- List of comic book drugs
This is a list of fictional performance enhancers, serums, trigger chemicals, booster drugs, and mutagenic foods in the various comic book universes, that were used to give a specific hero or villain their powers. This list also provides a brief summary of heroes who gained their powers from special concoctions like Captain America's Super Soldier Serum, Hourman's Miraclo and the original Blue Beetle's Vitamin 2X.
Developed by a scientist named Dr. Carter, who inoculated his two sons with the serum. It gave them super strength and superspeed, but left a "W" scar on their chest. Stan, the elder son, went on to become the Golden Age hero Lone Warrior, and his younger brother Dicky became his sidekick. First appears in Banner #3.
Secret Formula F22X
The formula was developed by Blaine Whitney, better known as Golden Age super hero the Wizard. In order to make his physical prowess match that of his super mental powers, he invented a serum that increased his strength to superhuman levels. First appears in Top-Notch Comics #1.
The SHIELD formula was designed by scientist Tom Higgins. He was killed by enemy agents before he could complete his research and fully develop the formula. Years later his son Jon Higgins was able to finish the formula. He rubbed it into his body, donned a special suit that allowed the chemical to be absorbed more easily, and then lay under fluoroscopic lamps in order to force the formula into his organs. When he emerged 12 hours later, he had developed the super powers that he used to fight crime as the Golden Age hero the Shield. First appears in Pep Comics #1.
A "singularly disturbing, sometimes permanently deranging and occasionally spectacularly fatal" drug used by Carrick Masterson to create the superheros in his super hero team The Levellers in the 1960s and again in his later group "The Front Line". "It's a less-than-friendly psychedelic whose positive effects include feelings of great strength and energy, intensification of the senses and general unusual stimulation. It also makes you poo yourself and be generally unpleasant to be around." 
A mutagenic steroid used by Jimmy Travis the Blitz of Earth A (Silver Age), and his sidekick Marty Eastman the Cyclone to gain superhuman speed. Unfortunately Cyclone became addicted to the pills and was forced to retire until he beat his addiction. Mack Snelling the Blitz of Earth B (Golden Age) also used Rocket Pills.
Demon from the Justice Machine took a special performance enhancing super drug to which he eventually became addicted. The drug granted him limited super speed, as well as enhanced reflexes and strength.
A drug from the comic Empowered, it grants 1/500 people who use it super-intelligence, at the price of cancer that kills within 24 hours. The other 499/500 end up simply getting cancer. A boy with cancer whom Empowered befriended gained his powers through the use of it, and at present is working to handle the side-effects.
Dr. Anabolus created an experimental super soldier serum which he tested on a puppy donated by the U.S. Army K-9 corps. The formula transformed the puppy into Rex the Wonder Dog. Rex gained increased speed, strength, stamina, agility, and intelligence. Dr. Anabolus was killed by a Nazi spy shortly after, leaving Rex as the only proof of his formula's existence. First appears in Rex the Wonder Dog #1.
Invented by Brainiac 5, this serum protected Daxamites from the effects of lead, which affects them like Kryptonite affects Superman. The serum also allowed Mon-El to keep his powers on worlds with a red sun.
The mutagenic compound called Apocritic made from Starro DNA by Checkmate scientists. The drug allows special field operatives designated as Rooks to maintain a telepathic link at the risk of summoning Starro to Earth.
A formula developed by Alec Holland to increase the growth of plants. When a bomb exploded in his lab, Holland was doused with the burning fluid and ran dying into the Louisiana bayou. The formula combined the consciousness of Alec Holland and the swamp plants to form Swamp Thing. Before the accident, Holland calculated that 300,000,000 gallons of the Bio-Restorative Formula could have turned a desert the size of California's Mojave into a fertile crop field. From Swamp Thing #1.
Chemical warfare agent developed during the Vietnam War. An allegory of Agent Orange, it was discontinued because it was felt to be too dangerous. It was later used by a local cult leader in Cambodia who discovered that it left those exposed open to suggestion. First appears in Captain Atom #47.
A drug created by Dr. Michael Grant, that when spilled into the water supply, gave human intelligence to the animals who drank it. This intelligence was passed down to their descendants, resulting in the talking animals of Kamandi's time. First mentioned in Kamandi #16.
When eaten by Roger Rodney Rabbit (Captain Carrot), they dramatically enhance his physical characteristics for roughly 24 hours, depending on his physical exertion. They grew in soil contaminated by a radioactive meteor fragment (Captain Carrot and his Amazing Zoo Crew #1)
An addictive mutagen that transforms its users into pseudo-demons, the users becoming increasingly violent as they approach the end of their 'high'. Created by Lord Satanus in Adventures of Superman #534.
