ImageFile=Pantothenic acid structure.svg
IUPACName=3- [(2,4-dihydroxy-3, 3-dimethyl-1-oxobutyl) amino] propanoic acid
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Section2= Chembox Properties
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Pantothenic acid, also called
vitaminB5 (a B vitamin), is a water- solublevitamin required to sustain life ( essential nutrient). Pantothenic acid is needed to form coenzyme-A(CoA), and is critical in the metabolism and synthesis of carbohydrates, proteins, and fats. In chemical structure, it is the amide between D-pantoate and beta-alanine. Its name is derived from the Greek "pantothen" (polytonic|παντόθεν) meaning "from everywhere" and small quantities of pantothenic acid are found in nearly every food, with high amounts in whole-grain cereals, legumes, eggs, meat, and royal jelly. It is commonly found as its alcohol analog, the provitamin panthenol, and as calcium pantothenate.
Only the dextrorotatory (D) isomer of pantothenic acid possesses biologic activity.MedlinePlus. "Pantothenic acid (Vitamin-B5), Dexpanthenol". Natural Standard Research Collaboration. U.S. National Library of Medicine. Last accessed 4 Jan 2007. [http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-vitaminb5.html] ] The levorotatory (L) form may antagonize the effects of the dextrorotatory isomer. [Kimura S, Furukawa Y, Wakasugi J, Ishihara Y, Nakayama A. Antagonism of L(-)pantothenic acid on lipid metabolism in animals.J Nutr Sci Vitaminol (Tokyo). 1980;26(2):113-7. PMID 7400861.]
Pantothenic acid is used in the synthesis of
coenzyme A(CoA). Coenzyme A may act as an acylgroup carrier to form acetyl-CoAand other related compounds; this is a way to transport carbonatoms within the cell. The transfer of carbon atoms by coenzyme A is important in cellular respiration, as well as the biosynthesis of many important compounds such as fatty acids, cholesterol, and acetylcholine.
Acetyl-CoA is used in the condensation of oxaloacetate to citrate at the initiation of the
TCA cycle. From the TCA cycle, acetyl-CoA can also initiate the fatty acidsynthesis pathway [Combs, G.F. The Vitamins: Fundamental Aspects in Nutrition and Health. 2008.San Diego: Elsevier Inc.]
Since pantothenic acid participates in a wide array of key biological roles, it is considered essential to all forms of life.pauling|id=vitamins/pa|title=Pantothenic Acid|author=Jane Higdon] As such, deficiencies in pantothenic acid may have numerous wide-ranging effects, as discussed below.
Pantothenic acid is vital for a healthy pregnancy.
Small quantities of pantothenic acid are found in most foods. [cite web |url=http://www.ars.usda.gov/Services/docs.htm?docid=9673 |title=Nutrient Data Products and Services, Nutrient Data : Reports by Single Nutrients |accessdate=2007-08-12 |format= |work=] The major food sources of pantothenic acid are meats. Some vegetables are also good sources, as well as whole grains, but a large amount of pantothenic acid is found in the outer layers of the whole grains, so the milling process removes a majority of the vitamin. In animal feeds, the most important sources of the vitamin are rice, wheat brans, alfalfa, peanut meal, molasses, yeasts, and condensed fish solutions. The most significant source of pantothenic acid in nature are coldwater fish ovaries and royal jelly. [ Combs,G. F. Jr. "The vitamins: Fundamental Aspects in Nutrition and Health". 3rd Edition. Ithaca, NY: Elsevier Academic Press; 2008; pg.346]
A recent study also suggests that gut bacteria in humans can generate pantothenic acid. [cite journal | author=Said H, Ortiz A, McCloud E, Dyer D, Moyer M, Rubin S | title=Biotin uptake by human colonic epithelial NCM460 cells: a carrier-mediated process shared with pantothenic acid. | journal=Am J Physiol | volume=275 | issue=5 Pt 1 | pages=C1365–71 | year=1998 | pmid=9814986]
The derivative of pantothenic acid, pantothenol, is a more stable form of the vitamin and is often used as a source of the vitamin in multivitamin supplements. [ Combs,G. F. Jr. "The vitamins: Fundamental Aspects in Nutrition and Health". 3rd Edition. Ithaca, NY: Elsevier Academic Press; 2008; pg.347] Another common supplemental form of the vitamin is calcium pantothenate. Calcium pantothenate is often used in dietary supplements because as a salt, it is more stable than pantothenic acid in the digestive tract allowing for better absorption.
