Retinoic acid receptor


Retinoic acid receptor

protein
Name = retinoic acid receptor alpha
caption =


width =
HGNCid = 9864
Symbol = RARA
AltSymbols =
EntrezGene = 5914
OMIM = 180240
RefSeq = NM_000964
UniProt = P10276
PDB =
ECnumber =
Chromosome = 17
Arm = q
Band = 12
LocusSupplementaryData =
protein
Name = retinoic acid receptor beta
caption =


width =
HGNCid = 9865
Symbol = RARB
AltSymbols =
EntrezGene = 5915
OMIM = 180220
RefSeq = NM_000965
UniProt = P10826
PDB =
ECnumber =
Chromosome = 3
Arm = p
Band = 24
LocusSupplementaryData =
protein
Name = retinoic acid receptor gamma
caption =


width =
HGNCid = 9866
Symbol = RARG
AltSymbols =
EntrezGene = 5916
OMIM = 180190
RefSeq = NM_000966
UniProt = P13631
PDB =
ECnumber =
Chromosome = 12
Arm = q
Band = 13
LocusSupplementaryData =
The retinoic acid receptor (RAR) is a type of nuclear receptorcite journal |author=Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H|title=International Union of Pharmacology. LX. Retinoic acid receptors |journal= Pharmacol Rev |volume= 58 |issue= 4 |pages= 712–25 |year= 2006| doi = 10.1124/pr.58.4.4 |pmid= 17132850] which is activated by both all-trans retinoic acid and 9-cis retinoic acid.cite journal |author=Allenby G, Bocquel MT, Saunders M, Kazmer S, Speck J, Rosenberger M, Lovey A, Kastner P, Grippo JF, Chambon P, Levin AA|title=Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids |journal= Proc Natl Acad Sci U S A |volume= 90 |issue= 1 |pages= 30–4 |year= 1993| doi = 10.1073/pnas.90.1.30 |pmid= 8380496] There are three retinoic acid receptors (RAR), RAR-alpha, RAR-beta, and RAR-gamma encoded by the gene|RARA, gene|RARB, gene|RARG genes respectively. Each receptor isoform has several splice variants: two- for alpha, four- for beta and two- for gamma.

As with other type II nuclear receptors, RAR heterodimerizes with RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements complexed with corepressor protein. Binding of agonist ligands to RAR results in dissociation of corepressor and recruitment of coactivator protein which in turn promotes transcription of the downstream target gene into mRNA and eventually protein.

ee also

* Retinoid X receptor

References

External links

*


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