The Exo-gene (also exogene) is a toxic gene therapy treatment created by Lexcorp for the Everyman Project. Unlike the genetically inherited Metagene, the Exo-gene can grant superhuman powers to anyone tested and found compatible, but it can potentially cause massive organ failure six months later. The exo-gene can be disrupted by an electromagnetic pulse or deactivated completely by mechanical means. First appears in 52 #4, first announcement of the Everyman Project in 52 #8.
A gaseous toxin invented by an unstable psychologist named Jonathan Crane (alias the Scarecrow). Fear Toxin causes its victims to experience their greatest fears and assorted phobias, and if taken in large enough doses it may have prolonged mutagenic properties. According to comments made by the Signalman in Justice League of America #1 (2006) it has also become a recreational drug for teenagers.
A special formula made from a rare tropical fruit called Gingo, that grants the Elongated Man (Ralph Dibny), and Stretch from Hero Hotline their unique stretching abilities; Gingo is also used in Gingold brand cola. It was revealed in Invasion! #3 that it is a metagene reaction to Gingold that grants Ralph Dibny his stretching powers, and ordinary humans will not develop stretching powers after using Gingold. (Although, in the pages of 52, Ralph successfully used it on an unconscious demon, tying up its then-rubbery body.) Normal humans are supposedly highly allergic to the concentrated form of Gingo used by Dibny. Gingold is also used in the Pseudoderm material from which the Question's mask is made.
Introduced in the pages of Hawkworld, a drug that slowly transforms its users into feral werebeasts. The more they use, the more feral and out of control they become, as demonstrated by FerAlyse and other denizens of Chicago's Netherworld. It was introduced in Hawkworld #30.
Ilium 349 is a special rare earth element like Kryptonite, which was found only in the Pre-Crisis version of the bottle city of Kandor. Ilium 349 was discovered by renegade Kandorian scientist Zak-Kul who used it to create a device which could be used to either shrink or enlarge a person or city.
Ivo's Immortality Serum
KT-28s, or Katies, are a fictitional psychoactive drug in Watchmen. Later on in the novel, Dr Manhattan states that he can synthesize limitless amounts of lithium which would lead to advances in technology. Lithium is also used as a drug in psychiatric treatment and the term KT-28, which sounds more like an official pharmaceutical name, implies a legitimate drug which has somehow found its way onto the streets.
Drug from Thanagar that allows a person to shapeshift. It only works once on a human, but a Thanagarian can change their shape an unlimited amount of times. It is highly addictive and prolonged users become incapable of retaining a cohesive shape if not given the drug regularly. Used and trafficked to Earth by the Thanagarian criminal Byth. Introduced in the pages of Hawkworld. Pre-Crisis, Krotan was the name of a scientist who invented a similar drug called the Changeling Pill.
The various chemicals native to Lazarus Pits have demonstrated the ability to resurrect the dead; upon resurrection the subjects exhibit temporary dementia. The substance that fills each pit was originally a chemical blend of unknown composition, until Kobra recreated their unique chemical composition. Ra's al Ghul and Kobra each had their own secret network of Lazarus Pits, and because of their necessity to the Earth's survival, Batman also created a Lazarus Pit in the Batcave.
A powerful mutagen used by Sean Erin to induce a sex-change, changing him from male to the female Shvaugn Erin, for the express purposes of attracting Element Lad. First appears in Legion of Super Heroes #31.
A drug that apparently regulates and slows down the accelerated metabolism of super-speedsters in the DC Universe. Unlike most speedsters, Eliza Harmon (Trajectory of Infinity Inc.) was unable to slow her highly accelerated perceptions of the world around her and so turned to the drug. First used in the pages of 52 #17.
Soul is a street drug from Gotham City created by "Doctor Death". It has one of two effects on a person, it either enhances their best qualities or bring out their worst qualities. It is apparently produced from rendered corpses.
Unlike the Flash, Johnny Quick from the Crime Syndicate of Amerika receives his powers by injecting himself with an enhancer drug called "Speed Juice". Whether Speed Juice has any relationship to Velocity 9 is unknown at this time.
A medication originally developed to treat the rare medical condition xenoderma pigmentosum, it later surfaces as an addictive street drug that turns its habitual users into mindless super-strong zombies. This drug mixed with alcohol and adrenaline was responsible for Dr. Pieter Cross gaining the ability to see in the dark. He used this ability to become the new Doctor Mid-Nite. From the Doctor Mid-Nite mini-series.
