Terminator (genetics)


Terminator (genetics)

In genetics, a terminator, or transcription terminator is a section of genetic sequence that marks the end of gene or operon on genomic DNA for transcription.

In prokaryotes, two classes of transcription terminators are known:

  1. Intrinsic transcription terminators where a hairpin structure forms within the nascent transcript that disrupts the mRNA-DNA-RNA polymerase ternary complex.
  2. Rho-dependent transcription terminators that require Rho factor, an RNA helicase protein complex, to disrupt the nascent mRNA-DNA-RNA polymerase ternary complex.

In eukaryotes, terminators are recognized by protein factors

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