- Lim Kinases
LIM kinase-1 (
LIMK1) and LIM kinase-2 ( LIMK2) are actin-binding kinases that phosphorylate members of the ADF/ cofilinfamily of actin binding and filament severing proteins. ADF/cofilin are the only substrates yet identified for the LIM kinases. Upstream, LIMK1 is regulated by Pak1 (Edwards et al, 1999), and LIMK2 by the Rho-dependent kinase ROCK (Sumi et al, 2001). Lim Kinases are activated by PAK (p21-activated kinase).
There are approximately 40 known eukaryotic LIM
proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zincfingers. Although zinc fingers usually function by binding to DNAor RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinasedomain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3984 NIH]
#Aizawa, H., Wakatsuki, S., Ishii, A., Moriyama, K., Sasaki, Y., Ohashi, K., Sekine-Aizawa, Y., Sehara-Fujisawa, A., Mizuno, K., Goshima, Y. & Yahara, I. (2001) Phosphorylation of cofilin by LIM kinase is necessary for semaphorin 3A-induced growth cone collapse., Nature Neuroscience. 4, 367-373.
#Amano, T., Tanabe, K., Eto, T., Narumiya, S. & Mizuno, K. (2001) LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phopshorylation at threonine-505., Biochem. J. 354, 149-159.
#Edwards, D.C., Sanders, L.C., Bokoch, G.M. & Gill, G.N. (1999) Nature Cell Biol. 1, 253-259.
#Sumi, T., Matsumoto, K. & Nakamura, T. (2001). "Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase." J.Biol.Chem. 276(1), 670-676.
# [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3984 NIH] LIMK1 LIM domain kinase 1 Homo sapiens
Wikimedia Foundation. 2010.
Look at other dictionaries:
LIMK1 — LIM domain kinase 1, also known as LIMK1, is a human gene. PBB Summary section title = summary text = There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine… … Wikipedia
LIMK2 — LIM domain kinase 2, also known as LIMK2, is a human gene.cite web | title = Entrez Gene: LIMK2 LIM domain kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3985| accessdate = ] PBB Summary section… … Wikipedia
Cofilin 1 — (non muscle) PDB rendering based on 1q8g … Wikipedia
CDC42BPA — CDC42 binding protein kinase alpha (DMPK like), also known as CDC42BPA, is a human gene.cite web | title = Entrez Gene: CDC42BPA CDC42 binding protein kinase alpha (DMPK like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… … Wikipedia
Actin-binding protein — Actin binding proteins (also known as ABP) are proteins that bind to actin. This may mean ability to bind actin monomers, or polymers, or both.Many actin binding proteins, including α actinin, β spectrin, dystrophin, utrophin and fimbrin, do this … Wikipedia
p53 — For the band and album of the same name, see P53 (band) and P53 (album). Tumor protein p53 PDB rendering based on 1TUP … Wikipedia
CHEK1 — CHK1 checkpoint homolog (S. pombe) PDB rendering based on 1ia8 … Wikipedia
Chemical biology — is a scientific discipline spanning the fields of chemistry and biology that involves the application of chemical techniques and tools, often compounds produced through synthetic chemistry, to the study and manipulation of biological systems.… … Wikipedia
DYRK1B — Dual specificity tyrosine (Y) phosphorylation regulated kinase 1B Identifiers Symbols DYRK1B; MIRK External IDs … Wikipedia
Ataxia telangiectasia and Rad3 related — Identifiers Symbols ATR; FRP1; MEC1; SCKL; SCKL1 External IDs … Wikipedia