Pravastatin

Pravastatin
Systematic (IUPAC) name
(3R,5R)-3,5-dihydroxy-7-((1R,2S,6S,8R,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-heptanoic acid
Clinical data
Trade names Pravachol
AHFS/Drugs.com monograph
MedlinePlus a692025
Pregnancy cat. X
Legal status  ?
Routes oral
Pharmacokinetic data
Bioavailability 17%
Protein binding 50%
Metabolism renal and hepatic
Half-life 1.5-2 hours
Identifiers
CAS number 81093-37-0 YesY
ATC code C10AA03
PubChem CID 54687
DrugBank APRD00328
ChemSpider 49398 YesY
UNII KXO2KT9N0G YesY
ChEMBL CHEMBL1144 YesY
Chemical data
Formula C23H36O7 
Mol. mass 424.528 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Pravastatin (marketed as Pravachol or Selektine) is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease. Initially known as CS-514, it was originally identified in a bacterium called Nocardia autotrophica by researchers of the Sankyo Pharma Inc..[1] It is presently being marketed outside Japan by the pharmaceutical company Bristol-Myers Squibb.

The U.S. Food and Drug Administration approved generic pravastatin for sale in the United States for the first time on April 24, 2006. Generic pravastatin sodium tablets are manufactured by TEVA Pharmaceuticals in Kfar Sava, Israel.[2]

Health effects

The primary uses of prevastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease.[3] It is recommended to be used only after other measures such as diet, exercise, and weight reduction have not improved cholesterol levels.[3]

References

  1. ^ Yoshino G, Kazumi T, Kasama T, et al. (1986). "Effect of CS-514, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on lipoprotein and apolipoprotein in plasma of hypercholesterolemic diabetics". Diabetes Res. Clin. Pract. 2 (3): 179–81. doi:10.1016/S0168-8227(86)80020-1. PMID 3091343. 
  2. ^ "FDA Approves First Generic Pravastatin". http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2006/ucm108644.htm. Retrieved 2008-01-20. 
  3. ^ a b "Prevachol". The American Society of Health-System Pharmacists. http://www.drugs.com/monograph/pravachol.html. Retrieved 3 April 2011. 

External links