V. Craig Jordan
V. Craig Jordan Born New Braunfels, Texas, US Residence UK, US Fields Pharmacology, Cancer Research Institutions University of Leeds; Ludwig Institute, Bern, Switzerland; University of Wisconsin–Madison; Northwestern University; Fox Chase Cancer Center; Georgetown University Alma mater University of Leeds Known for "Father of Tamoxifen"; Research on SERMs, particularly tamoxifen and raloxifene Notable awards Kettering Prize; American Cancer Society Medal of Honor; American Society of Clinical Oncology 38th David A. Karnofsky Award and Lecture; Honorary Fellow Royal Society of Medicine (UK); Fellow Academy of Medical Sciences (UK); Elected Member National Academy of Sciences (US); St. Gallen Prize (Switzerland)
Virgil Craig Jordan, OBE (born Texas, US, British/American joint national) is a scientist specializing in drugs for breast cancer treatment and prevention. Currently Scientific Director and Vice Chairman of Oncology at the Lombardi Comprehensive Cancer Center of Georgetown University, Jordan was the first to discover the breast cancer prevention properties of tamoxifen and the scientific principles for adjuvant therapy with antihormones. More recently his work has branched out into the prevention of multiple diseases in women with the discovery of the drug group, selective estrogen receptor modulator (SERMs).
A highly regarded researcher, his paper The Effect of Raloxifene on Risk of Breast Cancer in Postmenopausal Women - Results from the more Randomized Trial was one of the top 20 most cited papers in breast cancer research during 2003 and 2004.
Born in New Braunfels, Texas, US, Jordan moved to England with his family as a child. He went to school at Moseley Hall Grammar School in Cheshire before attending the University of Leeds where he received BSc, PhD and DSc degrees in Pharmacology.
Jordan began working on the structure-activity of anti-estrogens as part of his PhD at Leeds University. During that time he met Arthur Walpole the patent holder for the drug that became tamoxifen.
In September 1972 Jordan became a Visiting Scientist at the Worcester Foundation for Experimental Biology, Massachusetts. While there he began researching the idea that tamoxifen, a selective estrogen receptor modulator (SERM), could block estrogen receptors in breast tumors. Estrogen receptors in breast tumors attract estrogen which is then absorbed into the cancerous cell and encourages the cell to divide, causing the cancer to grow. Until this time, the treatment for this type of breast cancer was oophorectomy.
In 1980 Jordan joined the University of Wisconsin–Madison where he started to look at the effects of tamoxifen and another SERM, raloxifene, on bone density and coronary systems. This was needed because of the concern that long term use of SERMs could lead to osteoporosis and heart disease. Jordan's research showed that post-menopausal women who took these drugs did not suffer from a lowering of bone density or an increase in blood cholesterol. Raloxifene is now used in the prevention of osteoporosis. Jordan gained full Professorship at Wisconsin in 1985, the same year his alma mater awarded him a DSc.
In 1993 Jordan became Professor of Cancer Pharmacology at Northwestern University Medical School in Chicago, IL., and director of the Breast Cancer Research Program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. He was the inaugural holder of the Diana Princess of Wales Professor of Cancer Research (1999–2004).
In January 2005, Jordan was the inaugural Alfred G. Knudson Chair of Cancer Research at the Fox Chase Cancer Center in Philadelphia, PA. He has recently published work showing that estrogen, given at the right time, causes the destruction of cancer cells rather than feeding their growth. Currently, Jordan is the Scientific Director of the Lombardi Comprehensive Cancer Center, Professor of Oncology and Pharmacology, Vice Chair of the Department of Oncology, and the Vincent T. Lombardi Chair of Translational Cancer Research, Georgetown University, Washington, D.C.
Personal Life and National Service
Jordan is the father of two daughters, Helen Melissa Yvonne Turner and Alexandra Katherine Louise Noel. Military Service: Captain Intelligence Corps (V) (Staff Deputy Chief Scientist (Army) UK (1971–75), Attached NBC Officer Region 1 US Mobilization Designee, DEA Officers' Course and UK Police Narcotics Squad Training (1973–78), 23 Special Air Service (1975–79) (Commanding Officer Rory Walker), RARO SAS (1979–97).
2008 David A. Karnofsky Award from the American Society of Clinical Oncology
2001 Bristol-Myers Squibb Award for Distinguished Achievement in Cancer Research.
2001 Doctor of Medicine,honoris causa from the University of Leeds
1993 ASPET Award from the American Society of Pharmacology and Experimental Therapeutics.
Top Twenty Cited Publications (Total Citations = 22,831 as of April 26, 2011)
- Cummings, S. R.; Eckert, S.; Krueger, K. A.; Grady, D.; Powles, T. J.; Cauley, J. A.; Norton, L.; Nickelsen, T. et al. (1999). "The effect of raloxifene on risk of breast cancer in postmenopausal women: Results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation". JAMA : the journal of the American Medical Association 281 (23): 2189–2197. PMID 10376571. (1,049 citations as of April 26, 2011).
