Brodifacoum is a highly lethal
anticoagulant poison. In recent years, it has become one of the world's most widely used pesticides. It is typically used as a rodenticidebut is also used to control possums and other mammalian pestsEason, C.T. and Wickstrom, M. "Vertebrate pesticide toxicology manual", New Zealand Department of Conservation] .
Brodifacoum, like most anticoagulant poisons, has the advantage that one of its first effects is dehydration, forcing the rodent to move away from human habitation in search of water. As such, there is less chance that homeowners will be forced to deal with decomposing remains inside their building. Dehydrated bodies also dry out more readily, possibly leaving an odorless, mummified carcass.
Brodifacoum has a similar mode of action to
warfarin. However due to very high potency and long duration of action (elimination half-lifeof 20 – 130 days), it is characterised as a "second generation" or "superwarfarin" anticoagulant. [http://www.inchem.org/documents/hsg/hsg/hsg093.htm Brodifacoum (HSG 93, 1995) ] ]
Brodifacoum inhibits the
enzyme" Vitamin K epoxide reductase". This enzyme is needed for the reconstitution of the vitamin K in its cycle from vitamin K-epoxide, and so brodifacoum steadily decreases the level of active vitamin K in the blood. Vitamin K is required for the synthesis of important substances including prothrombin, which is involved in blood clotting. This disruption becomes increasingly severe until the blood effectively loses any ability to clot. In addition, brodifacoum (as with other anticoagulants in toxic doses) increases permeability of blood capillaries; the blood plasma and blood itself begins to leak from the smallest blood vessels. A poisoned animal will suffer progressively worsening internal bleeding, leading to shock, loss of consciousness, and eventually death.
Brodifacoum is highly lethal to mammals and birds, and extremely lethal to fish. It is a highly cumulative poison, due to its high
lipophilicityand extremely slow elimination.
Following are acute LD50 values for various animals (mammals) [http://www.inchem.org/documents/pds/pds/pest57_e.htm Brodifacoum (PDS) ] ] :
* rats (oral) 0.27—0.30 mg/kg b.w.
* mice (oral) 0.40 mg/kg b.w.
* rabbits (oral) 0.30 mg/kg b.w.
* guinea-pigs (oral) 0.28 mg/kg b.w.
* cats (oral) 0.25 mg/kg b.w.
* dogs (oral) 0.25 mg/kg b.w.LD50 values for various birds varies from about 1 mg/kg b.w. — 20 mg/kg b.w..
LC50 (concentration prone of killing 50% of animals exposed to it) for fish:
* trout (96 hours exposure) 0.04 ppm [http://www.wil-kil.com/public/2005-06_labels-msds/WeatherBlok%20XT%20M.pdf#search=%22LC50%2Bbrodifacoum%22]
Given these extremely high toxicities in various mammals, brodifacoum is classified as "extremely toxic" (LD50 < 1.0 mg/kg b.w.) and "very toxic" (T+; LD50 < 25 mg/kg b.w.), respectively. Because of its persistency, cumulative potential and high toxicities for various wildlife species, it is also considered an environmental pollutant (N; noxious to the environment).The readiness of brodifacoum to penetrate intact skin should be noted, and brodifacoum and commercial preparations containing it should be handled with respective care and precaution because of its skin resorptivity.
The estimated average fatal dose for an adult man (60 kg b.w.) is about 15 mg, without treatment. However, due to low bait concentrations (usually 10 — 50 mg/kg bait, i.e. 0.001 — 0.005%) and slow onset of symptoms, and the existence of a highly effective antidote (appropriately dosed vitamin K1), brodifacoum is considered to be of relatively low hazard to humans.
Brodifacoum is marketed under a large variety of trade names, including "d-Con", "Finale", "Fologorat", "Havoc", "Jaguar", "Klerat", "Matikus", "Mouser", "Pestoff", "Ratak+", "Rodend", "Talon", "Volak" and "Volid".
