Capnocytophaga canimorsus

name = Capnocytophaga
regnum = Bacteria
phylum = Bacteroidetes
classis = Flavobacteria
ordo = Flavobacteriaceae
familia = Flavobacteriaceae
genus = Capnocytophaga
species = "C. canimorsus"
species_authority = Brenner "et al", 1990
binomial = "Capnocytophaga canimorsus"

"Capnocytophaga canimorsus" is a Gram-negative bacillus (rod-shaped) bacterium that causes a zoonotic disease, most commonly in asplenic patients. It is a member of the normal gingival flora of dogs and cats. It causes fulminant sepsis with disseminated intravascular coagulation (DIC).


Treatment is via antibiotics with the possible aid of activated protein C or plasmapheresis in severe cases.

Following animal bites, co-amoxiclav is often given to asplenic individuals to prevent disseminated infection; but in patients who are allergic to penicillins, the combination of doxycycline and metronidazole (to cover anaerobic organisms) may be used instead.

In patients with sepsis, treatment with imipenem, clindamycin, or a penicillin-β-lactamase inhibitor combination (e.g., co-amoxiclav or piperacillin-tazobactam) should be used. [cite journal | title=Antimicrobial treatment of Capnocytophaga infections | author=Jolivet-Gougeon A, Sixou J, Tamanai-Shacoori Z, Bonnaure-Mallet M | journal=Int J Antimicrob Agents | year=2007 | volume=29 | issue=4 | pages=367–373 | doi=10.1016/j.ijantimicag.2006.10.005 ] Doxycycline is active "in vitro" [cite journal | author=Chraibi DI, Girond S, Michel G | title=Evaluation of the activity of four antimicrobial agents using an in vitro rapid micromethod against oral streptococci and various bacterial strains implicated in periodontitis | journal=J Periodontal Res | year=1990 | volume=25 | issue=4 | pages=201–6 | pmid=2142728 | doi=10.1111/j.1600-0765.1990.tb00905.x ] [cite journal | author=Heimdahl A, Nord CE | title=Antimicrobial agents in the treatment of periodontal diseases: special aspects on tetracycline and doxycycline | journal=Scand J Infect Dis Suppl | year=1988 | volume=53 | pages=35–45 | pmid=3047856 ] but there is little experience in using it in treating sepsis, and in many countries there is no intravenous form available, which suggests that it should be reserved for when no other options are available.

"Capnocytophaga canimorsus" was previously known as "dysgonic fermenter type 2" (DF2).


External links

* [ Animal bite infections (]

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