Aniracetam

Aniracetam
Systematic (IUPAC) name
1-[(4-methoxybenzoyl)]- 2-pyrrolidinone
Clinical data
Trade names Ampamet, Memodrin, Pergamid
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status Unscheduled
Routes Oral
Pharmacokinetic data
Half-life 1-2.5 hours
Identifiers
CAS number 72432-10-1 YesY
ATC code N06BX11
PubChem CID 2196
DrugBank DB04599
ChemSpider 2111 YesY
UNII 5L16LKN964 YesY
KEGG D01883 YesY
ChEBI CHEBI:47943 YesY
ChEMBL CHEMBL36994 YesY
Chemical data
Formula C12H13NO3 
Mol. mass 219.237 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Aniracetam (Draganon, Sarpul, Ampamet, Memodrin) is an ampakine and nootropic of the racetam chemical class purported to be considerably more potent than piracetam. It is lipid-soluble and has possible cognition-enhancing effects. It has been tested in animals extensively, Alzheimer's patients, and temporarily-impaired healthy subjects. It has shown potential as an anxiolytic in three clinical animal models. It is sold in Europe as a prescription drug.

Contents

Pharmacology

After a confirmed test of the anxiolytic efficacy in a mouse model, haloperidol, mecamylamine, and ketanserin were applied to determine the pathways aniracetam depends on to exert its anti-anxiety effects. Haloperidol completely reversed the anxiolytic effects, and mecamylamine and ketanserin nearly completely reversed the effects. This shows that aniracetam's anxiolytic mechanism is facilitated by D2/D3, nACh, and 5-HT2A receptors.[1]

Aniracetam has also been shown to selectively modulate the AMPA receptor[2] and was used as the parent compound to derive a class of drugs known as the ampakines that are being investigated as nootropics and neuroprotective drugs for the treatment of Alzheimer's disease and other neurodegenerative conditions.1

Despite the fat solubility of aniracetam, its half-life is much shorter than that of common racetam analogs such as piracetam.[citation needed]

Commonly used doses are 750-3,000 mg daily usually taken in 2-3 doses.

Side effects can include nausea and headache.[citation needed]

See also

References

  1. ^ Nakamura K; Kurasawa M (May 2001). "Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism". Eur J Pharmacol. (Kanagawa, Japan). 420 (1): 33–43. doi:10.1016/S0014-2999(01)01005-6. PMID 11412837. 
  2. ^ Ito et al. J. Physiol. 1990; 424: 533-543.

External links