Monoblast

Monoblast
Monoblast.png
Monoblast
Code TH H2.00.04.3.08002

Monoblasts are normally found in bone marrow and do not appear in the normal peripheral blood. They mature into monocytes which, in turn, develop into macrophages.

Contents

Structure

A typical monoblast is about 12 to 20 µm in diameter, has a nuclear to cytoplasm ratio of 4:1 to 3:1, and, like most myeloid blasts, has a round to oval nucleus with fine chromatin structure. One to four nucleoli are usually visible. The nucleus can be central or eccentric and it can show evidence of indentation or folding. The cytoplasm is agranular, stains moderately to lightly basophilic, and often has an intensely stained periphery and a prominent perinuclear zone.

Maturation

The monoblast is the first stage of monocyte-macrophage maturation. The developmental stages of the monoblast are: CFU-GM (pluripotential hemopoietic stem cell or hemocytoblast) -> monoblast -> promonocyte -> monocyte-> macrophage.

Additional images

See also



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Look at other dictionaries:

  • monoblast — MONOBLÁST s. n. celulă din care ia naştere monocitul. (< fr. monoblaste) Trimis de raduborza, 15.09.2007. Sursa: MDN …   Dicționar Român

  • monoblast — An immature cell that develops into a monocyte. [mono + G. blastos, germ] * * * mono·blast män ə .blast n a motile cell of the spleen and bone marrow that gives rise to the monocyte of the circulating blood * * * n. the earliest identifiable cell …   Medical dictionary

  • monoblast — n. immature monocyte, type of white blood cell that is not fully developed (Biology) …   English contemporary dictionary

  • monoblast — mono·blast …   English syllables

  • monoblast — n. the earliest identifiable cell that gives rise to a monocyte. It is probably identical with the myeloblast and matures via an intermediate stage (promonocyte). It is normally found in the blood forming tissue of the bone marrow but may appear… …   The new mediacal dictionary

  • monoblast — noun a large immature monocyte normally found in bone marrow • Hypernyms: ↑monocyte * * * ˌblast noun Etymology: International Scientific Vocabulary mon + blast : a motile cell of the spleen and bone marrow that gives rise to the monocyte of the… …   Useful english dictionary

  • Монобласт (Monoblast) — самая ранняя идентифицируемая клетка, из которой образуется моноцит (клетка предшественник моноцита). Монобласт, вероятно, можно считать идентичным миелобласту; он созревает, минуя промежуточную стадию (промоноцит (promonocyte)). Обычно… …   Медицинские термины

  • МОНОБЛАСТ — (monoblast) самая ранняя идентифицируемая клетка, из которой образуется моноцит (клетка предшественник моноцита). Монобласт, вероятно, можно считать идентичным миелобласту; он созревает, минуя промежуточную стадию (промоноцит (promonocyte)).… …   Толковый словарь по медицине

  • Hematopoietic stem cell — HSC=Hematopoietic stem cell, Progenitor=Progenitor cell, L blast=Lymphoblast, Lymphocyte, Mo blast=Monoblast, Monocyte, Myeloblast …   Wikipedia

  • Myeloblast — Code TH H2.00.04.3.04002 The myeloblast is a unipotent stem cell, which will differentiate into one of the actors of the Granulocyte series …   Wikipedia


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