Nitrosourea

Nitrosourea
Identifiers
CAS number 13010-20-3 N
PubChem 105035
ChemSpider 94772 YesY
Jmol-3D images Image 1
Image 2
Properties
Molecular formula CH3N3O2
Molar mass 89.05 g mol−1
Exact mass 89.022526355 g mol-1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Nitrosourea is both the name of a molecule, and a class of compounds that include a nitroso (R-NO) group and a urea.

Contents

Examples

Examples include:

Nitrosourea compounds are DNA alkylating agents and are often used in chemotherapy.[1] They are lipophilic and thus can cross the blood-brain barrier, making them useful in the treatment of brain tumors such as glioblastoma multiforme.[2]

Side effects

Some nitrosoureas (e.g. lomustine) have been associated with the development of interstitial lung disease.[3]

References

  1. ^ "Antineop". http://faculty.swosu.edu/scott.long/phcl/antineop.htm. Retrieved 2009-01-24. 
  2. ^ Takimoto CH, Calvo E. "Principles of oncologic pharmacotherapy". in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) Cancer management: a multidisciplinary approach. 11 ed. 2008.
  3. ^ Tucci E, Verdiani P, Di Carlo S, Sforza V (1986). "Lomustine (CCNU)-induced pulmonary fibrosis". Tumori 72 (1): 95–8. PMID 3952821. 

External links


DNA replication
inhibitor Photosensitizers/PDT Other

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Look at other dictionaries:

  • nitrosourea — /nuy troh soh yoo ree euh/, n. Pharm. any of various lipid soluble, synthetic or naturally occurring alkylating agents that can cross the blood brain barrier: used in the treatment of certain brain cancers. [NITROSO + UREA] * * * …   Universalium

  • nitrosourea — noun The nitroso derivative of urea NH CONH N=O, or any of its derivatives, many of which are pharmaceuticals …   Wiktionary

  • nitrosourea — Alkylating agent used in the treatment of many neoplasms; an example is BCNU [N,N′ bis(2 chloroethyl) N n.; carmustine]. * * * ni·tro·so·urea yu̇ rē ə n any of a group of lipid soluble drugs that function as alkylating agents, have the ability to …   Medical dictionary

  • nitrosourea — ni·tro·so·urea …   English syllables

  • nitrosourea — An anticancer drug that can cross the blood brain barrier. Carmustine and lomustine are nitrosoureas …   English dictionary of cancer terms

  • nitrosourea — ˌ noun Etymology: nitros + urea : any of a group of lipid soluble drugs that function as alkylating agents, have the ability to enter the central nervous system, and are effective in the treatment of some brain tumors and meningeal leukemias * *… …   Useful english dictionary

  • N-methyl-N-nitrosourea — N metil N nitrozokarbamidas statusas T sritis chemija formulė CH₃N(NO)CONH₂ atitikmenys: angl. N methyl N nitrosourea rus. N метил N нитрозомочевина …   Chemijos terminų aiškinamasis žodynas

  • sarcosinamide nitrosourea — A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called alkylating agents. Also called sarCNU …   English dictionary of cancer terms

  • ENU — For other uses, see ENU (disambiguation). ENU Systematic name 1 Ethyl 1 nitrosourea …   Wikipedia

  • N-Ethyl-N-nitrosoharnstoff — Strukturformel Allgemeines Name N Ethyl N nitrosoharnstoff Andere …   Deutsch Wikipedia


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