Pituitary adenylate cyclase activating peptide

Adenylate cyclase activating polypeptide 1 (pituitary), also known as ADCYAP1, is a human gene.cite web | title = Entrez Gene: ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116| accessdate = ]

Pituitary adenylate cyclase activating peptide is a peptide similar to vasoactive intestinal peptide. One of its effects is to stimulate enterochromaffin-like cells.

It binds to vasoactive intestinal peptide receptor.

section_title =
summary_text = This gene encodes adenylate cyclase activating polypeptide 1. Mediated by adenylate cyclase activating polypeptide 1 receptors, this polypeptide stimulates adenylate cyclase and subsequently increases the cAMP level in target cells. Adenylate cyclase activating polypeptide 1 is not only a hypophysiotropic hormone, but also functions as a neurotransmitter and neuromodulator. In addition, it plays a role in paracrine and autocrine regulation of certain types of cells. This gene is composed of five exons. Exons 1 and 2 encode the 5' UTR and signal peptide, respectively; exon 4 encodes an adenylate cyclase activating polypeptide 1-related peptide; and exon 5 encodes the mature peptide and 3' UTR. This gene encodes three different mature peptides, including two isotypes: a shorter form and a longer form.cite web | title = Entrez Gene: ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116| accessdate = ]

ee also

* Adenylate cyclase
* Pituitary gland


Further reading

citations =
*cite journal | author=Geng L, Ju G |title= [The discovery of pituitary adenylate cyclase activating polypeptide (PACAP) and its research progress] |journal=Sheng li ke xue jin zhan [Progress in physiology] |volume=28 |issue= 1 |pages= 29–34 |year= 2000 |pmid= 10921074 |doi=
*cite journal | author=Fahrenkrug J |title=Gut/brain peptides in the genital tract: VIP and PACAP. |journal=Scand. J. Clin. Lab. Invest. Suppl. |volume=234 |issue= |pages= 35–9 |year= 2002 |pmid= 11713978 |doi=
*cite journal | author=Waschek JA |title=Multiple actions of pituitary adenylyl cyclase activating peptide in nervous system development and regeneration. |journal=Dev. Neurosci. |volume=24 |issue= 1 |pages= 14–23 |year= 2002 |pmid= 12145407 |doi=
*cite journal | author=Fahrenkrug J |title=PACAP--a multifacetted neuropeptide. |journal=Chronobiol. Int. |volume=23 |issue= 1-2 |pages= 53–61 |year= 2006 |pmid= 16687279 |doi= 10.1080/07420520500464569
*cite journal | author=Conconi MT, Spinazzi R, Nussdorfer GG |title=Endogenous ligands of PACAP/VIP receptors in the autocrine-paracrine regulation of the adrenal gland. |journal=Int. Rev. Cytol. |volume=249 |issue= |pages= 1–51 |year= 2006 |pmid= 16697281 |doi= 10.1016/S0074-7696(06)49001-X
*cite journal | author=Nakata M, Yada T |title=PACAP in the glucose and energy homeostasis: physiological role and therapeutic potential. |journal=Curr. Pharm. Des. |volume=13 |issue= 11 |pages= 1105–12 |year= 2007 |pmid= 17430174 |doi=
*cite journal | author=Felley CP, Qian JM, Mantey S, "et al." |title=Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release. |journal=Am. J. Physiol. |volume=263 |issue= 6 Pt 1 |pages= G901–7 |year= 1993 |pmid= 1335692 |doi=
*cite journal | author=Inooka H, Endo S, Kitada C, "et al." |title=Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues. Conformation determined by 1H NMR and CD spectroscopies and distance geometry in 25% methanol solution. |journal=Int. J. Pept. Protein Res. |volume=40 |issue= 5 |pages= 456–64 |year= 1993 |pmid= 1483839 |doi=
*cite journal | author=Hosoya M, Kimura C, Ogi K, "et al." |title=Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. |journal=Biochim. Biophys. Acta |volume=1129 |issue= 2 |pages= 199–206 |year= 1992 |pmid= 1730060 |doi=
*cite journal | author=Ohkubo S, Kimura C, Ogi K, "et al." |title=Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide. |journal=DNA Cell Biol. |volume=11 |issue= 1 |pages= 21–30 |year= 1992 |pmid= 1739432 |doi=
*cite journal | author=Kimura C, Ohkubo S, Ogi K, "et al." |title=A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. |journal=Biochem. Biophys. Res. Commun. |volume=166 |issue= 1 |pages= 81–9 |year= 1990 |pmid= 2302217 |doi=
*cite journal | author=Cross SH, Charlton JA, Nan X, Bird AP |title=Purification of CpG islands using a methylated DNA binding column. |journal=Nat. Genet. |volume=6 |issue= 3 |pages= 236–44 |year= 1994 |pmid= 8012384 |doi= 10.1038/ng0394-236
*cite journal | author=Inagaki N, Yoshida H, Mizuta M, "et al." |title=Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 7 |pages= 2679–83 |year= 1994 |pmid= 8146174 |doi=
*cite journal | author=Ohtaki T, Masuda Y, Ishibashi Y, "et al." |title=Purification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26650–7 |year= 1994 |pmid= 8253796 |doi=
*cite journal | author=Pérez-Jurado LA, Francke U |title=Dinucleotide repeat polymorphism at the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. |journal=Hum. Mol. Genet. |volume=2 |issue= 6 |pages= 827 |year= 1993 |pmid= 8353512 |doi=
*cite journal | author=Weber B, Riess O, Daneshvar H, "et al." |title=(CA)n-dinucleotide repeat at the PDEB locus in 4p16.3. |journal=Hum. Mol. Genet. |volume=2 |issue= 6 |pages= 827 |year= 1993 |pmid= 8394765 |doi=
*cite journal | author=Wray V, Kakoschke C, Nokihara K, Naruse S |title=Solution structure of pituitary adenylate cyclase activating polypeptide by nuclear magnetic resonance spectroscopy. |journal=Biochemistry |volume=32 |issue= 22 |pages= 5832–41 |year= 1993 |pmid= 8504103 |doi=
*cite journal | author=Gourlet P, Vandermeers A, Robberecht P, Deschodt-Lanckman M |title=Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP-27, but not PACAP-38) degradation by the neutral endopeptidase EC |journal=Biochem. Pharmacol. |volume=54 |issue= 4 |pages= 509–15 |year= 1997 |pmid= 9313778 |doi=
*cite journal | author=Zeng N, Athmann C, Kang T, "et al." |title=PACAP type I receptor activation regulates ECL cells and gastric acid secretion. |journal=J. Clin. Invest. |volume=104 |issue= 10 |pages= 1383–91 |year= 1999 |pmid= 10562300 |doi=
*cite journal | author=Dautzenberg FM, Mevenkamp G, Wille S, Hauger RL |title=N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants. |journal=J. Neuroendocrinol. |volume=11 |issue= 12 |pages= 941–9 |year= 2000 |pmid= 10583729 |doi=

External links


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