Apraclonidine

drugbox
IUPAC_name = 2,6-dichloro-"N"- (4,5-dihydro-1"H"-imidazol-2-yl) benzene-1,4-diamine



CAS_number = 66711-21-5
ATC_prefix = S01
ATC_suffix = EA03
ATC_supplemental =
PubChem = 2216
ChemSpiderID = 2130
DrugBank = APRD00012
C=9 | H=10 | Cl=2 | N=4
molecular_weight = 245.108 g/mol
bioavailability =
protein_bound = 98.7%
metabolism =
elimination_half-life = 8 hours
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category =
legal_AU =
legal_UK =
legal_US =
legal_status = Rx only
routes_of_administration = Ophthalmic solution

Apraclonidine (INN), also known as Iopidine, is a sympathomimetic used in glaucoma therapy. It is an α2-adrenergic agonist.

Apraclonidine is administered at a concentration of 1% for the prevention and treatment of postsurgical intraocular pressure elevation and 0.5% for short-term adjunctive therapy in patients on maximally tolerated medical therapy who require additional redirection of intraocular pressure. One drop is usually added one hour prior to laser eye surgery and another drop is given after the procedure is complete.

Clinical uses

Apraclonidine is indicated for the short-term adjunctive treatment of patients on maximally tolerated medical therapy who require additional IOP reduction. Patients on maximally tolerated medical therapy who are treated with apraclonidine to delay surgery should have frequent followup examinations and treatment should be discontinued if the intraocular pressure rises significantly.

External links

* [http://www.fda.gov/cder/foi/label/2002/19779slr014lbl.pdf Iopidine prescribing information] (from the FDA website)

References

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