- Palindromic sequence
A

palindrome is a word that is the same forward as it is backward such as the word "racecar", the name "Otto", or the saying attributed to Napoleon "Able was I ere I saw Elba". Certain sequences ofDNA are the same whether they are read 5' (five-prime) to 3'(three prime) or 3' to 5'. These sequences are called**palindromic**.Because a DNA sequence is double stranded, we read the base pairs not just the bases on one strand to determine a palindrome. The restriction enzyme EcoR1 recognizes the following palindromic sequence:

**5'- G A A T T C -3' 3'- C T T A A G -5'**the top strand reads 5'-GAATTC-3', while the bottom strand reads 3'-CTTAAG-5'. If you flip the DNA strand over, the sequences are exactly the same ( 5'GAATTC-3' and 3'-CTTAAG-5').

Palindromic sequences play an important role in

molecular biology . Manyrestriction endonucleases recognize specific palindromic sequences and cut them. Palindromic sequences may also bemethylation sites.Some palindromic sites and the restriction enzymes that they recognize follow.

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