Mebeverine

Mebeverine
Systematic (IUPAC) name
(RS)-4-(ethyl[1-(4-methoxyphenyl)propan-2-yl]amino)butyl 3,4-dimethoxybenzoate
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status POM (UK)
Routes Oral
Identifiers
CAS number 2753-45-9
ATC code A03AA04
PubChem CID 4031
ChemSpider 3891 YesY
UNII 7F80CC3NNV YesY
KEGG D04868 YesY
ChEMBL CHEMBL282121 YesY
Chemical data
Formula C25H35NO5 
Mol. mass 429,6[g/mol]
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Mebeverine is a musculotropic antispasmodic drug without atropic side-effects whose major therapeutic role is in the treatment of irritable bowel syndrome. It is also indicated for treatment of gastrointestinal spasm secondary to organic disorder. It was first registered in 1965. It is manufactured and marketed as Colofac, Duspatal and Duspatalin by Solvay Pharmaceuticals.

Mebeverine is presented in the United Kingdom as a (135 mg) tablet. Other strengths: 100 mg tablet and 200 mg capsule.

Mebeverine(Colona) 135mg, Bought U.K.

Contents

Mode of action

Mebeverine is an antimuscarinic. Mebeverine belongs to a group of compounds called musculotropic antispasmodics. These compounds act directly on the gut muscles at the cellular level to relax them. Mebeverine is also an inhibitor of calcium-depot replenishment. Therefore, mebeverine has dual mode of action which normalizes the small bowel motility.

Indications

Spastic functional disturbances of the colon:

  • Irritable bowel syndrome in its primary form
  • Irritable bowel syndrome associated with organic lesions of the gastrointestinal tract such as; diverticulosis and diverticulitis, regional enteritis, disease of the gall bladder and gall ducts, gastric and duodenal ulcers, dysentery, and aspecific or specific inflammation of the digestive tract.
  • mebeverine should be taken 20 minutes before meals.

Adverse effects

Since 1978, 21 cases of severe adverse reactions to mebeverine were reported in the Netherlands.[1] Most reactions consisted of urticaria or maculopapular rash, sometimes accompanied by fever, polyarthritis, thrombopenia or angioedema.

Listed side effects

Very rarely, people taking this medicine may develop allergic reactions.[2]

References

  1. ^ in 't Veld BA, van Puyenbroek E, Stricker BH. (1997). Hypersensitivity reactions to use of mebeverine. pp. 1392–5.  Ned Tijdschr Geneeskd. 1997 July 12;141(28):1392-5. Hypersensitivity reactions to use of mebeverine [1] pubmed: 9380201
  2. ^ Colofac Patient leaflet sheet http://emc.medicines.org.uk/medicine/2531/PIL/Colofac+Tablets+135mg/