Addictive and illegal street drug that causes rapid physical mutation and grants the user limited super strength.
A highly addictive drug that grants temporary super speed, but speeds up the body's metabolism leading to dehydration, severe exhaustion, psychosis and what looks like rapid aging, but is actually the body feeding off itself to a super accelerated degree. Within a very short time of regularly using, after the user would shoot up, which would physically invigorate their bodies for an undetermined amount of time, as the drug wore off, they would begin to wither to an emaciated state within hours. Upon using again, they would quickly revert to their normal size and strength, quickly taking the opportunity to find more money to feed their habits. Most addicts became temporary super-criminals using their super-speed to steal to get money for more Velocity-9, repeating this cycle over and over again until they damaged their body to a sometimes fatal degree. While the formula mimicked the same aura that protected the Flashes against friction and other factors associated with traveling at super-speed, it did not completely protect against the shock traveling at such a speed would have on the body. Many former addicts became invalids afterwards with organ failure and permanent warping of their bones from the constant stress and micro-fractures from their running. One of the first addicts to confront the Flash was a friend of his whose mind had been twisted from using to such a degree that he became Flash's short lived arch enemy, even going as far as to don a costume and terrorizing his loved ones and friends. Once captured and clean of the drug, he spent months in physical rehabilitation to try and fight the crippling effects the drug had on his body, with the Flash checking up on him periodically after they reconciled their friendship. The original formula, developed by Edward Clariss, had no such side effects, but the effects were only temporary. It was the subsequent impure version of the formula that would become the street drug that, for a time, plagued the speedsters. Later Deathstroke was able to fashion a particular variant of Velocity 9 devoid of any ill-effects, for Inertia's use. While this version does not have any debilitating effects on the body, it is not known whether it still has the same addictive qualities. If Inertia is the only known example of using this new formula, then the way he reacts to not having a supply of it may very well confirm its addictiveness.
A derivative of Velocity 9, this drug also granted its users super speed but with a different consequence: It caused different parts of the body to metabolize at different rates.
Venom is a potently addictive strength-enhancing super-steroid. According to JSA Classified #17 (November 2006), Venom is potent variant based on the Miraclo formula developed at Bannerman Pharmaceuticals, the drug company formerly owned by Rex Tyler, the original Hourman although it does not have the same 60 minute limitation as Miraclo. The drug, usually injected in a constant supply into the base of the neck would instantly transform someone into a hulking mass of unbridled physical strength. Bane's apparatus included a special "boost" button to give him a jolt of Venom when needed. However, as the drug wore off or when the user was cut off from its constant supply, their body would rapidly return to its original state or sometimes even weaker, at which point the user would suffer from massive, debilitating withdrawal, usually accompanied by terrible, frightening hallucinations. The first appearance of the drug was a five-part story arc, Batman: Venom, in Legends of the Dark Knight issues 16-20. Batman became addicted to the drug while searching for a way to cope for his physical limitations and imperfections, forcing him to eventually lock himself in the Batcave to "detox" himself when he realized how dependent on it he had become. Later, it resurfaced as the power source for Bane, who used it to overpower and cripple Batman by breaking his back over his knee in the Knightfall story arc. A version of it, spiked with a metabolizing form of kryptonite, was used by President Lex Luthor in the first "Superman/Batman" story arc, prompting Batman to speculate that Luthor's use of Venom may be responsible for his recent, more "outlandish" schemes, such as attempting to accuse Superman of being responsible for a kryptonite meteorite the size of Texas heading for Earth.
In the Batman Beyond universe, steroid patches known as "Slappers" contained small doses of impact-release Venom. They were mainly used as performance enhancers in competitive sports, although the use of multiple patches could produce Bane-like combat abilities. However, if extensively used, the Slappers would eventually cripple the user as a side effect.
In the Burton/Schumacher film series, Venom is engineered by Pamela Isley (Poison Ivy) to be injected into plants for the power to defend themselves like animals. Her coworker Dr. Woodrue steals samples of base Venom and reengineers it with steroids and toxins to create a super soldier army of which Bane is the prototype. Venom appears to have the same physical reaction after injection, but leaves the user mindless and insensate. Venom is also part of Isley's transformation into Poison Ivy. Woodrue calls Venom his "super soldier serum," invoking the name of the formula used to create Captain America in a similar fashion in the Marvel universe.
