Swiss-Prot


Swiss-Prot

Swiss-Prot is a manually curated biological database of protein sequences. Swiss-Prot was created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute.cite journal |author=Bairoch Amos|title= [http://bioinformatics.oupjournals.org/cgi/reprint/16/1/48 Serendipity in bioinformatics, the tribulations of a Swiss bioinformatician through exciting times!] |journal=Bioinformatics |volume=16 |pages=48–64 |year=2000 |pmid=10812477 |doi=10.1093/bioinformatics/16.1.48 — a historical account by Bairoch.] Swiss-Prot strives to provide reliable protein sequences associated with a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases.

In 2002, the UniProt consortium was created: it is a collaboration between the Swiss Institute of Bioinformatics, the European Bioinfomatics Institute and the Protein Information Resource (PIR), funded by the National Institutes of Health. Swiss-Prot and its automatically curated supplement TrEMBL, have joined with the Protein Information Resource protein database to produce the UniProt Knowledgebase, the world's most comprehensive catalogue of information on proteins. [Wu, C.H. "et al." (January 2006) "The Universal Protein Resource (UniProt): an expanding universe of protein information.". "Nucleic Acids Research", 1;34 (Database issue): D187–91.] As of 3 April, 2007, UniProtKB/Swiss-Prot release 52.2 contains 263,525 entries. As of 3 April, 2007, the UniProtKB/TrEMBL release 35.2 contains 4,232,122 entries.

The UniProt consortium produced 3 database components, each optimised for different uses. The UniProt Knowledgebase (UniProtKB (Swiss-Prot + TrEMBL)), the UniProt Non-redundant Reference (UniRef) databases, which combine closely related sequences into a single record to speed similarity searches and the UniProt Archive (UniParc), which is a comprehensive repository of protein sequences, reflecting the history of all protein sequences.

References

* Séverine Altairac, " [http://expasy.org/prolune/dossiers/prolune018.shtml Naissance d’une banque de données: Interview du prof. Amos Bairoch] ". " [http://expasy.org/prolune/ Protéines à la Une] ", August 2006. ISSN 1660-9824.

External links

* [http://www.expasy.org/sprot/ Swiss-Prot Protein Database] (Swiss Institute of Bioinformatics)
* [http://www.uniprot.org/ UniProt] (Swiss Institute of Bioinformatics)


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