Tetraspanin

Tetraspanin family
Tetraspanin Figure.jpg
Tetraspanins have four transmembrane domains, two extracellular loops and contain a series of highly conserved amino acid residues.
Identifiers
Symbol Tetraspannin
Pfam PF00335
Pfam clan CL0347
InterPro IPR000301
PROSITE PDOC00371
SCOP 1iv5
CDD cd03127

Tetraspanins are a family of membrane proteins found in all multicellular eukaryotes.

Tetraspanins, also called tetraspans or the transmembrane 4 superfamily (TM4SF), have four transmembrane domains, intracellular N- and C-termini and two extracellular domains, one short (called the small extracellular domain or loop, SED/SEL or EC1) and one longer, typically 100 amino acid residues (the large extracellular domain/loop, LED/LEL or EC2). Although several protein families have four transmembrane domains, tetraspanins are defined by conserved domains listed in the Protein Families database under pfam00335.12.[1] The key features are four or more cysteine residues in the EC2 domain, with two in a highly conserved 'CCG' motif.

Research into this field is relatively recent (less than 20 years) and therefore there is much to learn about the function of specific tetraspanins. Generally, tetraspanins are often thought to act as scaffolding proteins, anchoring multiple proteins to one area of the cell membrane.[2]

Tetraspanins are highly conserved between species. Some tetraspanins can have N-linked glycosylations on the long extracellular loop (LEL, EC2) and palmitoylations at a CXXC motif in their transmembrane region.[3]

There are 34 tetraspanins in mammals, 33 of which have also been identified in humans. Tetraspanins display numerous properties that indicate their physiological importance in cell adhesion, motility, activation and proliferation, as well as their contribution to pathological conditions such as metastasis or viral infection.

A role for tetraspanins in platelets was demonstrated by the bleeding phenotypes of CD151- and TSSC6-deficient mice, which exhibit impaired "outside-in" signalling through αIIbβ3, the major platelet integrin. it is hypothesized that tetraspanins interact with and regulate other platelet receptors.[4]

Contents

List of human tetraspanins

Protein Gene Aliases
TSPAN1 TSPAN1 TSP-1
TSPAN2 TSPAN2 TSP-2
TSPAN3 TSPAN3 TSP-3
TSPAN4 TSPAN4 TSP-4, NAG-2
TSPAN5 TSPAN5 TSP-5
TSPAN6 TSPAN6 TSP-6
TSPAN7 TSPAN5 CD231/TALLA-1/A15
TSPAN8 TSPAN8 CO-029
TSPAN9 TSPAN9 NET-5
TSPAN10 TSPAN10 OCULOSPANIN
TSPAN11 TSPAN11 CD151-like
TSPAN12 TSPAN12 NET-2
TSPAN13 TSPAN13 NET-6
TSPAN14 TSPAN14
TSPAN15 TSPAN15 NET-7
TSPAN16 TSPAN16 TM4-B
TSPAN17 TSPAN17
TSPAN18 TSPAN18
TSPAN19 TSPAN19
TSPAN20 UPK1B UP1b, UPK1B
TSPAN21 TSPAN21 UP1a, UPK1A
TSPAN22 PRPH2 RDS, PRPH2
TSPAN23 TSPAN23 ROM1
TSPAN24 CD151 CD151
TSPAN25 CD53 CD53
TSPAN26 CD37 CD37
TSPAN27 CD82 CD82
TSPAN28 CD81 CD81
TSPAN29 CD9 CD9
TSPAN30 CD63 CD63
TSPAN31 TSPAN31 SAS
TSPAN32 TSPAN32 TSSC6
TSPAN33 TSPAN33
TSPAN34 TSPAN34

See also

Relevance to parasite vaccines

The schistosome worms make two tetraspanins: TSP-1 and TSP-2. TSP-2 antibodies are found in some people who seem to have immunity to schistosome infection (Schistosomiasis).[5]

External links

References

  1. ^ Pfam
  2. ^ Hemler ME (2005). "Tetraspanin functions and associated microdomains". Nat. Rev. Mol. Cell Biol. 6 (10): 801–11. doi:10.1038/nrm1736. PMID 16314869. 
  3. ^ Wright MD, Tomlinson MG (1994). "The ins and outs of the transmembrane 4 superfamily". Immunol. Today 15 (12): 588–94. doi:10.1016/0167-5699(94)90222-4. PMID 7531445. 
  4. ^ Goschnick MW, Lau LM, Wee JL, Liu YS, Hogarth PM, Robb LM, Hickey MJ, Wright MD, Jackson DE (2006). "Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice". Blood 108 (6): 1911–8. doi:10.1182/blood-2006-02-004267. PMID 16720835. 
  5. ^ Scientific American May 2008, referring to McManus & Loukas Clinical Microbiology reviews V21,N1,p225-242 (Jan 2008)

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • tetraspanin — noun A tetraspan …   Wiktionary

  • TSPAN2 — Tetraspanin 2, also known as TSPAN2, is a human gene.cite web | title = Entrez Gene: TSPAN2 tetraspanin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=10100| accessdate = ] PBB Summary section title =… …   Wikipedia

  • TSPAN7 — Tetraspanin 7, also known as TSPAN7, is a human gene.cite web | title = Entrez Gene: TSPAN7 tetraspanin 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7102| accessdate = ] PBB Summary section title =… …   Wikipedia

  • TSPAN4 — Tetraspanin 4, also known as TSPAN4, is a human gene.cite web | title = Entrez Gene: TSPAN4 tetraspanin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7106| accessdate = ] PBB Summary section title =… …   Wikipedia

  • TSPAN8 — Tetraspanin 8, also known as TSPAN8, is a human gene.cite web | title = Entrez Gene: TSPAN8 tetraspanin 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7103| accessdate = ] PBB Summary section title =… …   Wikipedia

  • TSPAN32 — Tetraspanin 32, also known as TSPAN32, is a human gene.cite web | title = Entrez Gene: TSPAN32 tetraspanin 32| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=10077| accessdate = ] PBB Summary section title …   Wikipedia

  • TSPAN6 — Tetraspanin 6, also known as TSPAN6, is a human gene.cite web | title = Entrez Gene: TSPAN6 tetraspanin 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7105| accessdate = ] PBB Summary section title =… …   Wikipedia

  • TSPAN3 — Tetraspanin 3, also known as TSPAN3, is a human gene.cite web | title = Entrez Gene: TSPAN3 tetraspanin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=10099| accessdate = ] PBB Summary section title =… …   Wikipedia

  • TSPAN13 — Tetraspanin 13, also known as TSPAN13, is a human gene.cite web | title = Entrez Gene: TSPAN13 tetraspanin 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=27075| accessdate = ] PBB Summary section title …   Wikipedia

  • TSPAN31 — Tetraspanin 31, also known as TSPAN31, is a human gene.cite web | title = Entrez Gene: TSPAN31 tetraspanin 31| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=6302| accessdate = ] PBB Summary section title …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.