Pyritinol

Drugbox
IUPAC_name = 1,2-bis(3-hydroxy-4-hydroxymethyl- 2-methylpyridin- 5-ylmethyl) disulfane



CAS_number=1098-97-1
ATC_prefix=N06
ATC_suffix=BX02
ATC_supplemental=
PubChem=14190
DrugBank=
C=16 | H=20 | N=2 | O=4 | S=2
molecular_weight = 368.473
bioavailability=
metabolism =
elimination_half-life= 2.5 hours
excretion =
pregnancy_category =
legal_status =
routes_of_administration=

Pyritinol also called pyridoxine disulfide or pyrithioxine (european drug names Encefabol, cerbon 6) is a semi-natural water soluble analog of vitamin B-6 (Pyridoxine hcl). It was produced in the 1961 by Merck Laboratories by bonding 2 B-6 compounds (pyridoxine) together with a disulfide bridge. Since the 1970's has been a prescription drug in several countries for cognitive disorders and learning disorders in children. Since the early 90's it has been sold as a dietary supplement in the US as a nootropic.

One small study with 12 subjects given pyritinol showed an improvement in performance on tests of reaction time, but not on memory tests. [cite journal |author=Hindmarch I, Coleston D, Kerr J |title=Psychopharmacological effects of pyritinol in normal volunteers |journal=Neuropsychobiology |volume=24 |issue=3 |pages=159–64 |year=1990 |pmid=2135070 |doi=10.1159/000119478]

It's approved European drug usage classifies it as " Other medicines of the cerebrospinal nervous system (II-13). XX Tablets, CERBON 6 is a pharmaceutical speciality with psychotonic and psychostimulating properties. It's approved uses are Functional insufficiencies of the SNC. Difficulties affecting concentration and memory. Poor academic performance. Physical and psychological exhaustion. Altered sleeping and waking rhythms. Symptoms related to senility and pre-senility. Cerebral arteriosclerosis. Chronic alcoholism.

Reference: http://www.antiaging-systems.com/apruses/pyritinol.htm

Pyritinol has been show to:

Enhance glucose transport through the blood-brain barrier

Be an an effective immune enhancer through its stimulation of neutrophil migration.

Increase nerve activity in the locus coeruleus

Reference: http://www.antiaging-systems.com/extract/encef.htm

Common dosages are 100-1,200 mg daily.

Side effects: Uncommon; nausea, headache. Rare; allergic reaction.

References


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