- Furr, B. J.; Jordan, V. C. (1984). "The pharmacology and clinical uses of tamoxifen". Pharmacology & therapeutics 25 (2): 127–205. PMID 6438654. (730 citations as of April 26, 2011).
- Love, R. R.; Mazess, R. B.; Barden, H. S.; Epstein, S.; Newcomb, P. A.; Jordan, V. C.; Carbone, P. P.; Demets, D. L. (1992). "Effects of Tamoxifen on Bone Mineral Density in Postmenopausal Women with Breast Cancer". New England Journal of Medicine 326 (13): 852–856. doi:10.1056/NEJM199203263261302. PMID 1542321. (685 citations as of April 26, 2011).
- Jordan, V. C. (1984). "Biochemical pharmacology of antiestrogen action". Pharmacological reviews 36 (4): 245–276. PMID 6395141. (419 citations as of April 26, 2011).
- MacGregor, J. I.; Jordan, V. C. (1998). "Basic guide to the mechanisms of antiestrogen action". Pharmacological reviews 50 (2): 151–196. PMID 9647865. (430 citations as of April 26, 2011).
- Jordan, V.C. and Murphy, C. S. Endocrine pharmacology of antiestrogens as antitumor agents. Endocrine Reviews 11:578-610, 1990. (374 citations as of April 26, 2011).
- Gottardis, M. M., Robinson, S. P., Satyaswaroop, P.G., and Jordan, V.C. Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse. Cancer Research 48:812-815, 1988. (333 citations as of April 26, 2011).
- Lerner, L. J. and Jordan, V.C. Development of antiestrogens and their use in breast cancer (Eighth Cain Memorial award lecture). Cancer Research 50:4177-4189, 1990. (330 citations as of April 26, 2011).
- Gottardis, M. M. and Jordan, V.C. Development of tamoxifen-stimulated growth of MCF 7 tumors in athymic mice after long-term antiestrogen administration. Cancer Research 48:5183-5187, 1988. (321 citations as of April 26, 2011).
- Vogel, V.G., Costantino, J.P., Wickerham, D.L., Cronin, W.M., Cecchini, R.S., Atkins, J.N., Bevers, T.B., Fehrenbacher, L., Pajon (jr), E.R., Wade, J.L. III, Robidoux, A., Margolese, R.G., James, J., Lippman, S.M., Runowicz, C.D., Ganz, P.A., Reis, S.E., McCaskill-Stevens, W., Ford, L.G., Jordan, V.C., Wolmark, N. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. Journal of the American Medical Association 295:2727-41, 2006. (463 citations as of April 26, 2011).
- Cauley, J. A., Norton, L., Lippman, M. E., Eckert, S., Krueger, K. A., Purdie, D. W., Farrerons, J., Karasik, A., Mellstrom, D., Ng, K. W., Stepan, J. J., Powles, T. J., Morrow, M., Costa, A., Silfen, S. L., Walls, E. L., Schmitt, H., Muchmore, D. B., and Jordan, V. C. Continued breast cancer risk reduction in postmenopausal women treated with raloxifene: 4-year results from the MORE trial. Breast Cancer Research and Treatment 65: 125-134, 2001. (317 citations as of April 26, 2011).
- Love, R. R., Wiebe, D. A., Newcomb, P.A., Cameron, L., Leventhal, H., Jordan, V.C., Feyzi, J., and DeMets, D. L. Effects of tamoxifen on cardiovascular risk factors in postmenopausal women. Annals of Internal Medicine 115:860-864, 1991. (289 citations as of April 26, 2011).
- Gottardis, M. M., and Jordan, V.C. The antitumor actions of keoxifene (raloxifene) and tamoxifen in the N nitrosomethylurea-induced rat mammary carcinoma model. Cancer Research 47:4020-4024, 1987. (254 citations as of April 26, 2011).
- Love, R. R., Newcomb, P.A., Wiebe, D. A., Surawicz, T.S., Jordan, V.C., Carbone, P.P. and DeMets, D.L. Effects of tamoxifen therapy on lipid and lipoprotein levels in postmenopausal patients with node-negative breast cancer. Journal of National Cancer Institute 82:1327 1331, 1990. (246 citations as of April 26, 2011).
- Jordan, V.C., Phelps, E., and Lindgren J.U. Effects of antiestrogens on bone in castrated and intact female rats. Breast Cancer Research and Treatment 10:31-35, 1987. (221 citations as of April 26, 2011).
