IUPAC_name = "N"- [4-(1-hydroxy-2-isopropylamino-
ethyl)-phenyl] -methanesulfonamide

CAS_number = 3930-20-9
C=12 | H=20 | N=2 | O=3 | S=1
molecular_weight = 272.3624 g/mol
bioavailability = >95%
metabolism = Not metabolised
elimination_half-life = 12 hours
excretion = Renal
Lactic (In lactating females)
pregnancy_AU =
pregnancy_US = B
pregnancy_category =
legal_status = Rx-only
routes_of_administration = oral

Sotalol (trade names Betapace and Betapace AF, Berlex Laboratories, Sotalex and Sotacor, Bristol-Myers Squibb) is a drug used in individuals with rhythm disturbances (cardiac arrhythmias) of the heart, and to treat hypertension in some individuals.


It falls into the class III antiarrhythmic agents because it inhibits the potassium ion channels in the heart. It is also a beta blocker because of its action on the β-adrenergic receptors in the heart.cite journal |author=Kulmatycki KM, Abouchehade K, Sattari S, Jamali F |title=Drug-disease interactions: reduced beta-adrenergic and potassium channel antagonist activities of sotalol in the presence of acute and chronic inflammatory conditions in the rat |journal=Br. J. Pharmacol. |volume=133 |issue=2 |pages=286–94 |year=2001 |month=May |pmid=11350865 |pmc=1572777 |doi=10.1038/sj.bjp.0704067 |url=]

By blocking the potassium channels, sotalol prolongs repolarization, therefore lengthening the QT interval and decreasing automaticity.

It also slows atrioventricular (AV) nodal conduction (beta-blocking effect).

Sotalol is a racemic mix of D and L enantiomers. The L isomer is a beta blocker.

Sotalol is not selected for its beta-blocking ability, but rather for its Class III (potassium blocking) properties.


Sotalol is used to treat ventricular tachycardiascite journal |author=Boriani G, Lubinski A, Capucci A, "et al" |title=A multicentre, double-blind randomized crossover comparative study on the efficacy and safety of dofetilide vs sotalol in patients with inducible sustained ventricular tachycardia and ischaemic heart disease |journal=Eur. Heart J. |volume=22 |issue=23 |pages=2180–91 |year=2001 |month=December |pmid=11913480 |doi= |url=] as well as atrial fibrillation. [PMID 15872201] Betapace AF is specifically labeled for atrial fibrillation.

Some evidence suggests that sotalol should be avoided in the setting of decreased ejection fraction due to heart attack. [cite journal | author = Waldo A, Camm A, deRuyter H, Friedman P, MacNeil D, Pauls J, Pitt B, Pratt C, Schwartz P, Veltri E | title = Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol | journal = Lancet | volume = 348 | issue = 9019 | pages = 7–12 | year = 1996 | pmid = 8691967 | doi = 10.1016/S0140-6736(96)02149-6]

It has also been suggested that it be used in the prevention of atrial fibrillation.cite journal |author=Patel A, Dunning J |title=Is Sotalol more effective than standard beta-blockers for the prophylaxis of atrial fibrillation during cardiac surgery |journal=Interact Cardiovasc Thorac Surg |volume=4 |issue=2 |pages=147–50 |year=2005 |month=April |pmid=17670378 |doi=10.1510/icvts.2004.102152 |url=]


ee also

*Antiarrhythmic agents
*Beta blocker

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Look at other dictionaries:

  • Sotalol — Nombre (IUPAC) sistemático (RS) N {4 [1 hidroxi 2 (propan 2 ilamino)etil]f …   Wikipedia Español

  • Sotalol — Strukturformel (R) Sotalol (oben) und (S) Sotalol (unten), 1:1 Stereoisomerengemisch …   Deutsch Wikipedia

  • sotalol — noun A drug used to treat cardiac arrhythmia and hypertension …   Wiktionary

  • sotalol — so·ta·lol sōt ə .lȯl, .lōl n a beta adrenergic blocking agent administered in the form of its hydrochloride C12H20N2O3S·HCl to treat ventricular arrhythmias * * * n. a drug (see beta blocker) used to treat abnormal heart rhythm. It is… …   Medical dictionary

  • sotalol — n. a drug (see beta blocker) used to treat and prevent abnormal heart rhythm (see arrhythmia). It is administered by mouth or injection; side effects may include digestive upsets, tiredness, and dizziness. Trade names: Beta Cardone, Sotacor …   The new mediacal dictionary

  • sotalol — …   Useful english dictionary

  • sotalol hydrochloride — A β receptor blocking agent with uses similar to those of propranolol; also possesses potassium channel blocking properties. * * * so·ta·lol hy·dro·chlo·ride (soґtə lol) a non cardioselective beta adrenergic blocking agent used in the… …   Medical dictionary

  • Соталол (Sotalol) — лекарственное вещество (см. Бета блокатор), применяемое для лечения нарушений сердечного ритма, стенокардии и повышенного артериального давления, а также для уменьшения проявлений тиреотоксикоза. Может назначаться внутрь или в инъекциях;… …   Медицинские термины

  • Соталол — Sotalol1 : 1 mixture (racemate) (Sotalol) Химическое соединение …   Википедия

  • SVTS — Sotalol Ventricular Tachycardia Study …   Medical dictionary

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