Hemosuccus pancreaticus, also known as pseudohematobilia or Wirsungorrhage is a rare cause of hemorrhage in the
gastrointestinal tract. It is caused by a bleeding source in the pancreas, pancreatic duct, or structures adjacent to the pancreas, such as the splenic artery, that bleed into the pancreatic duct, which is connected with the bowel at the duodenum, the first part of the small intestine. Patients with hemosuccus may develop symptoms of gastrointestinal hemorrhage, such as blood in the stools, maroon stools, or melena, which is a dark, tarry stool caused by digestion of red blood cells. They may also develop abdominal pain. It is associated with pancreatitis, pancreatic cancerand aneurysms of the splenic artery. Hemosuccus may be identified with esophagogastroduodenoscopy, where fresh blood may be seen from the pancreatic duct. Alternatively, angiographymay be used to inject the celiac axisto determine the blood vessel that is bleeding. This may also be used to treat hemosuccus, as embolizationof the end vessel may terminate the hemorrhage. However, a distal pancreatectomy -- surgery to removal of the tail of the pancreas -- may be required to stop the hemorrhage.
Hemosuccus pancreaticus is a rare entity, and, as a result, determining the rate of symptoms is based on small case series. cite journal | author = Clay R, Farnell M, Lancaster J, Weiland L, Gostout C | title = Hemosuccus pancreaticus. An unusual cause of upper gastrointestinal bleeding. | journal = Ann Surg | volume = 202 | issue = 1 | pages = 75–9 | year = 1985 | pmid = 3874611 | doi = 10.1097/00000658-198507000-00012] cite journal | author = Risti B, Marincek B, Jost R, Decurtins M, Ammann R | title = Hemosuccus pancreaticus as a source of obscure upper gastrointestinal bleeding: three cases and literature review. | journal = Am J Gastroenterol | volume = 90 | issue = 10 | pages = 1878–80 | year = 1995 | pmid = 7572914] The diagnosis may be overlooked fairly easily as a result. cite journal | author = Julianov A, Rachkov I, Karashmalakov A | title = Hemosuccus pancreaticus. | journal = Surgery | volume = 133 | issue = 1 | pages = 114–5 | year = 2003 | pmid = 12563247 | doi = 10.1067/msy.2003.90] The usual presentation of hemosuccus is the development of symptoms of upper or
lower gastrointestinal bleeding, such as melena(or dark, black tarry stools), maroon stools, or hematochezia, which is frank rectal bleeding. The source of hemorrhage is usually not determined by standard endoscopic techniques, and the symptoms of the condition are usually grouped as a cause of obscure overt gastrointestinal hemorrhage. Over one-half of patients with hemosuccus also develop abdominal pain, usually located in the epigastrium, or uppermost part of the abdomen. The pain is described as being "crescendo-decrescendo" in nature, meaning that it increases and decreases in intensity slowly with time. This is thought to be due to transient blockage of the pancreatic ductfrom the source of bleeding, or from clots. If the source of the bleeding also involves obstruction of the common bile duct(such as with some tumours of the head of the pancreas), the patient may develop jaundice, or "silver stools", an uncommon finding of acholic stools mixed with blood. [cite journal | author = Ong Y, Pintauro W | title = Silver stools. | journal = JAMA | volume = 242 | issue = 22 | pages = 2433 | year = 1979 | pmid = 490859 | doi = 10.1001/jama.242.22.2433]
Testing and diagnosis
The diagnosis of hemosuccus pancreaticus can be difficult to make. Most patients who develop bleeding in the gastrointestinal tract have endoscopic procedures done to visualize the bowel in order to find and treat the source of the bleeding. With hemosuccus, the bleeding is coming from the
pancreatic ductwhich enters into the first part of the small intestine, termed the duodenum. Typical gastroscopes used to visualize the esophagus, stomach and duodenum are designed with fiber-optic illumination that is directed in the same direction as the endoscope, meaning that visualization is in the forward direction. However, the pancreatic duct orifice is located on the side of the duodenum, meaning that it can be missed on forward-viewing endoscopy. A side-viewing endoscope (known as a "duodenoscope", or "side-viewer") used for endoscopic retrograde cholangiopancreatography(ERCP), a procedure to visualize the bile ducts and pancreatic ducton fluoroscopy, can be used to localize the bleeding to the pancreatic duct. cite journal | author = Adler D, Petersen B, Gostout C | title = Hemosuccus pancreaticus. | journal = Gastrointest Endosc | volume = 59 | issue = 6 | pages = 695 | year = 2004 | pmid = 15114316 | doi = 10.1016/S0016-5107(04)00164-6] [cite journal | author = Rösch W, Schaffner O, Frühmorgen P, Koch H | title = Massive gastrointestinal hemorrhage into the pancreatic duct - diagnosed by duodenoscopy and ERCP. | journal = Endoscopy | volume = 8 | issue = 2 | pages = 93–6 | year = 1977 | pmid = 301087] It can be confused with bleeding from the common bile duct on endoscopy, leading to the term "pseudohematobilia".
