IUPAC_name = 6- [amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl] -4-(3-chlorophenyl)-1-methylquinolin-2-one
PubChem = 148193
C=27 | H=22 | Cl=2 | N=4 | O=1
molecular_weight = 489.395 g/mol
Tipifarnib (Zarnestra) is a drug that is being investigated in patients 65 years of age and older with newly diagnosed
acute myeloid leukemia(AML).
The compound was discovered by and is under investigation by
Johnson & Johnson Pharmaceutical Research & Development, L.L.C, with registration number R115777.
Tipifarnib was submitted to the FDA by
Johnson & Johnsonfor the treatment of AML in patients aged 65 and over with a New Drug Application (NDA) to the Food and Drug Administration (FDA) on January 24, 2005.
In June of 2005, the FDA issued a "not approvable" letter for tipifarnib. [ [http://www.drugs.com/nda/r115777_050630.html R115777 New Drug Application ] ]
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