Eli Lilly and Company
company_name = Eli Lilly and Company
company_type = Public (
NYSE: [http://www.nyse.com/about/listed/lcddata.html?ticker=LLY LLY] )
foundation = 1876
company_slogan = "Answers that matter"
Indianapolis, Indiana, USA
Sidney Taurel, Chairman
John C. Lechleiter, President & CEO
Derica Rice, CFO
Eli Lilly, Founder
Cialis, Strattera, Darvocet
revenue = profit$18.633 billion USD (2007)
num_employees = 40,600 (2007)
homepage = [http://www.lilly.com/ www.lilly.com]
Eli Lilly and Company (nyse|LLY) is a global
pharmaceuticalcompany and one of the world's largest corporations. Eli Lilly's global headquarters is located in Indianapolis, Indiana, in the United States. The company was founded in 1876 by a pharmaceutical chemist, Eli Lilly, after whom the company was ultimately named.
Fortune 500corporation, Eli Lilly had revenues of $18.6 billion in 2007, making it the 148th largest company in the United States and the 10th largest corporation by global pharmaceutical sales. The company is publicly traded on the New York Stock Exchangeand is a member of the S&P 500stock index. Eli Lilly is one of the Nifty Fiftystocks that propelled the late 20th century bull market.
Eli Lilly is a full member of the
European Federation of Pharmaceutical Industries and Associations(EFPIA). [cite news|url=http://www.efpia.eu/content/default.asp?PageID=559&DocID=4883|title=The Pharmaceutical Industry in Figures - 2008 Edition |publisher=European Federation of Pharmaceutical Industries and Associations (EFPIA)|pages=49|language=english|accessdate=2008-08-25]
Eli Lilly and Company grew from a tiny laboratory in Indianapolis in 1876 to one of the world's largest pharmaceutical companies.
Colonel Eli Lilly, a pharmacist who had served as a Union officer in the
American Civil War, acquired a laboratory on Pearl Street in Indianapolis in 1876 and started Eli Lilly and Company. His innovative process of gelatin-coating pills helped establish the success of the company. When Eli Lilly died in 1898, his son Josiah K. Lilly Sr.took control of the company. Josiah inherited his father's civic mindedness and ordered the company to send much needed medicine to support recovery efforts following the 1906 San Francisco earthquake.
In 1919, Lilly hired biochemist George Henry Alexander Clowes as director of biochemical research. Clowes' negotiations with researchers who developed
insulinat the University of Torontohelped launch the first successful large-scale production of insulin in 1923. The success of insulin enabled the company to attract well-respected scientists and, with them, make more medical advances.
Eli Lilly, the grandson of Col. Lilly, was named as the company's president in 1932. In 1934, the company made its first venture overseas when a Lilly office was opened in
England. World War IIbrought production at Lilly to a new high with the manufacturing of Merthiolateand blood plasma. In 1943, the company began full-scale production of penicillin.
Eli Lilly International Corp. was formed in 1943 as a subsidiary to encourage business trade abroad. In 1945, the company opened a new plant on South Kentucky Avenue in Indianapolis and, by 1948, Lilly employed nearly 7,000 people. Also in 1948, Eli Lilly relinquished the presidency to his brother Josiah Lilly Jr. In 1952, the first public shares of stock were offered and, in 1953, Eugene N. Beesley was named president. He was the first non-family member to run the company.
In 1953 the
Central Intelligence Agencygave Eli Lilly Company a $400,000 grant to manufacture and supply lysergic acid diethylamide(LSD) for the CIA.Fact|date=August 2008 This was the first mass production of the chemical, and was used by a branch of the CIA known as MKULTRA.Fact|date=August 2008
Lilly continued to expand. In 1950, Tippecanoe Laboratories, in
Lafayette, Indiana, increased antibioticproduction with its patent on erythromycin. In 1954, Elanco Products Co. was formed for the production of veterinarypharmaceuticals. In 1963, with an acquisition from Distillers Company, the company established a major factory in Liverpool. In 1969, the company opened a new plant in Clinton, Indiana. In 1968, Lilly Research Centre Ltd. near London, England was built. It was the company's first research facility outside the United States.
Lilly made an uncharacteristic, but ultimately profitable, move in 1971 when it bought cosmetic manufacturer
Elizabeth Ardenfor $38 million. Sixteen years later, Lilly sold Arden to Fabergé in 1987 for $657 million.
Richard Wood was named CEO of Lilly in 1973. During the 1970s and 1980s, Eli Lilly and Company saw a flurry of drug production: antibiotic
Keflexin 1971; heart drug Dobutrex in 1977; Ceclor, which would become the world's top selling oral antibiotic, in 1979; leukemiadrug Eldisine; antiarthritic Oraflex; and analgesic Darvon.