- Jiang, S.Y. and Jordan, V.C. Growth regulation of estrogen receptor negative breast cancer cells transfected with cDNA's for estrogen receptor. Journal of the National Cancer Institute 84:580-591, 1992. (213 citations as of April 26, 2011).
- Gottardis, M. M., Jiang, S.Y., Jeng, M.H., and Jordan, V.C. Inhibition of tamoxifen-stimulated growth of an MCF 7 tumor variant in athymic mice by novel steroidal antiestrogens. Cancer Research 49:4090 4093, 1989. (197 citations as of April 26, 2011).
- Trump, D. L., Smith, D.C., Ellis, P.G., Rogers, M.P., Schold, S .C., Winer, E. P., Ponella, T.J., Jordan, V.C., and Fine, R.L. High dose oral tamoxifen, a potential multidrug resistance reversal agent: Phase I trial in combination with vinblastine. Journal of the National Cancer Institute 84:1811-1816, 1992. (176 citations as of April 26, 2011).
- Jordan, V.C. A current view of tamoxifen for the treatment and prevention of breast cancer (Gaddum Memorial Lecture). British Journal of Pharmacology 110:507-517, 1993. (179 citations as of April 26, 2011).
- Jordan, V.C. and Allen, K.E. Evaluation of the antitumour activity of the nonsteroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model. European Journal of Cancer 16:239-251, 1980. (164 citations as of April 26, 2011).
- ^ Gupta, S. (2011). "Profile of V. Craig Jordan". Proceedings of the National Academy of Sciences. doi:10.1073/pnas.1117698108. PMID 22089238.
- ^ Jordan, V. C. (2008). "Tamoxifen: Catalyst for the change to targeted therapy". European Journal of Cancer 44 (1): 30–38. doi:10.1016/j.ejca.2007.11.002. PMC 2566958. PMID 18068350. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2566958.
- ^ Cummings, S. R.; Eckert, S.; Krueger, K. A.; Grady, D.; Powles, T. J.; Cauley, J. A.; Norton, L.; Nickelsen, T. et al. (1999). "The effect of raloxifene on risk of breast cancer in postmenopausal women: Results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation". JAMA : the journal of the American Medical Association 281 (23): 2189–2197. PMID 10376571.
- ^ Essential Science Indicators - Special Topics, Breast Cancer, Top 20 Papers in last two year period. Retrieved August 22, 2006.
- ^ , retrieved April 26, 2011
- ^ ASCO Special Awards: David A. Karnofsky Memorial Award Winners , retrieved August 26, 2009
- ^ Fox Chase Cancer Center Press Release, V. Craig Jordan Receives American Cancer Society Award for Chemoprevention , retrieved August 22, 2006
- ^ GM Cancer Kettering Winner, 2003 webpage. , retrieved August 22, 2006
- ^ American cancer Society Website (Cancer.org) press release, May 29, 2002  retrieved August 22, 2006
- ^ BBC News Queen's Birthday Honours List 2002, Diplomatic and Overseas , June 14, 2002. Retrieved August 22, 2006
- ^ Bristol-Myers Squibb Foundation Cancer Research Awards web page. retrieved August 22, 2006
- ^ University of Leeds press release; Conferment of the degree of Doctor of Medicine, honoris causa, upon Virgil Craig Jordan; July 18, 2001. Retrieved August 22, 2006
- ^ Northwestern University 1998 press release announcing Jordan's attendance at the May 17, American Society For Clinical Oncology Meeting.. Downloaded from Scienceblog.com, August 22, 2006
- ^ ASPET Awards List of Previous Awardees . Retrieved August 26, 2009
- ^ British Pharmacological Society web page on Prizes. Retrieved August 22, 2006
- ^ Komen.org web page on the 93rd annual meeting of the AACR, dated April 7, 2002 . Retrieved August 22, 2006
- ASBMB Today, July 2003(PDF), Page 6. Retrieved August 22, 2006
- PBS Online Newshour; New Drugs, New Hope. April 18, 1998, retrieved August 22, 2006
- US Department of Health HealthFinder website; Low dose estrogen may fight breast cancer, retrieved August 22, 2006
- University of Leeds press release; Conferment of the degree of Doctor of Medicine, honoris causa, upon Virgil Craig Jordan; July 18, 2001. Retrieved August 22, 2006
- Fox Chase Cancer Center press release V. Craig Jordan Joins Fox Chase Cancer Center, January 3, 2005. Retrieved August 22, 2006
- Observer Online, Northwestern University, Jordan receives OBE from Queen Elizabeth II, April 3, 2003. Retrieved August 23, 2006
- Texas A&M Health Science Center Extra, IBT Hosts Ninth Annual Kelsey Lecture, November 5, 2004. Retrieved August 23, 2006
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