Estrogen receptor alpha

Estrogen receptor 1

PDB rendering based on 1a52.
Identifiers
Symbols ESR1; DKFZp686N23123; ER; ESR; ESRA; Era; NR3A1
External IDs OMIM133430 MGI1352467 HomoloGene47906 IUPHAR: NR3A1 GeneCards: ESR1 Gene
Orthologs
Species Human Mouse
Entrez 2099 13982
Ensembl ENSG00000091831 ENSMUSG00000019768
UniProt P03372 P19785
RefSeq (mRNA) NM_000125.3 NM_007956.4
RefSeq (protein) NP_000116.2 NP_031982.1
Location (UCSC) Chr 6:
151.98 – 152.45 Mb
Chr 10:
5.34 – 5.73 Mb
PubMed search [1] [2]

Estrogen receptor alpha (ER-α), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is a nuclear receptor that is activated by the sex hormone estrogen. In humans, ER-α is encoded by the gene ESR1 (EStrogen Receptor 1).[1][2][3]

Contents

Structure

The estrogen receptor (ESR) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription.[4] Alternative splicing results in several ESR1 mRNA transcripts, which differ primarily in their 5-prime untranslated regions. The translated receptors show less variability.[5][1]

Coactivators

Coactivators of ER-α include:

Interactions

Estrogen receptor alpha has been shown to interact with:


References

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Further reading

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  • Lannigan DA (2003). "Estrogen receptor phosphorylation". Steroids 68 (1): 1–9. doi:10.1016/S0039-128X(02)00110-1. PMID 12475718. 
  • Herrington, David M. (2003). "Role of estrogen receptor-alpha in pharmacogenetics of estrogen action". Curr. Opin. Lipidol. 14 (2): 145–50. doi:10.1097/00041433-200304000-00005. PMID 12642782. 
  • Tanaka Y, Sasaki M, Kaneuchi M et al. (2004). "Estrogen receptor alpha polymorphisms and renal cell carcinoma--a possible risk". Mol. Cell. Endocrinol. 202 (1–2): 109–16. doi:10.1016/S0303-7207(03)00071-6. PMID 12770739. 
  • Ali S, Coombes RC (2004). "Estrogen receptor alpha in human breast cancer: occurrence and significance". Journal of mammary gland biology and neoplasia 5 (3): 271–81. doi:10.1023/A:1009594727358. PMID 14973389. 
  • Olsson H (2004). "Estrogen receptor content in malignant breast tumors in men--a review". Journal of mammary gland biology and neoplasia 5 (3): 283–7. doi:10.1023/A:1009546811429. PMID 14973390. 
  • Surmacz E, Bartucci M (2005). "Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer". J. Exp. Clin. Cancer Res. 23 (3): 385–94. PMID 15595626. 
  • Evinger AJ, Levin ER (2005). "Requirements for estrogen receptor alpha membrane localization and function". Steroids 70 (5–7): 361–3. doi:10.1016/j.steroids.2005.02.015. PMID 15862818. 
  • Wang CL, Tang XY, Chen WQ et al. (2007). "Association of estrogen receptor alpha gene polymorphisms with bone mineral density in Chinese women: a meta-analysis". Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 18 (3): 295–305. doi:10.1007/s00198-006-0239-2. PMID 17089081. 
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  • Schwabe JW, Neuhaus D, Rhodes D (1991). "Solution structure of the DNA-binding domain of the oestrogen receptor". Nature 348 (6300): 458–61. doi:10.1038/348458a0. PMID 2247153. 
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