Lilly ventured into medical instruments through the acquisition of IVAC Corp., which manufactures vital signs and
intravenousfluid infusion monitoring systems. Lilly also purchased Cardiac Pacemaker, a manufacturer of heart pacemakers.
In 1989, a joint agri-chemical venture between Elanco Products Co. and
Dow Chemicalcreated DowElanco. In 1997, Lilly sold its 40 percent share in the company to Dow Chemical for $1.6 billion.
In 1991, Vaughn Bryson was named CEO of Eli Lilly. During his 18-month tenure, the company reported its first quarterly loss ever.
Randall L. Tobias, former vice-chairman of AT&T, was named Bryson's replacement in 1993. He was the first official recruited outside of the company. Sidney Taurel, former chief operating officer of Lilly was named CEO in 1998, replacing Tobias. Taurel was named chairman in January 1999.
Eli Lilly announced a major expansion plan in July 1999, totaling $1 billion and expected to create 7,500 jobs over 10 years, but Lilly lost exclusive rights to Prozac in 2001 and profits fell drastically. With this job creation announcement, the state of Indiana agreed to give several hundreds of millions of dollars to Eli Lilly in the form of tax abatements and other grants. Lilly, however, has failed to comply with this plan and has actually cut jobs dramatically (2007). Lilly has kept the money, but has never formed any new jobs as they first announced. The current governor,
Mitch Daniels, used to be an executive at Eli Lilly, and has chosen not to investigate the matter, even though it has cost tax payers hundreds of millions of dollars. The company has since made a comeback with sales on Zyprexaand Cymbalta.
In 1998, Eli Lilly formed a joint venture with ICOS Corporation, a
Bothell, Washingtonbased biotechnology company, to develop and commercialize Cialis for the treatment of erectile dysfunction. In October 2006, Eli Lilly announced its intention to acquire ICOS, for $2.1 billion, or $32 a share. The initial attempt to acquire ICOS failed under pressure from large institutional shareholders, causing Lilly to offer $34 per share. ISS, a proxy advisory firm, advised ICOS shareholders to reject the proposal as undervalued. However, the acquisition was approved by ICOS shareholders and Eli Lilly completed its acquisition of the company on January 29, 2007. Since ICOS had no other products in development beyond Cialis, Eli Lilly promptly closed ICOS operations and terminated nearly 500 ICOS employees, except for 127 employees working at the biologics facility. In December 2007, CMC Biopharmaceuticals A/S (CMC), a Copenhagen, Denmark-based provider of contract biomanufacturing services, bought the Bothell-based biologics facility from Eli Lilly and retained the existing 127 employees.
In addition to internal research and development activities Eli Lilly is also involved in publicly funded collaborative research projects, with other industrial and academic partners. One example in the area of non-clinical safety assessment is the
InnoMed PredTox. [Mattes WB (2008), Public consortium efforts in toxicogenomics, Methods Mol Biol. 2008;460:221-38 [http://www.ncbi.nlm.nih.gov/pubmed/18449490] ] cite web|url=http://www.innomed-predtox.com/consortium/members/|title=InnoMed PredTox Member Organizations|accessdate=2008-08-25] The company is expanding its activities in joint research projects within the framework of the Innovative Medicines Initiativeof EFPIAand the European Commission.cite web|url=http://imi.europa.eu/docs/calls01_en.zip|title=IMI Call Topics 2008|last=Innovative Medicines Initiative|work=IMI-GB-018v2-24042008-CallTopics.pdf|publisher=European Commission|accessdate=2008-08-25]
Among the company's major pharmaceutical breakthroughs are
cephalosporin, erythromycin, insulin, and Prozac(fluoxetine), a selective serotonin reuptake inhibitorfor the treatment of clinical depression.
Among other distinctions, Lilly is the world's largest manufacturer and distributor of medications used in a broad range of psychiatric and
mental health-related conditions, including clinical depression, generalized anxiety disorder, narcoticaddiction, insomnia, bipolar disorder, schizophrenia, and others.
In 2003, Eli Lilly introduced Cialis (tadalafil), a competitor to
Pfizer's blockbuster Viagrafor erectile dysfunction. Cialis maintains an active period of 36 hours, causing it sometimes to be dubbed the " weekend pill". Cialis was developed in a partnership with biotechnologycompany ICOS. On December 18, 2006Lilly bought ICOS in order to gain full control of the product.
With its television advertisement for Cialis during the 2004 Super Bowl Halftime Show, Eli Lilly was one of several companies whose costly 2004
Super BowlHalftime advertisements were largely overshadowed by the Janet Jacksonand Justin Timberlake Super Bowl XXXVIII halftime show controversy.