Once the bleeding has been localized to the pancreatic duct,
angiography, or the injection of dye into the celiac artery, which supplies the pancreas, can be performed to determine which vessel is the cause of the bleeding. This is additionally useful to treatment, as the bleeding vessel can be occluded (termed "embolization") at the time of angiography.cite journal | author = Etienne S, Pessaux P, Tuech J, Lada P, Lermite E, Brehant O, Arnaud J | title = Hemosuccus pancreaticus: a rare cause of gastrointestinal bleeding. | journal = Gastroenterol Clin Biol | volume = 29 | issue = 3 | pages = 237–42 | year = 2005 | pmid = 15864172 | doi = 10.1016/S0399-8320(05)80755-9]
The causes of hemosuccus pancreaticus can be grouped into diseases of the pancreas and diseases of the vascular structures around the pancreas. Diseases of the pancreas include acute and
chronic pancreatitis, [cite journal | author = Kuganeswaran E, Smith O, Goldman M, Clarkston W | title = Hemosuccus pancreaticus: rare complication of chronic pancreatitis. | journal = Gastrointest Endosc | volume = 51 | issue = 4 Pt 1 | pages = 464–5 | year = 2000 | pmid = 10744821] pancreatic cancer, pancreatic duct stones, [cite journal | author = Lacey S, Chak A | title = Hemosuccus pancreaticus: dorsal pancreatic duct stone and gastroduodenal artery pseudoaneurysm. | journal = Gastrointest Endosc | volume = 54 | issue = 3 | pages = 363 | year = 2001 | pmid = 11522982 | doi = 10.1067/mge.2001.116901] ruptured aneurysms of the splenic artery, and pseudoaneurysms of the splenic artery [cite journal | author = Cahow C, Gusberg R, Gottlieb L | title = Gastrointestinal hemorrhage from pseudoaneurysms in pancreatic pseudocysts. | journal = Am J Surg | volume = 145 | issue = 4 | pages = 534–41 | year = 1983 | pmid = 6601464 | doi = 10.1016/0002-9610(83)90054-5] and hepatic artery. [cite journal | author = Fernandez-Cruz L, Pera M, Vilella A, Llovera J, Navasa M, Teres J | title = Hemosuccus pancreaticus from a pseudoaneurysm of the hepatic artery proper in a patient with a pancreatic pseudocyst. | journal = Hepatogastroenterology | volume = 39 | issue = 2 | pages = 149–51 | year = 1992 | pmid = 1634182] Pseudoaneurysms are complications of pancreatitiswhere a pseudocystis formed, with one wall abutting an artery, usually the splenic artery. Should the arterial wall rupture, the pseudoaneurysm will hemorrhage into the pancreatic duct.
Rarely the bleeding is not channeled into the bowel from the
main pancreatic duct(or "duct of Wirsung"), but rather comes from the accessory pancreatic duct(or "duct of Santorini"). The former is termed "Wirsungorrhage" and the latter is termed "Santorinirrhage". Bleeding from the duct of Santorini can be caused by pancreas divisum, a possible congenital cause of pancreatitis. [cite journal | author = Vázquez-Iglesias J, Durana J, Yañez J, Rodriguez H, Garcia-Vallejo L, Arnal F | title = Santorinirrhage: hemosuccus pancreaticus in pancreas divisum. | journal = Am J Gastroenterol | volume = 83 | issue = 8 | pages = 876–8 | year = 1988 | pmid = 3260745]
Treatment of hemosuccus pancreaticus depends on the source of the hemorrhage. If the bleeding is identified on
angiographyto be coming from a vessel that is small enough to occlude, embolization through angiography may stop the bleeding. Both coils in the end-artery and stents across the area of bleeding have been used to control the hemorrhage. [cite journal | author = Benz C, Jakob P, Jakobs R, Riemann J | title = Hemosuccus pancreaticus--a rare cause of gastrointestinal bleeding: diagnosis and interventional radiological therapy. | journal = Endoscopy | volume = 32 | issue = 5 | pages = 428–31 | year = 2000 | pmid = 10817187 | doi = 10.1055/s-2000-638] However, the bleeding may be refractory to the embolization, which would necessitate surgery to remove the pancreas at the source of hemorrhage. Also, the cause of bleeding may be too diffuse to be treated with embolization (such as with pancreatitis or with pancreatic cancer). This may also require surgical therapy, and usually a distal pancreatectomy, or removal of the part of the pancreas from the area of bleeding to the tail, is required.
Hemosuccus pancreaticus was first described as a cause of hemorrhage by Lower and Farrell, who described an aneurysm of the splenic artery causing bleeding through the pancreatic duct. [cite journal | author = Lower WE, Farrell JI | title = Aneurysm of the splenic artery: report of a case and review of the literature | journal = Arch. Surg. | volume = 23 | pages = 182–90 | year = 1931]
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