IUPAC_name = 2- [4-(benzo [1,3] dioxol-5-ylmethyl)piperazin-1-yl] pyrimidine

CAS_number = 3605-01-4
ATC_prefix = N04
ATC_suffix = BC08
PubChem = 4850
DrugBank =
C = 16 | H = 18 | N = 4 | O = 2
molecular_weight = 298.340 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life = 1.7 – 6.9 hours
excretion = Renal (68%) and biliary (25%)
pregnancy_AU =
pregnancy_US =
pregnancy_category =
legal_AU =
legal_UK =
legal_US =
legal_status =
routes_of_administration = Oral

Piribedil is a piperazine dopamine agonist; and marketed as TRIVASTAL Retard 50.

Trivastal retard 50 is also distributed as: "Trastal", "Trivastal 50 retard", "Trivastal 50mg LP", "Trivastan ritardo" and "Pronoran".


Piribedil 50 mg per tablet - sustained-release.


*Treatment of Parkinson's disease, either as monotherapy (without L-dopa) or in combination with L-dopa therapy, in the early stages as well as in the advanced stages.
*Treatment of pathological cognitive deficits in the elderly (impaired attention, memory, etc). Treatment of dizziness in the elderly.
*Treatment of retinal ischemic manifestations.
*Adjuvant treatment in intermittent claudication due to peripheral occlusive arterial disease of the lower limbs (stage 2).
*Anhedonia and treatment-resistant depression in unipolar and bipolar depressives (off label).


Parkinson's disease

Administration of piribedil should be initiated with one tablet daily during the first week. Dosage should then be gradually increased every week until achieving the optimal therapeutic dose:
*as monotherapy: three to five tablets in three to five doses daily.
*in combination with L-dopa therapy: one to three tablets daily.

Other indications

One tablet daily at the end of the main meal. In severe cases: two tablets daily in two doses.

Adverse effects

*Minor gastrointestinal disorders (nausea, vomiting, flatulence) in predisposed individuals, or when taken between meals: Adjust dosage individually, and/or add domperidone.
*Orthostatic hypotension or drowsiness may occur, particularly in predisposed individuals (underlying condition or causative illness).


Dopamine antagonists reduce the effect of piribedil.


At very high doses, piribedil has an emetic action on the chemoreceptor trigger zone. Tablets will thus be rapidly rejected, which explains why no data are currently available concerning the risk of overdosage.

Receptor affinities

*Dopamine receptor agonist, selective for subtypes D2 and D3.
*Adrenergic receptor antagonist, subtypes α2a and α2c: could be the reason why piribedil seems to cause less drowsiness than other dopamine agonists.cite news|title=Piribedil|last=Schubert-Zsilavecz|first=M|work=Neue Arzneimittel 2008|language=German|]
*Lack of affinity to serotonin receptor 5-HT2B: theoretically no risk of heart valve impairment.


External links

* [http://www.trivastal.com Official site]

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Piribedil — Strukturformel Allgemeines Freiname Piribedil Andere Namen …   Deutsch Wikipedia

  • piribedil — An agent that stimulates dopamine receptors in the brain and also exerts a peripheral vasodilator effect …   Medical dictionary

  • Benzylpiperazine — Systematic (IUPAC) name 1 benzylpiperazine …   Wikipedia

  • Methylenedioxybenzylpiperazine — Systematic (IUPAC) name 1 (benzo[1,3]dioxol 5 ylmethyl)piperazine …   Wikipedia

  • para-Methoxyphenylpiperazine — Systematic (IUPAC) name 1 (4 methoxyphenyl)piperazine …   Wikipedia

  • Clozapine — Not to be confused with clonazepam or Klonopin. Clozapine Systematic (IUPAC) name …   Wikipedia

  • Trifluoperazine — Systematic (IUPAC) name 10 [3 (4 methylpiperazin 1 yl)propyl] 2 (trifluoromethyl) 10H phenothiazine Clinical data AHFS/ …   Wikipedia

  • Aripiprazole — Systematic (IUPAC) name 7 {4 [4 (2,3 dichlorophenyl)piperazin 1 yl]butoxy} 3,4 dihydroquinolin 2(1H) one Clinical data Trade names …   Wikipedia

  • Loxapine — Systematic (IUPAC) name 2 Chloro 11 (4 methylpiperazin 1 yl)dibenzo[b,f][1,4]oxazepine Clinical data AHFS/Drugs.com …   Wikipedia

  • Hydroxyzine — Systematic (IUPAC) name (±) 2 (2 {4 [(4 chlorophenyl) phe …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.