Systematic (IUPAC) name
2-(dimethylamino)ethyl (1-hydroxycyclopentyl)(phenyl)acetate
Clinical data
Pregnancy cat. C
Legal status  ?
Routes Topic
CAS number 512-15-2 YesY
ATC code S01FA04
PubChem CID 2905
DrugBank DB00979
ChemSpider 2802 YesY
KEGG D07759 YesY
Chemical data
Formula C17H25NO3 
Mol. mass 291.385 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Cyclopentolate is a mydriatic and cycloplegic agent commonly used during pediatric eye examinations. Cyclopentolate is also administered as an atropine substitute to reverse muscarinic and CNS effects of indirect cholinomimetic (anti-AChase) administration.

When used in eye drops in pediatric eye examinations, Cyclopentolate 0.5% and 1.0% is used to stop the eye focusing at near distance, enabling the optometrist, ophthalmologist or orthoptist to obtain a more accurate reading of the focusing power of the eyes.

The drops take around 30 minutes to work and around 24 hours to wear off (with patients advised not to drive a vehicle or operate machinery for the first 12 hours). The pupils become wider when Cyclopentolate is administered, making the eyes more sensitive to light. Close objects (and possibly distant objects) will also appear blurred.

Both eyes instilled with cyclopentolate 1%, causing both mydriasis and cycloplegia
Cycloplegia caused by Cyclopentolate 1% instilled into both eyes.

Side effects to Cyclopentolate are rare, but can include effects such as disorientation, incoherent speech or visual disturbances during the 24-hour period that the drug has an effect.