Another Lilly manufactured anti-depressant, Cymbalta, a
serotonin-norepinephrine reuptake inhibitorused predominantly in the treatment of major depressive disorders and generalized anxiety disorder, ranks with Prozac as one of the most financially successful pharmaceuticals in industry history.
In 1996, the
FDAapproved Gemzar for the treatment of pancreatic cancer. Gemzar is commonly used in the treatment of pancreatic cancer (usually in coordination with 5-FU chemotherapyand radiology). Gemzar also is routinely used in the treatment of non-small cell lung cancer.
Eli Lilly was the first distributor of
methadone, an analgesicused frequently in the treatment of heroin, opiumand other opioidand narcotic drug addictions.
Over the years there have been many accusations by patients and their families of SSRIs causing suicidal ideation and aggressive (or homicidal) behavior. The scientific evidence supporting this claim has been criticized by drug advocates, but alternative medicine sites often claim that patients committed suicide or engaged in aggressive and / or criminal acts using SSRIs. Manufacturers of SSRIs historically have vehemently denied any such link and have always blamed the disease rather than the treatment.
In the United States there is a required box warning for suicide risk in children. In the UK, all "antidepressant" medications except Prozac have been banned for people under 18. In late 2004 the first U.S. black box warning was added which applied only to children 12 and under. Recently experts recommended expanding the warning to adults. In general the risk of suicide is twice as great when taking an SSRI regardless of the type of diagnosis or whether the patient was considered a healthy volunteer for trial purposes.
On Dec 13, 2006, a U.S. Food and Drug Administration advisory panel recommended that "black-box" warnings on SSRIs be raised from 18 to 25 years old. The FDA is not obliged to follow the recommendations of its advisory committees but usually does.
An October 2006 study promoted the idea that SSRIs may decrease youth suicide overall.  A more recent study  released in November 2006, however concluded only "The aggregate nature of these observational data precludes a direct causal interpretation of the results. More SSRI prescriptions... may reflect antidepressant efficacy".
According to these facts, antidepressant prescriptions for children increased by almost 8% in the first six months of 2004, if this is the case, it is difficult to link an increased suicide rate the same year to reduced use of antidepressants.
So despite the suggestions of a connection between the drop in SSRI prescriptions (even this fact is a matter of debate) and the spike in child and teen suicides, much more research will be needed before a conclusive link can be drawn.
In fact the only SSRI that is licensed for use in children in the UK and USA is Prozac. All other SSRIs have been banned from paediatric use as their safety and efficacy have not been proven. Even of its own paediatric trials of Seroxat, Glaxo said  “"The best which could have been achieved was a statement that although safety data was reassuring, efficacy had not been demonstrated."
A September 2007 study, to be published in American Journal of Psychiatry suggests newer antidepressants led to more suicides in teenagers. 
Prozac has been a breakthrough therapy, and was one of the first such therapies in its class to treat clinical depression by blocking the uptake of
serotoninwithin the human brain.
Prozac has given rise to a number of comparably-functioning therapies for the treatment of clinical depression and other
central nervous systemdisorders such as obsessive compulsive disorder, bulimia nervosa, and panic disorders. Prozac works by inhibiting the reuptake of serotonin in the human brain. It is prescribed to more than fifty-four million people worldwide.
Prozac in popular culture
Because of its wide appeal as a popular anti-depressant, Prozac has had numerous references to it in popular culture, including many books, movies, and songs. The autobiographical book "Prozac Nation" was authored in 1994 by
Elizabeth Wurtzel; it was turned into a movie of the same name, "Prozac Nation", in 2001, starring Christina Ricci. A 1993 book, "Listening to Prozac", was a generally critical look at Prozac and its side effects. Another book, "Talking Back to Prozac", also focuses on Prozac side effects. Vanilla Icehas a song called "Prozac." The British band Killing Jokehas a song called "Prozac People." Rap artist Jay-Zmakes reference to Prozac in his song "Nigga What, Nigga Who."
Eli Lilly has manufactured
Secobarbital, a barbituratederivative with anaesthetic, anticonvulsant, sedativeand hypnotic properties. Lilly marketed Secobarbital under the brand name Seconal.
Secobarbital is indicated for the treatment of
epilepsy, temporary insomniaand as a pre-operative medication to produce anaesthesia and anxiolysisin short surgical, diagnostic, or therapeutic procedures which are minimally painful. With the onset of new therapies for the treatment of these conditions, Secobarbital has been less utilized, and Lilly ceased manufacturing it in 2001.
Secobarbital gained considerable attention during the 1970s, when it gained popularity as a recreational drug. On September 18, 1970, rock guitarist legend
Jimi Hendrixdied from a secobarbital overdose. On June 22, 1969 secobarbital overdose was the cause of death of actress Judy Garland. The drug was a central part of the plot of the hugely popular novel " The Valley of the Dolls" by Jacqueline Susannin which three highly successful Hollywood women each fall victim, in various ways, to the drug. The novel was later released as a film by the same name.
