ImageFile1 = 2C-T8.png
ImageSize1 = 180px
ImageFile2 = 2C-T-8-3d-sticks.png
ImageSize2 = 200px
IUPACName = 2- [4- [(Cyclopropylmethyl)thio] -2,5-dimethoxyphenyl] ethanamine
Section1 = Chembox Identifiers
CASNo = 207740-27-0
SMILES = COc2cc(SCC1CC1)c(cc2CCN)OC
Section2 = Chembox Properties
Formula = C14H21NO2S
MolarMass = 267.39 g/mol
Section3 = Chembox Hazards
2C-T-8 is a
psychedelic phenethylamineof the 2C family. It was first synthesized by Alexander Shulgin, sometimes used as an entheogen.
The full name of the chemical is 2,5-di
methoxy-4- cyclopropyl methyl thio phenethylamine. The compound is reported to have a bad taste and smell.
In his book "PiHKAL (Phenethylamines i Have Known And Loved)", Shulgin lists the dosage range as 30 to 50 mg. 2C-T-8 is generally taken orally, and effects typically last 10 to 15 hours. Experiences have varied between
insightand creativityat low doses to hypersensitivityand paranoiaat higher doses. A "thinking-connection" that is characteristic of the 2C-Tgroup is evident in this chemical in stark contrast to the "pure euphoria" of phenethylamines such as MDMA. [CitePiHKAL]
2C-T-8 is unscheduled and uncontrolled in the United States, but possession and sales of 2C-T-8 will probably be prosecuted under the
Federal Analog Actbecause of its structural similarities to 2C-T-7. However, 2C-T-8, unlike many other phenethylamineshas not been sold by internet retailers. In the wake of Operation Web Trypin July 2004, the issue of possession and sales of 2C-T-8 and other similar chemicals will probably be resolved in the courtroom as will the fate of this rare but unique psychedelic. There have been no reported deaths from 2C-T-8.
The mechanism that produces 2C-T-8’s hallucinogenic and entheogenic effects has not been specifically established, however it is most likely to result from action as a 5-HT2A serotonin receptor
agonistin the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known.
The toxicity of 2C-T-8 is not well documented. 2C-T-8 is somewhat less potent than 2C-T-7, but it may be expected that at higher doses it would display similar toxicity to that of other phenethylamines of the 2C-T family. Other phenethylamine derivatives substituted with an alkylthio group at the 4 position such as
2C-T-7and 4-MTAare known to act as selective monoamine oxidaseA inhibitors, a side effect which can lead to lethal serotonin syndromewhen they are combined with stimulantdrugs.
There have been no confirmed deaths due to 2C-T-8Fact|date=March 2008, though this may in part be due to its rarity and limited usage. Of the 2C-T family, there have been a few confirmed deaths due to
2C-T-7, which involved either insufflating large (>30 mg) doses [ [http://www.erowid.org/chemicals/2ct7/2ct7_death1.shtml Erowid.org] ] [ [http://www.erowid.org/chemicals/2ct7/2ct7_death2.shtml Erowid.org] ] and in one case an unknown oral dose was combined with 200 mg MDMA. [ [http://www.erowid.org/chemicals/2ct7/2ct7_death3.shtml Erowid.org] ]
2C-T-8 is unknown on the black market. Limited accounts of 2C-T-8 can be found in the book
* [http://www.erowid.org/library/books_online/pihkal/pihkal044.shtml 2C-T-8 Entry in PiHKAL]
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