IUPAC_name = "N"-Benzyl-"N"-methyl-prop-2-yn-1-amine

CAS_number = 555-57-7
ATC_prefix = C02
ATC_suffix = KC01
ATC_supplemental = ATC|C02|LL01
PubChem = 4688
DrugBank =
C = 11 | H = 13 | N = 1
molecular_weight = 159.23 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration =

Pargyline is a monoamine oxidase B (MAO-B) inhibitor. cite journal |author=Murphy DL, Karoum F, Pickar D, "et al" |title=Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline) |journal=J. Neural Transm. Suppl. |volume=52 |issue= |pages=39–48 |year=1998 |pmid=9564606 |doi= |url=]

It has antihypertensive effects.cite journal |author=Fuentes JA, Ordaz A, Neff NH |title=Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats |journal=Eur. J. Pharmacol. |volume=57 |issue=1 |pages=21–7 |year=1979 |month=July |pmid=477738 |doi= |url=]


It functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as blue cheese and beer, as this can lead to a hypertensive crisis. [Tulane University School of Medicine Department of Pharmacology: Autonomic Drug Profile handout, October 2006]


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  • pargyline — noun Etymology: propargyl, an alcohol + 2 ine Date: 1961 a monoamine oxidase inhibitor C11H13N that is used in the form of its hydrochloride especially as an antihypertensive agent …   New Collegiate Dictionary

  • pargyline — noun the monoamine oxidase inhibitor N benzyl N methyl prop 2 yn 1 amine …   Wiktionary

  • pargyline — par·gy·line pär jə .lēn n a monoamine oxidase inhibitor that is used in the form of its hydrochloride C11H13N·HCl esp. as an antihypertensive …   Medical dictionary

  • pargyline — par·gy·line …   English syllables

  • pargyline — ˈpärjəˌlēn noun Etymology: propargyl + ine (II) : a monoamine oxidase inhibitor C11H13N that is used in the form of its hydrochloride especially as an antihypertensive agent …   Useful english dictionary

  • pargyline hydrochloride — A nonhydrazine monoamine oxidase inhibitor, used as an antihypertensive agent …   Medical dictionary

  • Monoamine oxidase inhibitor — MAOI redirects here. For the Easter Island statues, see Moai. Monoamine oxidase Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating… …   Wikipedia

  • Selegiline — Systematic (IUPAC) name (R …   Wikipedia

  • Clorgiline — Systematic (IUPAC) name N [3 (2,4 dichlorophenoxy)propyl] N methyl prop 2 yn 1 amine Clinical data Pregnancy cat …   Wikipedia

  • Tranylcypromine — Systematic (IUPAC) name (±) trans 2 phenylcyclopropan 1 amine or (1R*,2S*) 2 phenylcyclopropan 1 amine …   Wikipedia

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