Bone morphogenetic protein 3

Bone morphogenetic protein 3

Bone morphogenetic protein 3 (osteogenic), also known as BMP3 or osteogenin, is a human gene.cite web | title = Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)| url =| accessdate = ]

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors.

It is highly expressed in fractured tissues.


Further reading

citations =
*cite journal | author=Dickinson ME, Kobrin MS, Silan CM, "et al." |title=Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. |journal=Genomics |volume=6 |issue= 3 |pages= 505–20 |year= 1990 |pmid= 1970330 |doi=
*cite journal | author=Tabas JA, Zasloff M, Wasmuth JJ, "et al." |title=Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3. |journal=Genomics |volume=9 |issue= 2 |pages= 283–9 |year= 1991 |pmid= 2004778 |doi=
*cite journal | author=Paralkar VM, Nandedkar AK, Pointer RH, "et al." |title=Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen. |journal=J. Biol. Chem. |volume=265 |issue= 28 |pages= 17281–4 |year= 1990 |pmid= 2211625 |doi=
*cite journal | author=Rosen V, Wozney JM, Wang EA, "et al." |title=Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone. |journal=Connect. Tissue Res. |volume=20 |issue= 1-4 |pages= 313–9 |year= 1990 |pmid= 2612162 |doi=
*cite journal | author=Wozney JM, Rosen V, Celeste AJ, "et al." |title=Novel regulators of bone formation: molecular clones and activities. |journal=Science |volume=242 |issue= 4885 |pages= 1528–34 |year= 1989 |pmid= 3201241 |doi=
*cite journal | author=Faucheux C, Ulysse F, Bareille R, "et al." |title=Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation. |journal=Biochem. Biophys. Res. Commun. |volume=241 |issue= 3 |pages= 787–93 |year= 1998 |pmid= 9434787 |doi= 10.1006/bbrc.1997.7792
*cite journal | author=Daluiski A, Engstrand T, Bahamonde ME, "et al." |title=Bone morphogenetic protein-3 is a negative regulator of bone density. |journal=Nat. Genet. |volume=27 |issue= 1 |pages= 84–8 |year= 2001 |pmid= 11138004 |doi= 10.1038/83810
*cite journal | author=Jin Y, Lu HB, Liong E, "et al." |title=Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors. |journal=Histol. Histopathol. |volume=16 |issue= 4 |pages= 1013–9 |year= 2002 |pmid= 11642720 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kloen P, Di Paola M, Borens O, "et al." |title=BMP signaling components are expressed in human fracture callus. |journal=Bone |volume=33 |issue= 3 |pages= 362–71 |year= 2004 |pmid= 13678778 |doi=
*cite journal | author=Kang Q, Sun MH, Cheng H, "et al." |title=Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. |journal=Gene Ther. |volume=11 |issue= 17 |pages= 1312–20 |year= 2004 |pmid= 15269709 |doi= 10.1038/
*cite journal | author=Chen AL, Fang C, Liu C, "et al." |title=Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage. |journal=J. Orthop. Res. |volume=22 |issue= 6 |pages= 1188–92 |year= 2004 |pmid= 15475196 |doi= 10.1016/j.orthres.2004.02.013
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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