Thiethylperazine

Thiethylperazine
Systematic (IUPAC) name
2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat.  ?
Legal status  ?
Pharmacokinetic data
Protein binding 60%
Identifiers
CAS number 1420-55-9 YesY
ATC code R06AD03
PubChem CID 5440
DrugBank APRD00323
ChemSpider 5245 YesY
UNII 8ETK1WAF6R YesY
KEGG D02354 YesY
ChEBI CHEBI:9544 N
ChEMBL CHEMBL1378 YesY
Chemical data
Formula C22H29N3S2 
Mol. mass 399.618 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Thiethylperazine (Torecan) is an antiemetic of the phenothiazine class. Though it was never licensed or used as an antipsychotic, it may have such effects.

Thiethylperazine.png

Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice. [1]

References

  1. ^ Science Daily (September 1, 2011). "Alzheimer Disease: Transport Protein ABCC1 Plays Key Role in Clearing Beta-Amyloid from Brains of Mice.". http://www.sciencedaily.com/releases/2011/09/110901134628.htm. Retrieved September 1, 2011. 

Bourquin, J. P.; Schwarb, G.; Gamboni, G.; Rischer, R.; Ruesch, L.; Uldimann, S. G.; Theuss, U.; Schenke, E.; Renz, J.; Helv. Chim. Acta 1958, 41, 1072.