Eli Lilly has developed the controversial
vaccinepreservative Thiomersal(also called Merthiolate). Thimerosal is effectual by causing susceptible bacteria to autolyze.
Additional Eli Lilly therapies
mesotheliomaand non-small cell lung cancer).
*Byetta (for Type 2 diabetes) (co-marketed with
*Cymbalta (for diabetic neuropathic pain,
major depressive disorders and generalized anxiety disorder).
Darvocet( analgesicfor mild to moderate pain).
antibioticfor respiratory and other infections).
*Evista (for the prevention and treatment of
osteoporosisand for the reduction in risk of invasive breast cancer).
*Forteo (for osteoporosis).
chemotherapyagent for lung, pancreatic and other cancers).
*Humalog (for diabetes).
Humatrope(a human growth hormonefor pediatric growth disorders).
*Strattera (non-stimulant ADHD medication).
Symbyax(for bipolar disorder)
*Xigris (for severe
schizophreniaand bipolar disorder).
A number of global leaders in the fields of health policy, management, and scientific research have worked at Lilly, including: [ [http://www.nndb.com/company/021/000051865/ Eli Lilly and Company Profile at NNDB.] ]
Ernesto Bustamante, Peruvian scientist.
Richard DiMarchi, Chief Scientific Officer, Marcadia Biotech.
Mitch Daniels, current governor of Indiana, former Hudson Instituteexecutive, and former director of Office of Management and Budgetfor President George W. Bush.
Roald Hoffmann, Nobel Prize-winning chemist.
*Michael Johns, former
White Housespeechwriter and Heritage Foundationpolicy analyst.
Claude H. Nash, CEO, ViroPharma.
*Peter Nicholas, co-founder of
Randall L. Tobias, former United States director of Foreign Assistance and administrator of the U.S. Agency for International Development(USAID), with the rank of ambassador.
Prominent Lilly board members have included:
George H. W. Bush, former President and Vice President of the United States of America.
Martin Feldstein, economist, Harvard University.
Kenneth Lay, former CEO, Enron.
William Verity Jr., former U.S. Secretary of Commerce.
In 2006, "Fortune" magazine named Eli Lilly and Company one of the top 100 companies in the United States for which to work. Also in 2006, "
Barron's Magazine" named the company among the top 500 best managed companies in the U.S. The company was named one of the top 10 best companies for working mothers in 2004 by "Working Mothers" magazine.
Eli Lilly has been involved in numerous controversies, including political and medical ethics controversies. For example, they withheld important information about the drug Zyprexa (Olanzapine).
In one of the only three cases to ever go to trial for SSRI indication in suicide, Eli Lilly was caught corrupting the judicial process by making a deal with the plaintiff's attorney to throw the case, in part by not disclosing damaging evidence to the jury. The case, known as the Fentress Case involved a Kentucky man, Joseph Wesbecker, on Prozac, who went to his workplace and opened fire killing 7 people, and injuring 12 others before turning the gun on himself. The jury returned a 9-to-3 verdict in favor of Lilly. The judge, in the end, took the matter to the Kentucky Supreme Court, which found that "there was a serious lack of candor with the trial court and there may have been deception, bad faith conduct, abuse of judicial process and, perhaps even fraud." The judge later revoked the verdict and instead, recorded the case as settled. The value of the secret settlement deal has never been disclosed, but was reportedly "tremendous".
June 2008, Eli Lilly and Co. agreed to settle a lawsuit stemming from discriminationcharges. The lawsuit alleged that the company withheld severancepay in order to convince former employee, Starr E. Johnson, to withdraw her lawsuit. Eli Lilly was accused by the U.S. Equal Employment Opportunity Commissionof violating the federal anti-discrimination law when they withheld severance benefits to Johnson. Johnson originally filed a discrimination charge after she was fired in 2005. She is a black woman and became disfigured in 1997when she was exposed to a blood pathogen. Her charge claimed that her supervisor stated that he was put in charge "so that he could watch her and get rid of her and that no one liked looking at her." Eli Lilly was ordered to pay $54,400 in severance pay, $7,000 in interest and compensatory damages along with $3,000 in attorneyfees. [cite web | url=http://www.chicagotribune.com/business/sns-ap-lilly-discrimination-settlement,0,1013548.story | title="Lilly agrees to settle discrimination lawsuit" | author=Murphy, Tom | publisher=Chicago Tribune | date=2008-06-30 | accessdate=2008-07-01]
Lilly Research Laboratories
* [http://www.lilly.com/ Eli Lilly and Company Official Web Site] .
* [http://www.nndb.com/company/021/000051865/ Eli Lilly and Company Profile at NNDB] .
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