Immune-mediated inflammatory diseases
Immune Mediated inflammatory Disease (IMID) is any of a group of conditions or diseases that lack a definitive
etiology, but which are characterized by common inflammatory pathways leading to inflammation, and which may result from, or be triggered by, a dysregulationof the normal immune response. All IMIDs can cause end organ damage, and are associated with increased morbidityand/or mortality.
Inflammation is an important and growing area of
biomedicalresearch and health carebecause inflammation mediates and is the primary driver of many medical disorders and autoimmune diseases, including ankylosing spondylitis, psoriasis, psoriatic arthritis, Behcet's disease, arthritis, inflammatory bowel disease(IBD), autistic enterocolitis, and allergy, as well as many cardiovascular, neuromuscular, and infectious diseases. Some current research even suggests that agingis a consequence, in part, of inflammatory processes.
IMID is characterized by
immune disregulation, and one underlying manifestation of this immune disregulation is the inappropriate activation of inflammatory cytokines, such as IL-12, IL-6or TNF alpha, whose actions lead to pathologicalconsequences.
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