Neurocalcin


Neurocalcin
neurocalcin delta
Neurcalcin.png
Identifiers
Symbol NCALD
Entrez 83988
HUGO 7655
OMIM 606722
RefSeq NM_001040628
UniProt P61601
Other data
Locus Chr. 8 q22-q23

Neurocalcin is a neuronal calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins[1][2]. It expressed in mammalian brains. It possesses a Ca2+/myristoyl switch

The subclass of neurocalcins are brain-specific proteins that fit in to the EF-hand superfamily of calcium binding proteins. The NCS family were defined by the photoreceptor cell-specific protein, recoverin. Neurocalcin was purified from the bovine brain by using calcium-dependant drug affinity chromatography. The amino acid sequence showed that neurocalcin has three functional calcium binding sites. It is expressed in the central nervous system, retina, and adrenal gland. With this unique pattern of expression it is thought that neurcalcin offers a different physiological role than similar proteins visinin and recoverin.

External links

References

  1. ^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1887812. 
  2. ^ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879. 



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