In the video game, Batman: Arkham Asylum, a Dr. Penny Young, an Arkham doctor, manufactures a more powerful form of Venom codenamed "Titan," under the orders of Jack White, AKA the Joker, believing that Titan's strength-enhancing properties could be used to help patients better cope with the physical treatment they would have to endure during their therapy. Bane is later unwillingly reinjected with Venom (Since, at this point he had beaten his addiction to the drug and considered it to be a crutch and a handicap and only used by the weak) by Joker to kill Batman. The Joker later reveals that he plans to use the upgraded "Titan" drug to make his army to conquer Gotham City. After Batman defeats Joker's thugs and his Titan-fueled lackeys, Joker tries to shoot Commissioner Gordon with a Titan dart, but Batman takes the dart, using a Titan antidote he had developed earlier on himself even after Joker injects himself with Titan, preferring to fight his own way rather than allowing the Joker to provoke him into using his methods. Titan-Joker nearly kills Batman in his advanced form, but is later electric shocked and returns to normal. The final cutscene shows Bane, Killer Croc, or Scarecrow gaining possession of a crate full of Titan (depending on the player's completion rate).
In the series Young Justice, Santa Prisca, the birth place of Venom, is depicted as the single largest manufacturer of the drug, but suddenly it began hoarding it, Batman sent the Young Justice team in to find out why. Eventually it's revealed that the Cult of Kobra has begun hoarding the Venom in order to develop a Venom/Blockbuster-hybrid drug, the resulting combination creating a permanent transformation combining the strength of both transformations. By the end of the episode Santa Prisca is destroyed along with the Venom manufacturing plant and the hybrid formula. Sportsmaster however is able to deliver a single vial of the formula to the Light, a shadow organization, from which they will be able to reverse engineer more.
A mysterious chemical created by the scientists of Advanced Idea Mechanics. When a tanker carrying Compound X07 was involved in an accident with a church bus, the lone survivor, who had been thoroughly drenched in the compound, gained lightning-fast healing and became insensitive to pain. He eventually became the costumed individual known as Madcap. The chemical may or may not have contributed to his mental instability. First appears in Captain America #307.
A narcotic described as "ultra-addictive" that originated in Atlantis and made its way to the surface. Treated as a narcotic by Atlanteans, when used on humans it makes them aggressive. Hook-addicted humans secrete an enzyme that, if harvested, can be turned into a separate narcotic.
The powerful serum that keeps Nick Fury youthful (a.k.a. an immortality drug). He needs to receive an annual injection of the formula or he will rapidly age 60 years. Developed by a French scientist, Dr. Berthold Sternberg and initially given to Fury in an attempt to save his life near the end of World War II when he was injured by a land mine. Introduced in Marvel Spotlight #31.
A highly addictive drug dispensed via inhalant, that enhances special abilities in mutants. Later discovered to be an aerosol compound for distributing a primordial microorganism known only as Sublime. Used by Xorn, Jumbo Carnation, Quentin Quire, and Sophie of the Stepford Cuckoos. The active ingredient is Hypercortisone-D.
Mutant Growth Hormone
Also known as MGH, is a drug extracted from the genetic material of superpowered individuals, that grants temporary powers to whoever takes it. Sometimes used as a party drug, MGH often results in increased strength and aggression. Also, when given to an already super-powered individual, it enhances their abilities further.
A drug developed by Osborn Industries in the Ultimate Marvel universe that indirectly granted that universe's Peter Parker his powers when he was bitten by an Oz-injected spider. Also gave the Green Goblin and Hobgoblin their powers.
A highly addictive street drug that temporarily boosts a mutant's power.
Red, White & Blue
Serum SO-2 was a mutagen developed as part of Project Sulfur to provide immunity for soldiers against biological warfare; the experiment was abandoned when it was noted that the serum had the unfortunate side effect of horribly mutating its recipients into monstrous freaks. Later Ted Sallis injects the serum into his own body in an attempt to keep it out of the hands of A.I.M. agents, the serum transforms Sallis into Man-Thing. First appears in Savage Tales #1.
A gaseous form of the Super Soldier Serum that grants increased speed, strength, and endurance. From the Underworld mini-series.
Super Soldier Serum
The drug from which Captain America, Isaiah Bradley, Patriot, Protocide and Josiah X get their enhanced abilities. Developed by Dr. Abraham Erskine to enhance all the physical and mental abilities to the pinnacle of human ability. In Marvel: Ultimate Alliance, when scientists have planned to recreate the serum, they ended up creating the giants that are seen in the Omega Base.
In Spider-Man: The Animated Series, the serum was used on Felicia Hardy which eventually turned her into the Black Cat. In the film Captain America: The First Avenger, it was also responsible for turning Johann Schmidt into the Red Skull due to a combination of it not being perfected during that time as well as Schmidt's dark inner nature, and it is also implied in the 2008 Incredible Hulk film that a version of the Super Soldier Serum, is used on Emil Blonsky.
