Systematic (IUPAC) name
Clinical data
Trade names Moban
AHFS/ Consumer Drug Information
MedlinePlus a682238
Pregnancy cat. C
Legal status Prescription only
Routes Oral
Pharmacokinetic data
Metabolism Hepatic
Half-life 1.5 hours
Excretion Minor, renal and fecal
CAS number 7416-34-4 YesY
ATC code N05AE02
PubChem CID 23897
IUPHAR ligand 207
DrugBank DB01618
ChemSpider 22342 YesY
KEGG D08226 YesY
Chemical data
Formula C16H24N2O2 
Mol. mass 276.374 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Molindone (Moban) is a therapeutic antipsychotic, used in the treatment of schizophrenia.[1] It works by blocking the effects of dopamine in the brain, leading to diminished psychoses. It is rapidly absorbed when taken by mouth.

It is sometimes described as a typical antipsychotic,[2] and sometimes described as an atypical antipsychotic.[3]

Molindone was discontinued by its sole supplier, Endo Pharmaceuticals, on January 13, 2010. [4]

Adverse effects

The side effect profile of molindone is similar to that of other typical antipsychotics. Unlike most antipsychotics, however, molindone use is associated with weight loss.[3][5]

See also

  • Losindole
  • Piquindone


  1. ^ "molindone". F.A. Davis Company. 
  2. ^ Aparasu RR, Jano E, Johnson ML, Chen H (October 2008). "Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients". Am J Geriatr Pharmacother 6 (4): 198–204. doi:10.1016/j.amjopharm.2008.10.003. PMID 19028375. 
  3. ^ a b Bagnall A, Fenton M, Kleijnen J, Lewis R (2007). Bagnall, Anne-Marie. ed. "Molindone for schizophrenia and severe mental illness". Cochrane Database Syst Rev (1): CD002083. doi:10.1002/14651858.CD002083.pub2. PMID 17253473. 
  4. ^
  5. ^ Allison DB, Mentore JL, Heo M et al. (1999). "Antipsychotic-induced weight gain: a comprehensive research synthesis". Am J Psychiatry 156 (11): 1686–96. PMID 10553730.  Free full text

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • molindone — noun A particular kind of therapeutic antipsychotic that is used to treat schizophrenia …   Wiktionary

  • molindone — mol·in·done mō lin .dōn n an antipsychotic drug used in the form of its hydrochloride C16H24N2O2·HCl esp. in the treatment of schizophrenia …   Medical dictionary

  • molindone — noun antipsychotic drug (trade name Moban) used in the treatment of schizophrenia • Syn: ↑Moban • Usage Domain: ↑trade name (for: ↑Moban) • Hypernyms: ↑major tranquilizer, ↑ …   Useful english dictionary

  • molindone hydrochloride — An antipsychotic. * * * mo·lin·done hy·dro·chlo·ride (mo linґdōn) [USP] a dihydroindolone antipsychotic agent, used especially in the treatment of schizophrenia, brief reactive psychosis, and schizophreniform disorders; administered orally …   Medical dictionary

  • Oxypertine — Systematic (IUPAC) name 5,6 dimethoxy 2 methyl 3 [2 (4 phenylpiperazin 1 yl)ethyl] 1H indole Clinical data AHFS/ …   Wikipedia

  • Antipsychotic — Advertisement for Thorazine (chlorpromazine) from the 1950s[1] An antipsychotic (or neuroleptic) is a tranquilizing psychiatric medication primarily used to manage psychosis (including delusions or hallucinations, as well as disordered tho …   Wikipedia

  • Phenothiazine — Phenothiazine …   Wikipedia

  • Clozapine — Not to be confused with clonazepam or Klonopin. Clozapine Systematic (IUPAC) name …   Wikipedia

  • Trifluoperazine — Systematic (IUPAC) name 10 [3 (4 methylpiperazin 1 yl)propyl] 2 (trifluoromethyl) 10H phenothiazine Clinical data AHFS/ …   Wikipedia

  • Chlorpromazine — Systematic (IUPAC) name …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.