The primary antidote to brodifacoum poisoning is immediate administration of vitamin K1 (initially slow intravenous injections of 10-25 mg repeated all 3–6 hours until normalisation of the prothrombin time; then 10 mg orally four times daily as a "maintenance dose"). It is an extremely effective antidote, provided the poisoning is caught before too much damage has been done to the victim's circulatory system. As high doses of brodifacoum can affect the body for many months, the antidote must be administered regularly for a long period with frequent monitoring of the
If unabsorbed poison is still in the digestive system,
gastric lavagefollowed by administration of activated charcoalmay be required.
Another potential treatment is
phenobarbital, which is believed to accelerate the metabolism of some anticoagulants via enzyme induction.
The American Bird Conservancy has advocated that brodifacoum not be used by the general public. [ [http://www.abcbirds.org/abcprograms/policy/pesticides/Profiles/brodifacoum.html Pesticide Profile - Brodifacoum ] ] . They cite several studies indicating that secondary poisonings of predatory birds and animals are common due to the extreme persistance of the pesticide within both target and non-target species. It may also be dispersed by insects that feed on poisoned bait without harm and retain the pesticide within their bodies.
Poisoning case reports
There have been at least ten case reports of brodifacoum intoxication in the medical literature.
In one reportLipton, R.A. & Klass, E.M. (1984) "Human ingestion of a 'superwarfarin' rodenticide resulting in a prolonged anticoagulant effect." JAMA 252:3004-3005.] , a woman deliberately consumed over 1.5 kilograms of rat bait, constituting about 75 mg brodifacoum, but made a full recovery after receiving conventional medical treatment.
In another reportLa Rosa, F, Clarke, S. & Lefkowitz, J. B. (1997) "Brodifacoum intoxication with marijuana smoking." Archives of Pathology & Laboratory Medicine 121:67-69.] , a 17-year-old boy presented to the hospital with a severe bleeding disorder. It was discovered that he habitually smoked a mixture of brodifacoum and
marijuana. Despite treatment with vitamin K, the bleeding disorder persisted for several months. He eventually recovered.
New England Journal of Medicine, vol 356, no. 2, Jan. 11, 2007 Case Records of the Massachusetts General Hospital (a near fatal case of brodifacoum poisoning). [http://findarticles.com/p/articles/mi_qa3725/is_199701/ai_n8746745]
* Tasheva, M. (1995). "Environmental Health Criteria 175: Anticoagulant rodenticides." World Health Organisation: Geneva.
Wikimedia Foundation. 2010.
Look at other dictionaries:
Brodifacoum — Général No CAS … Wikipédia en Français
Brodifacoum — Strukturformel Struktur ohne Stereochemie Allgemeines Name … Deutsch Wikipedia
brodifacoum — noun A highly lethal anticoagulant poison used as a rodenticide … Wiktionary
brodifacoum — bro·di·fa·coum (broґdĭ fə k m) a long acting anticoagulant rodenticide … Medical dictionary
56073-10-0 — Brodifacoum Brodifacoum Général No CAS … Wikipédia en Français
C31H23BrO3 — Brodifacoum Brodifacoum Général No CAS … Wikipédia en Français
Rattengift — Ein Rodentizid ist ein chemisches Mittel zur Bekämpfung von Nagetieren. Es wird verwendet zur Herstellung von Fraßködern und zur Begasung von Lagerräumen und unterirdischen Nagetiergängen. Inhaltsverzeichnis 1 Wirkstoffe 1.1 Cumarine 1.1.1… … Deutsch Wikipedia
Rodentizide — Ein Rodentizid ist ein chemisches Mittel zur Bekämpfung von Nagetieren. Es wird verwendet zur Herstellung von Fraßködern und zur Begasung von Lagerräumen und unterirdischen Nagetiergängen. Inhaltsverzeichnis 1 Wirkstoffe 1.1 Cumarine 1.1.1… … Deutsch Wikipedia
Rodentizid — Warnschild in Chicagoer Wohnviertel nach dem Auslegen von Rattenköder … Deutsch Wikipedia
Rodenticide — A wild rat Rat poison redirects here. For the window manager, see ratpoison. Rodenticides are a category of pest control chemicals intended to kill rodents. Single feed baits are chemicals sufficiently dangerous that the first dose is sufficient… … Wikipedia