L-selectin


L-selectin

L-selectin, also known as CD62L, is a cell adhesion molecule found on leukocytes. It belongs to the selectin family of proteins, which recognise sialylated carbohydrate groups. It is cleaved by ADAM17.

PBB_Summary
section_title =
summary_text = SELL is a cell surface component that is a member of a family of adhesion/homing receptors which play important roles in leukocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins. [cite web | title = Entrez Gene: SELL selectin L (lymphocyte adhesion molecule 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6402| accessdate = ]

Ligands

*GlyCAM-1, found in the high endothelial venules of the lymph nodes.
*CD34, found on endothelial cells.
*MadCAM-1, found on endothelial cells of gut associated lymphoid tissue.
*PSGL-1, binds with low affinity.

Function

L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via the high endothelial venules. Ligands present on endothelial cells will bind to leukocytes expressing L-selectin, which causes the leukocytes to become localised at that pointcite book | title=Robbins Pathologic Basis of Disease| last=Cotran| coauthors=Kumar, Collins| publisher=W.B Saunders Company| location=Philadelphia| id=0-7216-7335-X] . The receptor is also found on the cell surfaces of "naive" T cells, which have not yet encountered their specific antigen. This surface expression is lost after the cells are activated.

External links

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References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ryan US, Worthington RE |title=Cell-cell contact mechanisms. |journal=Curr. Opin. Immunol. |volume=4 |issue= 1 |pages= 33–7 |year= 1992 |pmid= 1375831 |doi=
*cite journal | author=Nicholson IC |title=CD62L (L-selectin). |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 2 |pages= 144–6 |year= 2003 |pmid= 12144128 |doi=
*cite journal | author=Ivetic A, Ridley AJ |title=The telling tail of L-selectin. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 6 |pages= 1118–21 |year= 2005 |pmid= 15506984 |doi= 10.1042/BST0321118
*cite journal | author=Lasky LA, Singer MS, Dowbenko D, "et al." |title=An endothelial ligand for L-selectin is a novel mucin-like molecule. |journal=Cell |volume=69 |issue= 6 |pages= 927–38 |year= 1992 |pmid= 1376638 |doi=
*cite journal | author=Ord DC, Ernst TJ, Zhou LJ, "et al." |title=Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils. |journal=J. Biol. Chem. |volume=265 |issue= 14 |pages= 7760–7 |year= 1990 |pmid= 1692315 |doi=
*cite journal | author=Bevilacqua M, Butcher E, Furie B, "et al." |title=Selectins: a family of adhesion receptors. |journal=Cell |volume=67 |issue= 2 |pages= 233 |year= 1991 |pmid= 1717161 |doi=
*cite journal | author=Tedder TF, Isaacs CM, Ernst TJ, "et al." |title=Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins. |journal=J. Exp. Med. |volume=170 |issue= 1 |pages= 123–33 |year= 1989 |pmid= 2473156 |doi=
*cite journal | author=Camerini D, James SP, Stamenkovic I, Seed B |title=Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor. |journal=Nature |volume=342 |issue= 6245 |pages= 78–82 |year= 1989 |pmid= 2509939 |doi= 10.1038/342078a0
*cite journal | author=Bowen BR, Nguyen T, Lasky LA |title=Characterization of a human homologue of the murine peripheral lymph node homing receptor. |journal=J. Cell Biol. |volume=109 |issue= 1 |pages= 421–7 |year= 1989 |pmid= 2663882 |doi=
*cite journal | author=Siegelman MH, Weissman IL |title=Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 14 |pages= 5562–6 |year= 1989 |pmid= 2664786 |doi=
*cite journal | author=Bajorath J, Aruffo A |title=A template for generation and comparison of three-dimensional selectin models. |journal=Biochem. Biophys. Res. Commun. |volume=216 |issue= 3 |pages= 1018–23 |year= 1995 |pmid= 7488174 |doi= 10.1006/bbrc.1995.2722
*cite journal | author=Dianzani U, Bragardo M, Buonfiglio D, "et al." |title=Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120. |journal=Eur. J. Immunol. |volume=25 |issue= 5 |pages= 1306–11 |year= 1995 |pmid= 7539755 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Brenner B, Gulbins E, Schlottmann K, "et al." |title=L-selectin activates the Ras pathway via the tyrosine kinase p56lck. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 26 |pages= 15376–81 |year= 1997 |pmid= 8986819 |doi=
*cite journal | author=Zöllner O, Lenter MC, Blanks JE, "et al." |title=L-selectin from human, but not from mouse neutrophils binds directly to E-selectin. |journal=J. Cell Biol. |volume=136 |issue= 3 |pages= 707–16 |year= 1997 |pmid= 9024699 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Prakobphol A, Thomsson KA, Hansson GC, "et al." |title=Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity. |journal=Biochemistry |volume=37 |issue= 14 |pages= 4916–27 |year= 1998 |pmid= 9538010 |doi= 10.1021/bi972612a
*cite journal | author=Sassetti C, Tangemann K, Singer MS, "et al." |title=Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34. |journal=J. Exp. Med. |volume=187 |issue= 12 |pages= 1965–75 |year= 1998 |pmid= 9625756 |doi=
*cite journal | author=Malhotra R, Ward M, Sim RB, Bird MI |title=Identification of human complement Factor H as a ligand for L-selectin. |journal=Biochem. J. |volume=341 ( Pt 1) |issue= |pages= 61–9 |year= 1999 |pmid= 10377245 |doi=

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