Possible benefits of supplementation: Doses of 500-1200mg/day of pantothine has been shown to reduce total serum cholesteron, LDL-cholesterol, and triglycerides, and it may increase HDL-cholesterol. Doses of 2g/day of calcium pantothenate may reduce the duration of morning stiffness, degree of disability, and pain severity in rheumatoid arthritis patients. Although the results are inconsistent, supplementation may improve oxygen utilization efficiency and reduce lactic acid accumulation in athletes. [Combs, Gerald. The Vitamins: Fundamental Aspects in Nutrition and Health. Burlington: Elsevier Academic Press, 2008.]
Pantothenate in the form of
pantethineis considered to be the more active form of the vitamin in the body, but is unstable at high temperatures or when stored for long periods, so calcium pantothenate is the more usual form of vitamin B5 when it is sold as a dietary supplement. Ten mg of calcium pantothenate is equivalent to 9.2 mg of pantothenic acid.
*United Kingdom RDA: 6 mg/day
Within most foods, pantothenic acid is in the form of CoA or acyl-carrier protein (ACP). In order for the intestinal cells to absorb this vitamin it must be converted into free pantothenic acid. Within the lumen of the intestine, CoA and ACP are degraded from the food into 4'-phosphopantetheine. This form is then dephosphorylated into pantetheine that is then acted upon by the intestinal enzyme, pantetheinase, to yield free pantothenic acid.
Free pantothenic acid is absorbed into intestinal cells via a saturable, sodium-dependent active transport system. At high levels of intake, when this mechanism is saturated, some pantothenic acid may also be absorbed via passive diffusion. [Combs GF. The vitamins: fundamental aspects in nutrition and health. 3rd ed. Boston: Elsevier, 2008.]
Pantothenic acid deficiency is exceptionally rare and has not been thoroughly studied. In the few cases where deficiency has been seen (victims of starvation and limited volunteer trials), nearly all symptoms can be reversed with the return of pantothenic acid.
Symptoms of deficiency are similar to other
vitamin Bdeficiencies. Most are minor, including fatigue, allergies, nausea, and abdominal pain. In a few rare circumstances more serious (but reversible) conditions have been seen, such as adrenalinsufficiency and hepatic encephalopathy.
It has been noted that painful burning sensations of the feet were reported in tests conducted on volunteers. Deficiency of pantothenic acid may explain similar sensations reported in malnourished prisoners of war.
Deficiency symptoms in other non-ruminant animals include disorders of the nervous, gastrointestinal, and immune systems, reduced growth rate, decreased food intake, skin lesions and changes in hair coat, alterations in lipid and carbohydrate metabolism. [Smith, C. M. and W. O. Song. 1996. Comparative nutrition of pantothenic acid. Nutr. Biochem. 7:312-321.]
Toxicity of pantothenic acid is unlikely. Large doses of the vitamin, when ingested, have no reported side effects and massive doses (e.g. 10 g/day) may only yield mild intestinal distress and diarrhea at worst. There are also no adverse reactions known following parenteral or topical application of the vitamin. [ Combs, G. F. Jr. "The Vitamins: Fundamental Aspects in Nutrition and Health". 2nd Edition. Ithaca, NY: Elsevier Academic Press; 1998; pg.374]
Given pantothenic acid's prevalence among living things and the limited body of studies in deficiency, many "alternative" uses of pantothenic acid have been devised.
Mouse models identified skin irritation and loss of hair color as possible results of severe pantothenic acid deficiency.Fact|date=August 2007 As a result, the cosmetic industry began adding pantothenic acid to various cosmetic products, including shampoo. These products, however, showed no benefits in human trials.Fact|date=August 2007 Despite this, many cosmetic products still advertise pantothenic acid additives.
Following from discoveries in mouse trials,Fact|date=February 2007 in the late 1990s a small study was published promoting the use of pantothenic acid to treat
According to a study published in 1995 by Dr. Lit-Hung Leung, [cite journal |author=Leung L |title=Pantothenic acid deficiency as the pathogenesis of acne vulgaris |journal=Med Hypotheses |volume=44 |issue=6 |pages=490–2 |year=1995 |pmid=7476595 | doi = 10.1016/0306-9877(95)90512-X ] high doses of Vitamin B5 resolved acne and decreased pore size. Dr. Leung also proposes a mechanism, stating that CoA regulates both hormones and fatty-acids, and without sufficient quantities of pantothenic acid, CoA will preferentially produce
androgens. This causes fatty acids to build up and be excreted through sebaceous glands, causing acne. Leung's study gave 45 Asian males and 55 Asian females varying doses of 10-20g of pantothenic acid (100,000%-200,000% of the US Daily Value), 80% orally and 20% through topical cream.Leung noted improvement of acne within one week to one month of the start of the treatment.Fact|date=February 2007
Critics are quick to point out the flaws in Dr. Leung's study, however. Dr. Leung's study was not a double-blind placebo controlled trial. To date, the onlystudy looking at the effect of Vitamin B5 on acne is Dr. Leung's, and few if any dermatologists prescribe high-dose pantothenic acid.Furthermore, there is no evidence documenting acetyl-CoA regulation of
androgensinstead of fatty acidsin times of stress or limited availability, sincefatty acids are also necessary for life.
