Fipexide

drugbox
IUPAC_name = 1- [4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl] -
2-(4-chlorophenoxy)ethanone


CAS_number = 34161-24-5
ATC_prefix = N06
ATC_suffix = BX05
PubChem = 3351
DrugBank =
C = 20 | H = 21 | Cl = 1 | N = 2 | O = 4
molecular_weight = 388.845 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration =

Fipexide is a piperazine derivative drug invented in Italy in 1983. [ Missale C, Pasinetti G, Govoni S, Spano PF, Trabucchi M. Fipexide: a new drug for the regulation of dopaminergic system at the macromolecular level. Bollettino Chimico Farmaceutico. 1983 Feb;122(2):79-85. ]

It was used as a nootropic drug in France and Italy, mainly for the treatment of senile dementia, [ Bompani R, Scali G. Fipexide, an effective cognition activator in the elderly: a placebo-controlled, double-blind clinical trial. Current Medical Research and Opinion. 1986;10(2):99-106. ] but is no longer in common use due to the occurrence of rare adverse drug reactions including fever [ Guy C, Blay N, Rousset H, Fardeau V, Ollagnier M. Fever caused by fipexide. Evaluation of the national pharmacovigilance survey. Therapie. 1990 Sep-Oct;45(5):429-31. ] and hepatitis. Fipexide is similar in action to other nootropic drugs such as piracetam and is structurally similar to another more well-known nootropic, centrophenoxine.

References


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • fipexide — noun A psychoactive piperazine drug formerly used as a nootropic …   Wiktionary

  • Benzylpiperazine — Systematic (IUPAC) name 1 benzylpiperazine …   Wikipedia

  • Nootropic — Nootropics (  /noʊ.ɵ …   Wikipedia

  • Piperazine — Piperazine[1] …   Wikipedia

  • Cyprodenate — Systematic (IUPAC) name 2 dimethylaminoethyl 3 cyclohexylpropanoate Clinical data AHFS/Drugs.com …   Wikipedia

  • Meclofenoxate — Systematic (IUPAC) name 2 Dimethylaminoethyl (4 chlorophenoxy)acetate Clinical data AHFS/Drugs.com …   Wikipedia

  • Releasing agent — Amphetamine, the prototypical releasing agent, which acts on norepinephrine and dopamine. A releasing agent (RA), or simply releaser, is a drug that induces the release of a neurotransmitter from the presynaptic neuron into the synapse, leading… …   Wikipedia

  • Norepinephrine releasing agent — Norepinephrine A norepinephrine releasing agent (NRA) is a type of drug which induces the release of norepinephrine and epinephrine from the pre synaptic neuron into the synapse. This in turn leads to increased extracellular concentrations of… …   Wikipedia

  • Amphetamine — For other uses, see Amphetamine (disambiguation). Amphetamine Systematic (IUPAC) name …   Wikipedia

  • Ciprofloxacin — Not to be confused with Cipralex, a brand name of the antidepressant escitalopram. Cipro redirects here. For the Rome Metro station, see Cipro (Rome Metro). Ciprofloxacin …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.