A dangerous mutagen used by the Inhumans to induce random mutations in their youth during a rite of passage ceremony. Humans exposed to the mist temporarily gain super-powers, but eventually suffer from degenerative mutations followed by death. Depowered Mutants experience a temporary return of their powers but with uncontrollable and unpredictable side-effects. The mists themselves are a by product of Terrigen crystals. First used on mutants in the Son of M mini-series.
A purified form of Zap. It grants the user an incredible euphoria, heightened strength, increased endurance and an inability to feel pain. It also causes death in one hour. Thunderbolt was developed by a Dr. Malheur and marketed by the Yakuza. The act of taking the drug was known as "riding the thunderbolt". As shown in Wolverine #31.
Lamesis was a supposedly long lost formula from Ancient Egypt that granted its drinker superstrength. It was used by Nelson Drew to become a Golden Age hero known as the Liberator. From Exciting Comics #15.
The Devil Fruits are a class of fruits that permanently grant supernatural powers in the manga One Piece. Main character Monkey D. Luffy's body gained the properties of rubber after he ate one; numerous other characters have been given unique powers of their own from other Devil Fruits. While each Devil Fruit grants a different power, they share a common weakness: the user can no longer swim, and in fact loses all strength when immersed in sea water.
These are a form of nutritional supplement pellets sometimes used in the manga Naruto. By taking a single pellet a ninja's chakra can be replenished or boosted drastically. They are said to allow a ninja 'to fight for three days and three nights without rest'.
The villain Mr. Calder in the manga series Zombie Powder took the drug Phenixamin to sustain his young appearance. However, because he used the drug so often he had to take higher doses which is what lead him to seek the Zombie Powder.
In various episodes/chapters of the manga and anime Dragon Ball, many of the fighters took Senzu Beans to restore their health. They have the added effect of keeping the user full and energetic for ten days. They also allowed the user to overcome certain illnesses.
A medicine developed by the character Tony Tony Chopper in One Piece, the Rumble Ball interacts with his Devil Fruit powers to allow him to transform into several additional forms. However, overdoses may cause him to lose control of his transformations, or even turn him into a giant, mindless monster.
A powerful and addictive narcotic from the manga series Cowboy Bebop. The drug is administered via an aerosol solution sprayed directly into the user's eyes. It grants the user periodic surges of superhuman strength, and limited super speed and reflexes sufficient to dodge bullets. Popular belief is that parts of the drug functioned like a cholinergic nootropic in that they temporarily increased the brain's supply of neurotransmitters, allowing users to process environmental and spatial information so quickly that all normal human movement and action appears to be in slow motion.
The sand from Morpheus's pouch. Originally stolen when Morpheus was captured by the Order of Ancient Mysteries, the sand eventually ended up in the hands of John Constantine. His ex-girlfriend stole the pouch and had spent the past several years using the sand to give herself constant dreams, to the detriment of her overall health. From the pages of Sandman #3.
This is the strange material of uncertain, perhaps extraterrestrial, perhaps secret government origin that the former police-officer detective known as "S" steals to sell at a very high price to a mysterious art collector in Paul Pope's 5-issue mini-series Heavy Liquid. In its natural state, Heavy Liquid is something of a liquid metallic explosive, but when the volatile substance is heated it turns into a milky, black ooze that has a narcotic/psychedelic effect when 'ingested' through the ear.
An unknown blue mutagen which when introduced via syringe, transforms humans into superhumans. First appears in The Boys #4.
Bitter-tasting root from the mysterious island Attabar Teru. When taken, it magnifies the average human's life span and intellect. Used by Tom Strong, his wife Dhalua Strong and his daughter Tesla Strong. See Tom Strong #1.
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- ^ As seen in Checkmate #25 June 2008
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- ^ The Flash: The Fastest Man Alive
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- ^ More Fun Comics #73
- ^ Abnett, Dan, Lanning, Andy (w), Walker, Brad (p), Hennessy, Andrew (i). "Are You For Hire?" Heroes for Hire v3, 1 (December 2010), Marvel Comics
- ^ Man-Thing - Marvel Universe: The definitive online source for Marvel super hero bios
- ^ AMR: 8 Man After
- ^ AnimeInfo.org - Cowboy Bebop Library - Big Shot Lineup
- Comic Book Drug Reference
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- CBR Oddball Comics: Action Comics #421
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- Mighty Crusaders Handbook: The Wizard
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- Superman Homepage entry for Captain Strong
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