Diabetic peripheral polyneuropathy
28 out of 33 patients (84,8%) previously treated with alpha-lipoic acid for peripheral
polyneuropathyreported further improvement after combination with pantothenic acid. The theoretical basis for this is that both substances intervene at different sites in pyruvate metabolism and are thus more effective than one substance alone. Additional clinical findings indicated that diabetic neuropathy may occur in association with a latent prediabetic metabolic disturbance, and that the symptoms of neuropathy can be favourably influenced by the described combination therapy, even in poorly controlled diabetes. [Münchener Medizinische Wochenschrift (Germany), 1997, 139/12 (34-37)]
Taken before bedtime can increase the likeliness of having/remembering dreams with elevated vividness.
No dietary requirement for pantothenic acid has been established as synthesis of pantothenic acid by ruminal microorganisms appears to be 20 to 30 times more than dietary amounts. Net microbial synthesis of pantothenic acid in the rumen of steer calves has been estimated to be 2.2 mg/kg of digestible organic matter consumed per day. The degradation of dietary intake of pantothenic acid is considered to be 78 percent. Supplementation of pantothenic acid at 5 to 10 times theoretic requirements did not improve performance of feedlot cattle [National Research Council. 2001. Nutrient Requirements of Dairy Cattle. 7th rev. ed. Natl. Acad. Sci., Washington, DC.]
* Vitamin B5
* [http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/pan_0196.shtml PDRhealth.com] - Pantothenic acid
* [http://www.biocheminfo.org/klotho/html/R-pantothenate.html Pantothenate] at Klotho
* [http://www.coenzyme-a.com/acne_vulgaris.html Reference] link to Coenzyme-A and acne
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Look at other dictionaries:
Pantothenic acid — is vitamin B5, one of the less well known B vitamins, perhaps because it is widely distributed in nature. Pantothenic acid is virtually ubiquitous. It is present in foods as diverse as poultry, soybeans, yogurt, and sweet potatoes. No naturally… … Medical dictionary
pantothenic acid — pantothenic acid. См. витамин В5. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) … Молекулярная биология и генетика. Толковый словарь.
pantothenic acid — [pan΄tō then′ik] n. [Gr pantothen, from every side < pantos (see PANTO ) + IC] a yellow, viscous oil, C9H17NO5, a member of the vitamin B complex, widely distributed in animal and plant tissues and prepared synthetically: thought to be… … English World dictionary
pantothenic acid — /pan teuh then ik, pan /, Biochem. a hydroxy acid, C9H17O5N, found in plant and animal tissues, rice, bran, etc., that is part of the B complex of vitamins and is essential for cell growth. [1930 35; < Gk pántothen from all quarters (panto PANTO… … Universalium
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pantothenic acid — noun Etymology: Greek pantothen from all sides, from pant , pas all more at pan Date: 1933 a viscous oily acid C9H17NO5 of the vitamin B complex found in all living tissues … New Collegiate Dictionary
pantothenic acid — pan′to•then′ic ac′id [[t]ˈpæn təˈθɛn ɪk, ˌpæn [/t]] n. biochem. nut a hydroxy acid, C9H17O5N, that is a component of the vitamin B complex, abundant in liver, yeast, and bran • Etymology: 1930–35; < Gk pántothen from all quarters (panto panto… … From formal English to slang
pantothenic acid — /ˌpæntəθɛnɪk ˈæsəd/ (say .pantuhthenik asuhd) noun an oily hydroxy acid, HOCH2C(CH)2CHOHCONHCH2CH2COOH, found in plant and animal tissues, rice, bran, etc., which is essential for cell growth, and is a constituent of coenzyme A … Australian English dictionary
pantothenic acid — a B vitamin essential in the diet of many cultured species … Dictionary of ichthyology