Desmoglein


Desmoglein

The desmogleins are a family of cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation of desmosomes that join cells to one another.

Pathology

Desmogleins are targeted in the autoimmune disease pemphigus.[1][2][3]

References

  1. ^ Waschke J, Bruggeman P, Baumgartner W, Zillikens D, Drenckhahn D (November 2005). "Pemphigus foliaceus IgG causes dissociation of desmoglein 1–containing junctions without blocking desmoglein 1 transinteraction". J. Clin. Invest. 115 (11): 3157–65. doi:10.1172/JCI23475. PMC 1242188. PMID 16211092. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1242188. 
  2. ^ Kljuic A, Bazzi H, Sundberg JP, et al. (April 2003). "Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris". Cell 113 (2): 249–60. doi:10.1016/S0092-8674(03)00273-3. PMID 12705872. http://linkinghub.elsevier.com/retrieve/pii/S0092867403002733. 
  3. ^ Müller R, Heber B, Hashimoto T, et al. (May 2009). "Autoantibodies against desmocollins in European patients with pemphigus". Clin. Exp. Dermatol. 34 (8): 898–903. doi:10.1111/j.1365-2230.2009.03241.x. PMID 19456767. 

External links

Calcium-dependent Other see also cell membrane protein disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Desmoglein 1 — Identifiers Symbols DSG1; CDHF4; DG1; DSG; PPKS1; SPPK1 External IDs OM …   Wikipedia

  • Desmoglein 3 — Identifiers Symbols DSG3; CDHF6; DKFZp686P23184; PVA External IDs OMIM …   Wikipedia

  • Desmoglein 2 — Identifiers Symbols DSG2; ARVC10; ARVD10; CDHF5; CMD1BB; HDGC; MGC117034; MGC117036; MGC117037 External IDs …   Wikipedia

  • Desmoglein — Das Desmoglein Protein ist ein integrales Membranprotein und gehört zur Gruppe der Calcium bindenden Cadherine. Man findet es in Epithelien wieder, wo es ein Bestandteil der Desmosomen (Macula adhaerens) ist, einem Interzellulkarkontakt.… …   Deutsch Wikipedia

  • desmoglein — Transmembrane glycoprotein (165 kD) found in desmosomes …   Dictionary of molecular biology

  • desmoglein — des·mog·le·in (dez mogґle in) any of a family of cadherins found in desmosomes; they are the target of autoantibodies in pemphigus foliaceus and pemphigus vulgaris. Cf. desmocollin …   Medical dictionary

  • Dsg — desmoglein …   Medical dictionary

  • Dsg — • desmoglein …   Dictionary of medical acronyms & abbreviations

  • DSG4 — Desmoglein 4 Identifiers Symbols DSG4; CDGF13; CDHF13; LAH External IDs OMIM:&# …   Wikipedia

  • Pemphigus — Classification and external resources ICD 10 L10 ICD …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.