which is responsible for its stimulant effects.

References


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